WordNet
- talk volubly
- genre of African-American music of the 1980s and 1990s in which rhyming lyrics are chanted to a musical accompaniment; several forms of rap have emerged (同)rap music, hip-hop
- a gentle blow (同)strike, tap
- voluble conversation
- strike sharply; "rap him on the knuckles" (同)knap
- perform rap music
- an electrical phenomenon whereby an electromotive force (EMF) is generated in a closed circuit by a change in the flow of current (同)inductance
- the act of bringing about something (especially at an early time); "the induction of an anesthetic state"
- done or occurring in a brief period of time; "a rapid rise through the ranks"
- a part of a river where the current is very fast
- characterized by speed; moving with or capable of moving with high speed; "a rapid movement"; "a speedy car"; "a speedy errand boy" (同)speedy
PrepTutorEJDIC
- (…を)『コツン』(『トン』)『とたたくこと』(『音』)《+『on』(『at』)+『名』》 / 《話》(人のしたことに対する)非難,とがめ《+『for』+『名』》 / 《俗》おしゃべり / …‘を'コツン(トン)とたたく / 〈命令など〉‘を'びしゃりと言う《+『out』+『名』,+『名』+『out』》 / (…を)コツン(トン)とたたく《+『at』(on)+『名』》 / 《俗》互いに気持ちよく話す・〔俗〕 非難(する); 叱る; 〔俗〕 告訴[処罰,逮捕](する); 〔俗〕 おしゃべり(する); 〔米俗〕 ラップ(ミュージック); 〔米俗〕 ラップで歌う・「take the rap」で「甘んじて罰を受ける」
- 少しも(…しない)
- 〈C〉《米》募兵 / 〈C〉(聖職・公職などへの)就任,就任式 / 〈U〉〈C〉(…を)引き起こすこと《+『to』+『名』》 / 〈U〉(電気の)誘導 / 〈U〉〈C〉(論理学・数学で)帰納,帰納法
- 『速い』,『すばやい』,敏速な / (坂などが)急な,険しい / 急流,早瀬
UpToDate Contents
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English Journal
- Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma.
- Flesher RP, Herbert C, Kumar RK.Author information *Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.AbstractEndogenous mediators, such as RvE1 (resolvin E1), promote resolution of an inflammatory response and have potential as novel therapeutic agents. In the present study, we investigated the activity of RvE1 in a model of an acute exacerbation of chronic allergic asthma in mice. Animals sensitized to OVA (ovalbumin) received controlled low-level challenge with aerosolized antigen for 4 weeks, followed by a single moderate-level challenge to simulate an allergen-induced exacerbation of asthmatic inflammation. Induction of an exacerbation was associated with rapid recruitment of neutrophils, lymphocytes and eosinophils, together with increased levels of Th2 and pro-inflammatory cytokines. When administered before the final moderate-level challenge, RvE1 had only a modest effect on airway inflammation. To assess its effects when administered after induction of an exacerbation, we first characterized the cellular and molecular events associated with spontaneous resolution of airway inflammation over the following 96 h. Subsequently, we showed that administration of RvE1 at 2 and 8 h after the final challenge accelerated this process significantly. Specifically, RvE1 promoted a decline in the number of inflammatory cells, concentration of cytokines in lavage fluid and expression of mRNA for cytokines by macrophages, confirming its pro-resolution activity. In vitro, RvE1 had no apparent effect on lymphocytes, but suppressed significantly cytokine production by pulmonary macrophages, with evidence of down-regulation of the nuclear translocation of NF-κB (nuclear factor κB) p65 in these cells. The present study provides novel evidence that RvE1 can facilitate resolution of airway inflammation in a clinically relevant model of an acute exacerbation of asthma, possibly via its effects on activated pulmonary macrophages.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jun 1;126(11):805-14. doi: 10.1042/CS20130623.
- Endogenous mediators, such as RvE1 (resolvin E1), promote resolution of an inflammatory response and have potential as novel therapeutic agents. In the present study, we investigated the activity of RvE1 in a model of an acute exacerbation of chronic allergic asthma in mice. Animals sensitized to O
- PMID 24344649
- Induction Therapy with Combination TNF Inhibitor and Methotrexate in Early Rheumatoid Arthritis.
