pyruvate dehydrogenase

出典: meddic

ピルビン酸デヒドロゲナーゼ

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/24 17:25:55」(JST)

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英文文献

  • Functional analysis of differentially expressed proteins in Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruits during ripening.
  • Chen YY1, Zhang ZH2, Zhong CY3, Song XM3, Lin QH2, Huang CM3, Huang RH3, Chen W4.
  • Food chemistry.Food Chem.2016 Jan 1;190:763-70. doi: 10.1016/j.foodchem.2015.06.023. Epub 2015 Jun 10.
  • This study developed a proteome reference map of Myrica rubra fruits at the green, pink and red stages during ripening using two-dimensional gel electrophoresis (2-DE). Forty-six differentially expressed proteins were detected in the gel, of which 43 were successfully identified by matrix-assisted l
  • PMID 26213036
  • Drug resistance in Giardia duodenalis.
  • Ansell BR1, McConville MJ2, Ma'ayeh SY3, Dagley MJ2, Gasser RB4, Svärd SG3, Jex AR4.
  • Biotechnology advances.Biotechnol Adv.2015 Nov 1;33(6 Pt 1):888-901. doi: 10.1016/j.biotechadv.2015.04.009. Epub 2015 Apr 25.
  • Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a major contributor to diarrheal and post-infectious chronic gastrointestinal disease world-wide. Treatment of G. duodenalis infection currently relies on a small number of drug classes. Nitroheterocyclics, in p
  • PMID 25922317
  • The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
  • Choe M1,2, Brusgard JL3, Chumsri S4, Bhandary L4, Zhao XF5,6, Lu S5, Goloubeva OG7, Polster BM8, Fiskum GM8, Girnun GD1,9, Kim MS5, Passaniti A1,3,5,10.
  • Journal of cellular biochemistry.J Cell Biochem.2015 Oct;116(10):2210-26. doi: 10.1002/jcb.25171.
  • Activation of genes promoting aerobic glycolysis and suppression of mitochondrial oxidative phosphorylation is one of the hallmarks of cancer. The RUNX2 transcription factor mediates breast cancer (BC) metastasis to bone and is regulated by glucose availability. But, the mechanisms by which it regul
  • PMID 25808624

和文文献

  • 運動前のグリコーゲン減少程度が運動時の代謝応答に与える影響
  • 塩瀬 圭佑,飛奈 卓郎,桧垣 靖樹 [他]
  • 体力科学 = The Japanese journal of physical fitness and sports medicine 63(4), 401-408, 2014-08
  • NAID 40020184713
  • Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis
  • Harada Kenichi,Kakuda Yuko,Sato Yasunori,Ikeda Hiroko,Shimoda Shinji,Yamamoto Yasuhiko,Inoue Hiroshi,Ohta Hajime,Kasashima Satomi,Kawashima Atsuhiro,Nakanuma Yasuni
  • Journal of Clinical Pathology 67(5), 396-402, 2014-05
  • … Aim: Primary biliary cirrhosis (PBC) is characterised by antimitochondrial antibody against the pyruvate dehydrogenase complex (PDC) and chronic nonsuppurative destructive cholangitis (CNSDC). … Pyruvate oxidation to acetyl-CoA by PDC is a key step in the glycolytic system. …
  • NAID 120005469783
  • Bacterial pyruvate production from alginate, a promising carbon source from marine brown macroalgae.
  • Kawai Shigeyuki,Ohashi Kazuto,Yoshida Shiori [他],Fujii Mari,Mikami Shinichi,Sato Nobuyuki,Murata Kousaku
  • Journal of bioscience and bioengineering 117(3), 269-274, 2014-03
  • … strain A1, produces pyruvate from alginate and secretes it into the medium. … High aeration and deletion of the gene for d-lactate dehydrogenase are critical for the production of high concentrations of pyruvate. …
  • NAID 120005385866

関連リンク

Title Pyruvate Dehydrogenase Author Joyce Diwan Last modified by diwanj Created Date 6/7/1999 1:47:47 AM Document presentation format On-screen Show Company Northstar Drive Other titles Times New Roman Wingdings Symbol ...
PDH Application guide View our optimal range to measure all aspects of the pyruvate dehydrogenase complex (PDH). PDH deficiencies, diabetes, starvation, sepsis, and possibly Alzheimer's disease have been linked to altered PDH ...

