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English Journal

Cerci JJ1, Tabacchi E2, Bogoni M3.
PET clinics.PET Clin.2016 Jan;11(1):57-64. doi: 10.1016/j.cpet.2015.08.001. Epub 2015 Sep 28.
PET/computed tomography (CT) combines the anatomic information from CT with PET metabolic characterization. 18F-fluorodeoxyglucose (FDG) PET is helpful to differentiate malignant lesions from benign ones, that usually show lower or no uptake. However, active inflammation or infectious disease might
PMID 26590444

New synthesis of phenyl-isothiocyanate C-functionalised cyclams. Bioconjugation and (64)Cu phenotypic PET imaging studies of multiple myeloma with the te2a derivative.

Halime Z1, Frindel M2, Camus N1, Orain PY1, Lacombe M3, Chérel M3, Gestin JF3, Faivre-Chauvet A3, Tripier R1.
Organic & biomolecular chemistry.Org Biomol Chem.2015 Dec 14;13(46):11302-14. doi: 10.1039/c5ob01618e.
Azamacrocyclic bifunctional chelating agents (BCAs) are essential for the development of radiopharmaceuticals in nuclear medicine and we wish to prove that their bioconjugation by a function present on a carbon atom of the macrocyclic skeleton is a solution of choice to maintain their in vivo inertn
PMID 26419637

An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization.

Lee SJ1, Fowler JS2, Alexoff D2, Schueller M2, Kim D2, Nauth A3, Weber C3, Kim SW2, Hooker JM4, Ma L5, Qu W2.
Organic & biomolecular chemistry.Org Biomol Chem.2015 Dec 14;13(46):11235-43. doi: 10.1039/c5ob01654a.
A rapid method for the synthesis of carbon-11 radiolabeled indole was developed using a sub-nanomolar quantity of no-carrier-added [(11)C]cyanide as radio-precursor. Based upon a reported synthesis of 2-(2-nitrophenyl)acetonitrile (), a highly reactive substrate 2-nitrobenzyl bromide () was evaluate
PMID 26411301

In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

Sano Kohei,Okada Mayumi,Hisada Hayato,Shimokawa Kenta,Saji Hideo,Maeda Minoru,Mukai Takahiro
Biological and Pharmaceutical Bulletin 36(4), 602-608, 2013
… 67Ga-labeling of DOTA-MN2 with 67GaCl3 was achieved with high radiochemical yield (>85%) by 1-min of microwave irradiation (50 W). …
NAID 130003361390

Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3- trifluoromethyl-benzamide ([11 C]N-methyl- SSR504734) as a PET radioligand for glycine transporter 1

Fuchigami Takeshi,Takano Akihiro,Gulyás Balázs,Jia Zhisheng,Finnema Sjoerd J,Andersson Jan D,Nakao Ryuji,Magata Yasuhiro,Haratake Mamoru,Nakayama Morio,Halldin Christer
EJNMMI Research 2(1), 37, 2012-07-09
… Results [11 C]N-methyl-SSR504734 was successfully synthesized in moderate radiochemical yield and high specific radioactivity. …
NAID 120005231371