- 関
- quinapril
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/29 16:59:18」(JST)
[Wiki en表示]
Quinapril
|
| Systematic (IUPAC) name |
|
(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
|
| Clinical data |
| Trade names |
Accupril |
| AHFS/Drugs.com |
Monograph |
| MedlinePlus |
a692026 |
Pregnancy
category |
|
Routes of
administration |
Oral |
| Legal status |
| Legal status |
|
| Pharmacokinetic data |
| Protein binding |
97% |
| Biological half-life |
2 hours |
| Identifiers |
| CAS Number |
85441-61-8 Y |
| ATC code |
C09AA06 (WHO) |
| PubChem |
CID 54892 |
| IUPHAR/BPS |
6350 |
| DrugBank |
DB00881 Y |
| ChemSpider |
49565 Y |
| UNII |
RJ84Y44811 Y |
| KEGG |
D03752 Y |
| ChEBI |
CHEBI:8713 Y |
| ChEMBL |
CHEMBL1592 Y |
| Chemical data |
| Formula |
C25H30N2O5 |
| Molar mass |
438.516 g/mol |
SMILES
-
O=C(OCC)[C@@H](N[C@H](C(=O)N2[C@H](C(=O)O)Cc1c(cccc1)C2)C)CCc3ccccc3
|
InChI
-
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1 Y
-
Key:JSDRRTOADPPCHY-HSQYWUDLSA-N Y
|
| Physical data |
| Melting point |
120 to 130 °C (248 to 266 °F) |
| (verify) |
Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. A prodrug, it is converted to its active metabolite, quinaprilat, in the liver.
Contents
- 1 Mechanism of action
- 2 Indications
- 3 Contraindications
- 4 Side effects
- 5 External links
Mechanism of action
Main article: ACE inhibitor
See also: Angiotensin and renin-angiotensin system
Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.
Indications
Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.
Contraindications
- Pregnancy
- Impaired renal and liver function
- Patients with a history of angioedema related to previous treatment with an ACE inhibitor
- Hypersensitivity to quinapril
Side effects
Side effects of quinapril include dizziness, cough, vomiting, upset stomach, angioedema, and fatigue.
External links
- Quinapril FAQ
- Accupril Site
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Antihypertensives: agents acting on the renin–angiotensin system (C09)
|
|
ACE inhibitors
("-pril") |
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril
- Dicarboxylate-containing: Enalapril#
- Benazepril
- Cilazapril
- Delapril
- Imidapril
- Lisinopril (+HCT)
- Moexipril
- Perindopril (+indapamide)
- Quinapril (+HCT)
- Ramipril
- Spirapril
- Temocapril
- Trandolapril
- Phosphonate-containing: Fosinopril (+HCT)
- Other/ungrouped: Alacepril
|
|
AIIRAs
("-sartan") |
- Azilsartan
- Candesartan
- Eprosartan
- Fimasartan
- Irbesartan
- Losartan (+HCT)
- Olmesartan (+amlodipine)
- Tasosartan§
- Telmisartan (+HCT)
- Valsartan (+HCT, +amlodipine, +sacubitril)
|
|
Renin inhibitors
("-kiren") |
- Aliskiren (+amlodipine, +amlodipine and HCT)
- Remikiren§
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
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English Journal
- In vitro study on binding interaction of quinapril with bovine serum albumin (BSA) using multi-spectroscopic and molecular docking methods.
- Shi JH1,2, Pan DQ1, Jiang M1, Liu TT1, Wang Q1.
- Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2017 Aug;35(10):2211-2223. doi: 10.1080/07391102.2016.1213663. Epub 2016 Aug 7.
- PMID 27418394
- The effect of antihypertensive treatment on arterial stiffness and serum concentration of selected matrix metalloproteinases.
- Rajzer M1, Wojciechowska W1, Kameczura T2, Olszanecka A1, Fedak D3, Terlecki M1, Kawecka-Jaszcz K1, Czarnecka D1.
- Archives of medical science : AMS.Arch Med Sci.2017 Jun;13(4):760-770. doi: 10.5114/aoms.2016.58825. Epub 2016 Mar 23.
- PMID 28721143
- Rapid analysis of drug dissolution by paper spray ionization mass spectrometry.
- Liu Y1, Liu N2, Zhou YN2, Lin L2, He L3.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2017 Mar 20;136:106-110. doi: 10.1016/j.jpba.2016.12.025. Epub 2016 Dec 23.
- PMID 28068517
Japanese Journal
- 高齢高血圧患者におけるACE阻害薬塩酸キナプリル反復投与時の血中薬物動態と降圧効果および各種ホルモン系に及ぼす影響
- PRECLINICAL TOXICOLOGY STUDIES WITH THE ANGIOTENSIN-CONVERTING ENZYME INHIBITOR QUINAPRIL HYDROCHLORIDE (ACCUPRIL)
- Quinapril hydrochloride のラットにおける周産期および授乳期投与試験
Related Links
- Learn about the prescription medication Accupril (Quinapril Hydrochloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. ... What are the possible side effects of quinapril (Accupril)? Get ...
- ※この商品に関係するニュース記事へのリンクがページ最下部にあります。 「有効成分」 塩酸キナプリル(Quinapril Hydrochloride) 「同一成分含有商品」 アキュプリル （塩酸キナプリル） 10mg (30錠) 980 円 Accupril (Quinapril ...
★リンクテーブル★
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- 英
- quinapril
- 化
- 塩酸キナプリル quinapril hydrochloride
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- コナン Conan、ナプリシン
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キナプリル
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- quinapril hydrochloride
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塩酸塩、ハイドロクロライド