- Hwang YG1, Moreland LW.Author information 1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, S703 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA, USA, hwangyg@upmc.edu.AbstractWith the introduction of more objective disease activity measures and the development of biological therapies, there were dramatic changes in the treatment of rheumatoid arthritis (RA). The combination therapy with tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) has unprecedentedly improved prognosis and outcomes, and very low disease activity or remission has been achievable goal in RA. Although the concept of remission induction and maintenance was first discussed in longstanding RA patients, several clinical trials have demonstrated that there is a therapeutic window of opportunity, and early effective control of inflammation in early RA could lead to less joint damage and better long-term outcomes. Emerging evidence suggests that early combination therapy with TNF inhibitor and MTX leads to rapid clinical remission and thereby improved quality of life. Furthermore, remission status may be sustained in some patients even if a TNF inhibitor is discontinued after sustained remission in early RA patients. While there are many potential benefits of early remission induction therapy with the combination of a TNF inhibitor and MTX, the best therapeutic regimen and strategy for remission induction and maintenance in early RA remain controversial. There are no data to decide a priori when and in whom TNF blocker drugs are indicated in early disease-modifying anti-rheumatic drug (DMARD)-naïve RA.
- Current rheumatology reports.Curr Rheumatol Rep.2014 May;16(5):417. doi: 10.1007/s11926-014-0417-8.
- With the introduction of more objective disease activity measures and the development of biological therapies, there were dramatic changes in the treatment of rheumatoid arthritis (RA). The combination therapy with tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) has unprecedentedly impr
- PMID 24619653
- Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK.
- Elbourkadi N1, Austad SN, Miller RA.Author information 1Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.AbstractFibroblasts from long-lived mutant mice show diminished phosphorylation of the stress-activated protein kinases ERK1/2 after exposure to peroxide, cadmium, or paraquat. We have now evaluated the kinetics of ERK phosphorylation in fibroblasts from long-lived and short-lived species of mammals and birds in response to stress by cadmium or hydrogen peroxide. Fibroblasts from the shorter-lived species of rodents and birds showed rapid induction of ERK phosphorylation, with a decline to basal level within 60 min. In contrast, cells from longer-lived species showed slower and more prolonged activation of ERK phosphorylation. These results suggest that fibroblasts from long-lived species may be less susceptible to the early phases of damage from cadmium or peroxide and suggest that altered kinetics of ERK activity may contribute to their stress resistance properties.
- Aging cell.Aging Cell.2014 Apr;13(2):283-91. doi: 10.1111/acel.12172. Epub 2013 Nov 13.
- Fibroblasts from long-lived mutant mice show diminished phosphorylation of the stress-activated protein kinases ERK1/2 after exposure to peroxide, cadmium, or paraquat. We have now evaluated the kinetics of ERK phosphorylation in fibroblasts from long-lived and short-lived species of mammals and bir
- PMID 24219321
Japanese Journal
- 誤嚥予防の全身麻酔導入・維持 (特集 周術期誤嚥性肺炎)
- Quantification of the Amorphous Content of Ursodeoxycholic Acid by Pulsed NMR
- Lipopolysaccharide Delays Closure of the Rat Ductus Arteriosus by Induction of Inducible Nitric Oxide Synthase But Not Prostaglandin E<sub>2</sub>
Related Links
- Online Induction Software for Employee and Contractor Inductions. Fully editable and simple to use Online Induction Software.
★リンクテーブル★
[★]
- 英
- rapid induction
- 同
- クラッシュ導入 crash induction
[★]
- 引き入れること、誘導、導入。(電)誘導。感応、誘発。(発)誘導。(生化)誘導。(医)陣痛/分娩誘発
- 関
- challenge、derivation、elicit、elicitation、guidance、induce、inductive、introduce、introduction、precipitate、provocation、provoke、spark
[★]
- 関
- expeditious、fast、prompt、promptly、quick、quickly、rapidly、swift
[★]