WordNet

be worthy of or have a certain rating; "This bond rates highly"
amount of a charge or payment relative to some basis; "a 10-minute phone call at that rate would cost $5" (同)charge per unit
a magnitude or frequency relative to a time unit; "they traveled at a rate of 55 miles per hour"; "the rate of change was faster than expected"
a quantity or amount or measure considered as a proportion of another quantity or amount or measure; "the literacy rate"; "the retention rate"; "the dropout rate"
assign a rank or rating to; "how would you rank these students?"; "The restaurant is rated highly in the food guide" (同)rank, range, order, grade, place
estimate the value of; "How would you rate his chances to become President?"; "Gold was rated highly among the Romans" (同)value
give (hair) the appearance of being fuller by using a rat
a pad (usually made of hair) worn as part of a womans coiffure
any of various long-tailed rodents similar to but larger than a mouse
catch rats, especially with dogs
desert ones party or group of friends, for example, for ones personal advantage
employ scabs or strike breakers in
standing or position on a scale
any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
a local tax on property (usually used in the plural)

PrepTutorEJDIC

〈C〉『割合』,『率』 / 〈C〉《the~,a~》『速度』(speed),進度 / 〈C〉『値段』,『相場』;料金 / 〈U〉等級(class),(…)等 / 《複数形ぃ》《英》地方税 / (…の金額に)…‘の'『値段を決める』,見積もる《+『名』+『at』+『名』》 / …‘を'『評価する』,みなす / 《米話》…‘に'値する,‘の'価値がある / 『評価される』;みなされる
…‘を'どなりつける
『ネズミ』 / ひきょう者,裏切り者 / ネズミをつかまえる / 《話》(人を)裏切る,密告する《+『on』+『名』〈人〉》
〈C〉〈U〉（品質・技量などによる）格づけ,評価 / 〈C〉（個人・会社の経済的な）信用度 / 〈C〉(トン・馬力による)(船舶・車)の等級 / 〈C〉(テレビ・ラジオの)視聴率
酵素

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1. 心房細動における心拍数のコントロール：薬理療法 control of ventricular rate in atrial fibrillation pharmacologic therapy
2. ノンストレス検査および収縮ストレス検査 nonstress test and contraction stress test
3. 原発性無月経の病因、診断、および治療 etiology diagnosis and treatment of primary amenorrhea
4. 心不全患者における心房細動のマネージメント the management of atrial fibrillation in patients with heart failure
5. 心腎症候群：予後および治療 cardiorenal syndrome prognosis and treatment

Transport vs. metabolism: what determines the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs? Insights from the extended clearance model.

Patilea-Vrana G1, Unadkat JD1.
Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2016 Jul 22. doi: 10.1002/cpt.437. [Epub ahead of print]
The well-stirred hepatic clearance model (WSHM) has been expanded to include drug transporters (i.e. extended clearance model [ECM]). But, the consequences of this expansion in understanding when transporters vs. metabolic enzymes will affect the PK and PD of drugs remains opaque. Identifying the ra
PMID 27448198

Histone Deacetylase 8: Characterization of Physiological Divalent Metal Catalysis.

Nechay MR1, Gallup NM1, Morgenstern A2, Smith QA1, Eberhart ME2, Alexandrova AN1,3.
The journal of physical chemistry. B.J Phys Chem B.2016 Jul 7;120(26):5884-95. doi: 10.1021/acs.jpcb.6b00997. Epub 2016 Mar 30.
Histone deacetylases (HDACs) are responsible for the removal of acetyl groups from histones, resulting in gene silencing. Overexpression of HDACs is associated with cancer, and their inhibitors are of particular interest as chemotherapeutics. However, HDACs remain a target of mechanistic debate. HDA
PMID 26996235

Study of Common Genetic Variant S447X in Lipoprotein Lipase and Its Association with Lipids and Lipoproteins in Type 2 Diabetic Patients.

Momin AA1, Bankar MP2, Bhoite GM3.
Indian journal of clinical biochemistry : IJCB.Indian J Clin Biochem.2016 Jul;31(3):286-93. doi: 10.1007/s12291-015-0531-z. Epub 2015 Oct 13.
Elevated plasma triglyceride and non-esterified fatty acid concentrations may cause insulin resistance and type 2 diabetes mellitus. Lipoprotein lipase (LPL) is a rate-determining enzyme in lipid metabolism. A variant in the LPL gene has been identified which alters the penultimate amino acid Serine
PMID 27382199

Improvement of Poly(3-Hydroxybutyrate)[P(3HB)] Production in Corynebacterium glutamicum by Codon Optimization, Point Mutation and Gene Dosage of P(3HB) Biosynthetic Genes(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Jo Sung-Jin,Matsumoto Ken'ichiro,Leong Chean Ring [他],Ooi Toshihiko,Taguchi Seiichi
Journal of bioscience and bioengineering 104(6), 457-463, 2007-12-25
In our previous study, a system for producing poly(3-hydroxybutyrate) [P(3HB)] was established by introducing a polyhydroxyalkanoate (PHA) biosynthetic gene operon (phaCAB_<Re>) derived from Ral …
NAID 110006533080

Hata Masayuki,Fujii Yasuyuki,Tanaka Yoshikazu [他],Tanaka Yoshikazu,Ishikawa Hidenori,Ishii Miho,Neya Saburo,根矢三郎,Tsuda Minoru,津田穣,ツダミノル,Hoshino Tyuji,星野忠次
Biological & pharmaceutical bulletin 29(11), 2151-2159, 2006-11-01
… The rate-determining process is the tetrahedral intermediate (TI)formation and the activation energy is 24.6 kcal/mol at the DFT level. … Tyr150Oη is stabilized in the deprotonated state in the acyl-enzyme complexand works as a general base. …
NAID 110004840384

Characteristics of a Monoacylglycerol Lipase Isolated from Pseudomonas sp. LP7315 -Hydrolysis and Synthesis of Monoglycerides

Sakiyama Takaharu,Yoshimi Tsuyoshi,Miyake Akira,Umeoka Midori,Tanaka Atsushi,Ozaki Sho,Nakanishi Kazuhiro
Memoirs of the Faculty of Engineering, Okayama University 35(1-2), 137-146, 2001-03-27
… The purified enzyme was homogeneous on an SDS-polyacrylamide gel with a molecular mass of 59 kDa. … Itshydrolytic activity was confirmed to be specific for monoglycerides: the enzyme did not hydrolyze diandtriglycerides. … The synthetic reactionproceeded at a constant rate for approximately 24 h and reached an equilibrium after 48 h of reaction. …
NAID 120002307705