WordNet
- any of the enzymes that catalyze biological oxidation
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/02/26 17:26:19」(JST)
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pyruvate oxidase |
Identifiers |
EC number |
1.2.3.3 |
CAS number |
9001-96-1 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
In enzymology, a pyruvate oxidase (EC 1.2.3.3) is an enzyme that catalyzes the chemical reaction
- pyruvate + phosphate + O2 acetyl phosphate + CO2 + H2O2
The 3 substrates of this enzyme are pyruvate, phosphate, and O2, whereas its 3 products are acetyl phosphate, CO2, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyruvate:oxygen 2-oxidoreductase (phosphorylating). Other names in common use include pyruvic oxidase, and phosphate-dependent pyruvate oxidase. This enzyme participates in pyruvate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1POW, 1POX, 1V5E, 1V5F, 1V5G, 1Y9D, 2DJI, 2EZ4, 2EZ8, 2EZ9, 2EZT, and 2EZU.
References
- Williams FR, Hager LP (1966). "Crystalline flavin pyruvate oxidase from Escherichia coli. I Isolation and properties of the flavoprotein". Arch. Biochem. Biophys. 116 (1): 168–76. doi:10.1016/0003-9861(66)90025-7. PMID 5336022.
- Tittmann K, Wille G, Golbik R, Weidner A, Ghisla S, Hubner G (2005). "Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair". Biochemistry. 44 (40): 13291–303. doi:10.1021/bi051058z. PMID 16201755.
UpToDate Contents
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English Journal
- The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease.
- Zuo L, Motherwell MS.SourceMolecular Physiology and Biophysics Laboratory, Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA; Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, Biophysics Graduate Program, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: zuo.4@osu.edu.
- Gene.Gene.2013 Dec 10;532(1):18-23. doi: 10.1016/j.gene.2013.07.085. Epub 2013 Aug 15.
- The exact pathogenesis of Parkinson's disease (PD) is still unknown and proper mechanisms that correspond to the disease remain unidentified. It is understood that PD is age-related; as age increases, the chance of onset responds accordingly. Although there are no current means of curing PD, the und
- PMID 23954870
- Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α.
- Ringholm S, Olesen J, Pedersen JT, Brandt CT, Halling JF, Hellsten Y, Prats C, Pilegaard H.SourceCentre of Inflammation and Metabolism, August Krogh Centre, Department of Biology, August Krogh Building, University of Copenhagen, Denmark.
- Experimental gerontology.Exp Gerontol.2013 Nov;48(11):1311-8. doi: 10.1016/j.exger.2013.08.012. Epub 2013 Aug 29.
- BACKGROUND: The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise tr
- PMID 23994519
- Calotropis gigantiea (L.) R. Br (Apocynaceae): A phytochemical and pharmacological review.
- Kadiyala M, Ponnusankar S, Elango K.SourceDepartment of Pharmacology, JSS College of Pharmacy, Udhagamandalam 643001, The Nilgiris, Tamil Nadu, India. Electronic address: madhurikadiyala3@gmail.com.
- Journal of ethnopharmacology.J Ethnopharmacol.2013 Oct 28;150(1):32-50. doi: 10.1016/j.jep.2013.08.045. Epub 2013 Sep 6.
- ETHNOPHARMACOLOGICAL RELEVANCE: Calotropis gigantiea (L.) R. Br (Apocynaceae) commonly called as "crown flower" or "giant milk weed" is a well-known weed to many cultures for treating various disorders related to central nervous system, skin diseases, digestive system, respiratory system, reproducti
- PMID 24012528
Japanese Journal
- Differentially expressed proteins in fluconazole-susceptible and fluconazole-resistant isolates of Candida glabrata
- ビタミンB_6が担うD-セリンの代謝酵素 : セリンラセマーゼとD-セリンデヒドラターゼ(<特集>ビタミンB研究委員会平成25年度シンポジウム「ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究-ビタミン研究が切り拓く疾患生命科学のフロンティア」)
Related Links
- 72 (Diagnostic Reagent Grade) ASAHI KASEI ENZYMES T-45 PYRUVATE OXIDASE [POPG] from Aerococcus viridans (Pyruvate: oxygen oxidoreductase, phosphorylating, EC 1.2.3.3) ...
- PYO-311 Table 2. Effect of Various Chemicals on Pyruvate oxidase [The enzyme dissolved in 50mM K-phosphate, pH 6.0 (10U/ml) was incubated with each chemical at 25 for 1hr] Table 1. Substrate Specificity of Pyruvate oxidase
Related Pictures
★リンクテーブル★
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- 英
- pyruvate oxidase
- 関
- ピルビン酸オキシダーゼ
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- 英
- pyruvate oxidase
- 関
- ピルビン酸酸化酵素
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ピルビン酸 pyruvic acid