WordNet

produced by or producing fever (同)pyrogenous, pyrogenetic
(of a chemical reaction or compound) occurring or formed with the liberation of heat (同)exothermal, heat-releasing
causing fever

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1. 連鎖球菌性毒素性ショック症候群の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of streptococcal toxic shock syndrome

Intralaboratory validation of kinetic chromogenic Limulus amebocyte lysate assay for bacterial endotoxin determination in anti-bothropic serum.

Fingola FF, Albertino SR, Abrantes Sde M, Zamith HP.SourceDepartment of Pharmacology and Toxicology, National Institute for Quality Control in Health, Oswaldo Cruz Foundation, Avenida Brasil 4365, 21040-900 Rio de Janeiro, Brazil. fernando.fingola@incqs.fiocruz.br
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Nov;85:93-8. doi: 10.1016/j.jpba.2013.06.034. Epub 2013 Jul 9.
Over the years, substituting in vitro biological methods for in vivo tests has posed an ever increasing challenge for researchers, including those who study the applications for snake antivenom. In the quality control of antivenons, the only official test recommended by pharmacopoeias for detecting
PMID 23912057

The isolation and characterization of lipopolysaccharides from Microcystis aeruginosa, a prominent toxic water bloom forming cyanobacteria.

Bláhová L, Adamovský O, Kubala L, Svihálková Šindlerová L, Zounková R, Bláha L.SourceMasaryk University, Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Kamenice 753/5, Building A29, CZ62500 Brno, Czech Republic.
Toxicon : official journal of the International Society on Toxinology.Toxicon.2013 Oct 16. pii: S0041-0101(13)00397-8. doi: 10.1016/j.toxicon.2013.10.011. [Epub ahead of print]
Massive toxic blooms of cyanobacteria represent a major threat to water supplies worldwide, yet serious gaps exist in understanding their complex toxic effects, including the role of lipopolysaccharides (LPS). The present comparative study focused on the levels and biological activities of LPS isola
PMID 24140921

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test.

Hasiwa N, Daneshian M, Bruegger P, Fennrich S, Hochadel A, Hoffmann S, Rivera-Mariani FE, Rockel C, Schindler S, Spreitzer I, Stoppelkamp S, Vysyaraju K, Hartung T.SourceCAAT-Europe, University of Konstanz, Konstanz, Germany.
ALTEX.ALTEX.2013;30(2):169-208.
Threats of pyrogenicity were discovered more than a century ago. Measures to determine the safety of parenterals and, more recently, medical devices and cell therapies for human use have been in place for 70 years. Currently, there are three testing possibilities available: the Rabbit Pyrogen Test,
PMID 23665806

Platonin, a Cyanine Photosensitizing Dye, Inhibits Pyrogen Release and Results in Antipyresis

LEE Jie-Jen,HUANG Wu-Tein,SHAO Dong-Zi,LIAO Jyh-Fei,LIN Mao-Tsun
Journal of pharmacological sciences 93(3), 376-380, 2003-11-01
… When incubating the platonin with the LPS-human PBMC, both the levels of IL-1β, IL-6, or TNF-α in supernatant fluids and the pyrogenicity of supernatant fluids were significantly suppressed. …
NAID 130000073931

浅井泰行
膜 25(2), 67-72, 2000-03-01
… E5531 suppressed the pyrogenicity of ETX in rabbits.<BR>In addition, in order to evaluate the effects of E5531 on the cell surface membrane, we used dipalmitoylphosphatidylcholine (DPPC) as a model membrane. …
NAID 10007827636

The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli

ASAI Yasuyuki,NOZU Yukio,IKEUCHI Takayuki,NARAZAKI Ryuichi,IWAMOTO Kiyoshi,WATANABE Sumio
Biological & pharmaceutical bulletin 22(4), 432-434, 1999-04-15
… The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. … E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX. …
NAID 110003639685