目次
WordNet
- a heterocyclic organic compound with a penetrating odor
- any of several basic compounds derived from pyrimidine
- a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base
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- 1. 先天性代謝異常：分類 inborn errors of metabolism classification
- 2. 痛風再発の予防 prevention of recurrent gout
- 3. 遺伝性疾患の基本原則 basic principles of genetic disease
- 4. 前立腺癌の危険因子 risk factors for prostate cancer
- 5. 遺伝的変異の概要 overview of genetic variation
English Journal
- Ezrin mRNA target site selection for DNAzymes using secondary structure and hybridization thermodynamics.
- Wang Y, Shen J, Shang X, Wang J, Li J, Yin J, Zou C.SourceDepartment of Orthopaedic Surgery, Musculoskeletal Tumor Center, The First Affiliated Hospital of Sun Yat-Sen University, No.58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, China.
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2011 Aug;32(4):809-17. Epub 2011 May 11.
- Ezrin, a membrane organizer and linker between plasma membrane and cytoskeleton, is well documented to play an important role in the metastatic capacity of cancer cells especially for osteosarcoma cells. It has provided an ideal target for cancer gene therapy. RNA-cleaving 10-23 DNAzymes, consisting
- PMID 21559778
- Escherichia coli Fpg Glycosylase Is Nonrendundant and Required for the Rapid Global Repair of Oxidized Purine and Pyrimidine Damage In Vivo.
- Schalow BJ, Courcelle CT, Courcelle J.AbstractEndonuclease (Endo) III and formamidopyrimidine-N-glycosylase (Fpg) are two of the predominant DNA glycosylases in Escherichia coli that remove oxidative base damage. In cell extracts and purified form, Endo III is generally more active toward oxidized pyrimidines, while Fpg is more active towards oxidized purines. However, the substrate specificities of these enzymes partially overlap in vitro. Less is known about the relative contribution of these enzymes in restoring the genomic template following oxidative damage. In this study, we examined how efficiently Endo III and Fpg repair their oxidative substrates in vivo following treatment with hydrogen peroxide. We found that Fpg was nonredundant and required to rapidly remove its substrate lesions on the chromosome. In addition, Fpg also repaired a significant portion of the lesions recognized by Endo III, suggesting that it plays a prominent role in the global repair of both purine damage and pyrimidine damage in vivo. By comparison, Endo III did not affect the repair rate of Fpg substrates and was only responsible for repairing a subset of its own substrate lesions in vivo. The absence of Endo VIII or nucleotide excision repair did not significantly affect the global repair of either Fpg or Endo III substrates in vivo. Surprisingly, replication recovered after oxidative DNA damage in all mutants examined, even when lesions persisted in the DNA, suggesting the presence of an efficient mechanism to process or overcome oxidative damage encountered during replication.
- Journal of molecular biology.J Mol Biol.2011 Jul 8;410(2):183-93. Epub 2011 May 13.
- Endonuclease (Endo) III and formamidopyrimidine-N-glycosylase (Fpg) are two of the predominant DNA glycosylases in Escherichia coli that remove oxidative base damage. In cell extracts and purified form, Endo III is generally more active toward oxidized pyrimidines, while Fpg is more active towards o
- PMID 21601577
Japanese Journal
- Luminescence-based colorimetric discrimination of single-nucleotide transversions by the combined use of the derivatives of DOTA-conjugated naphthyridine and its terbium complex
- Atsumi Hiroshi,Yoshimoto Keitaro,Saito Shingo,Ohkuma Moriya,Maeda Mizuo,Nagasaki Yukio,吉本 敬太郎,長崎 幸夫
- Tetrahedron letters 50(19), 2177-2180, 2009-05
- … The blue emission of ND-DOTA was selectively quenched by adding abasic site-containing DNA duplexes that have pyrimidine bases opposite to the abasic site. … Thus, a mixed solution of ND-DOTA and ND-DOTA-Tb enabled the luminescence-based colorimetric discrimination of single-nucleotide transversions with the naked eye at a single excitation wavelength. …
- NAID 120001300353
- Characterization of Nucleobase Transport by Mouse Sertoli Cell Line TM4(Biopharmacy)
- KATO Ryo,MAEDA Tomoji,AKAIKE Toshihiro,TAMAI Ikumi
- Biological & pharmaceutical bulletin 32(3), 450-455, 2009-03-01
- … In the spermatogenesis, many nucleosides and nucleobases are needed for the salvage nucleotide biosynthesis. … Here, we examined the uptakes of purine ([^3H]guanine) and pyrimidine ([^3H]uracil) nucleobases using TM4 cells. … Guanine uptake was inhibited by other purine nucleobases, but not by pyrimidine nucleobases. … Only pyrimidine nucleobases reduced uracil uptake. …
- NAID 110007122709
Related Links
- Pyrimidine nucleotide synthesis starts with the formation of carbamoyl phosphate from glutamine and CO2. The cyclisation reaction between carbamoyl phosphate reacts with aspartate, ...
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