関連画像

Pyruvate dehydrogenasePyruvate dehydrogenasePyruvate dehydrogenasePyruvate Dehydrogenase Complex Deficiency Pyruvate Dehydrogenase Complexthat compose the pyruvate dehydrogenase


★リンクテーブル★
リンク元解糖系」「ピルビン酸デヒドロゲナーゼ」「代謝系
拡張検索pyruvate dehydrogenase complex deficiency disease」「pyruvate dehydrogenase complex deficiency」「pyruvate dehydrogenase phosphatase」「pyruvate dehydrogenase deficiency
関連記事dehydrogenase」「dehydrogenases」「pyruvate

解糖系」

  [★]

glycolytic pathway
エムデン-マイヤーホフ経路 Embden-Meyerhof pathway
解糖TCA回路
  • CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2OH)H-O- グルコース (OHが↓↓↑↓↑)
  • CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- グルコース-6-リン酸 (OHが↓↓↑↓↑)
  • C(CH2OH)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-6-リン酸
  • C(CH2O-PO3)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-1,6-リン酸
glucose
↓-hexokinase/glucokinase(liver)
glucose 6-phosphate
↓-phosphohexose isomerase
fructose 6-phosphate
↓-phosphofructokinase
fructose 1,6-bisphosphate
↓-aldolase
glyceraldehyde 3-phosphate
↓-glyceraldehyde-3-phosphate dehydrogenase
1,3-bisphosphoglycerate
↓-phosphoglycerate kinase →ATP
3-phosphoglycerate
↓-phosphoglyceate mutase
2-phosphoglycerate
↓-enolase
phosphoenolpyruvate
↓-pyruvate kinase → ATP
pyruvate
 -(pyruvate dehydrogenase)→acetyl-CoA
 -(pyruvate carboxylase)→oxaloacetate-(NADH+H+)→malate


解糖系の酵素 (first aid step1 2006 p.87, FASTEP1_87_酵素一覧.xls)

1 galactokinase キナーゼ  
2 galactose-1-phosphate uridyltransferase 転移酵素  
3 hexokinase/glucokinase キナーゼ  
4 glucose-6-phosphatase ホスファターゼ  
5 glucose-6-phosphate dehydrogenase 脱水素酵素  
6 transketolase    
7 phosphofructokinase キナーゼ  
8 fructose-1,6-bisphosphatase ホスファターゼ  
9 fructokinase キナーゼ フルクトキナーゼ
10 aldolase B   アルドラーゼ
11 pyruvate kinase キナーゼ ピルビン酸キナーゼ
12 pyruvate dehydrogenase 脱水素酵素 ピルビン酸デヒドロゲナーゼ
13 HMG-CoA reductase 還元酵素 HMG-CoA還元酵素
14 pyruvate carboxylase カルボキシラーゼ ピルビン酸カルボキシラーゼ
15 PEP carboxykinase キナーゼ PEPカルボキシキナーゼ
16 citrate synthase 合成酵素 クエン酸合成酵素
17 α-ketoglutarate dehydrogenase 脱水素酵素 α-ケトグルタミン酸脱水素酵素
18 ornithine transcarbamylase 転移酵素 オルニチンカルバモイルトランスフェラーゼ




ピルビン酸デヒドロゲナーゼ」

  [★]

pyruvate dehydrogenase
ピルビン酸脱水素酵素ピルビン酸ピルビン酸デヒドロゲナーゼ複合体


概要

  • ピルビン酸からアセチルCoAを生成し、クエン酸回路に投入するための酵素
  • 逆反応を触媒する酵素はない

反応

ピルビン酸+NAD++SH-CoA → アセチルCoA+NADH+CO2 

補酵素

臨床関連

不足

アルコール中毒によるビタミンB1不足によっても生じる



代謝系」

  [★]

metabolic pathway
代謝経路
  • 解糖系
  • TCA回路
  • 電子伝達系
  • 尿酸回路
  • 糖新生経路


pyruvate dehydrogenase complex deficiency disease」

  [★]

ピルビン酸脱水素酵素複合体欠損症ピルビン酸デヒドロゲナーゼ複合体欠損症


pyruvate dehydrogenase complex deficiency」

  [★] ピルビン酸脱水素酵素複合体欠損症

PDHC

pyruvate dehydrogenase phosphatase」

  [★]


pyruvate dehydrogenase deficiency」

  [★] ピルビン酸脱水素酵素欠損症


dehydrogenase」

  [★] 脱水素酵素 デヒドロゲナーゼ


dehydrogenases」

  [★] 脱水素酵素 デヒドロゲナーゼ


pyruvate」

  [★] ピルビン酸 pyruvic acid




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