WordNet
- of or related to the anus; "anal thermometer"
- a stage in psychosexual development when the childs interest is concentrated on the anal region; fixation at this stage is said to result in orderliness, meanness, stubbornness, compulsiveness, etc. (同)anal retentive
- a heterocyclic organic compound with a penetrating odor
- any of several basic compounds derived from pyrimidine
PrepTutorEJDIC
- 肛門(こうもん)(anus)の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/21 16:00:23」(JST)
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Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
Examples[edit]
Examples include:
- 5-fluorouracil (5FU) which inhibits thymidylate synthase.
- Floxuridine (FUDR)
- Cytosine arabinoside (Cytarabine)
- 6-azauracil (6-AU)
DNA virus antivirals (primarily J05, also S01AD and D06BB)
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Baltimore I |
Herpesvirus
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DNA-synthesis
inhibitor
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TK activated
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Purine analogue
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- guanine (Aciclovir#/Valacyclovir
- Ganciclovir/Valganciclovir
- Penciclovir/Famciclovir)
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Pyrimidine analogue
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- uridine (Idoxuridine
- Trifluridine
- Edoxudine)
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Not TK activated
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Other
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- Docosanol
- early protein (Fomivirsen)
- Tromantadine
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HPV/MC
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- Imiquimod/Resiquimod
- Podophyllotoxin
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Vaccinia
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Poxviridae
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Hepatitis B (VII) |
- Nucleoside analogues/NARTIs: Entecavir
- Lamivudine
- Telbivudine
- Clevudine
- Nucleotide analogues/NtRTIs: Adefovir
- Tenofovir
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Multiple/general |
Nucleic acid inhibitors
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Interferon
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- Interferon alfa 2b
- Peginterferon alfa-2a
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Multiple/unknown
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- Ribavirin#/Taribavirin†
- Moroxydine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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cutn/syst (hppv/hiva, infl/zost/zoon)/epon
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drug (dnaa, rnaa, rtva, vacc)
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Nucleic acid constituents
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Nucleobase |
Purine (Adenine, Guanine, Hypoxanthine, Xanthine, Purine analogue) · Pyrimidine (Uracil, Thymine, Cytosine, Pyrimidine analogue)
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Nucleoside |
Ribonucleoside
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Adenosine · Guanosine · 5-Methyluridine · Uridine · Cytidine · Inosine · Xanthosine
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Deoxyribonucleoside
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Deoxyadenosine · Deoxyguanosine · Thymidine · Deoxyuridine · Deoxycytidine · Deoxyinosine · Deoxyxanthosine
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Nucleotide
(Nucleoside monophosphate) |
Ribonucleotide
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AMP, GMP, m5UMP, UMP, CMP, IMP, XMP
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Deoxyribonucleotide
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dAMP, dGMP, dTMP, dUMP, dCMP, dIMP, dXMP
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Cyclic nucleotide
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cAMP, cGMP, c-di-GMP, cADPR
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Nucleoside diphosphate |
ADP, GDP, m5UDP, UDP, CDP · dADP, dGDP, dTDP, dUDP, dCDP
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Nucleoside triphosphate |
ATP, GTP, m5UTP, UTP, CTP, ITP, XTP · dATP, dGTP, dTTP, dUTP, dCTP, dITP, dXTP
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- biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- amino acids / intermediates
- tetrapyrroles / intermediates
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UpToDate Contents
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English Journal
- The Emerging Role of Gemcitabine in Conditioning Regimens for Hematopoietic Stem Cell Transplantation.
- Wang E1, Gulbis A2, Hart JW2, Nieto Y2.
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2014 May 9. pii: S1083-8791(14)00264-X. doi: 10.1016/j.bbmt.2014.04.025. [Epub ahead of print]
- The specific combination for conditioning regimens in hematopoietic stem cell transplantation continues to be a premier area of focus in research. Although conditioning regimens have significantly evolved over time, obstacles continue to persist, including regimen-related toxicities, graft-versus-ho
- PMID 24816580
- Phase separation in phosphatidylcholine membrane caused by the presence of a pyrimidine analogue of fluphenazine with high anti-multidrug-resistance activity.
- Cieślik-Boczula K1, Swiątek P, Jaszczyszyn A, Zawilska P, Gąsiorowski K, Malinka W, Köhler G.
- The journal of physical chemistry. B.J Phys Chem B.2014 Apr 3;118(13):3605-15. doi: 10.1021/jp410882r. Epub 2014 Mar 25.
- Phenothiazine compounds are known as effective inhibitors of a multidrug resistance (MDR) of tumor cells to chemotherapeutic agents. This group consists of many important substances used in human medicine such as antipsychotic drugs in the case of fluphenazine (FPh) or chlorpromazine (CPZ). Fluphena
- PMID 24601791
- Enzymatic and structural characterization of an archaeal thiamin phosphate synthase.
- Hayashi M1, Kobayashi K2, Esaki H3, Konno H4, Akaji K2, Tazuya K5, Yamada K1, Nakabayashi T1, Nosaka K6.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Apr;1844(4):803-9. doi: 10.1016/j.bbapap.2014.02.017. Epub 2014 Feb 27.
- Studies on thiamin biosynthesis have so far been achieved in eubacteria, yeast and plants, in which the thiamin structure is formed as thiamin phosphate from a thiazole and a pyrimidine moiety. This condensation reaction is catalyzed by thiamin phosphate synthase, which is encoded by the thiE gene o
- PMID 24583237
Japanese Journal
- 2'-Deoxycytidine Decreases the Anti-tumor Effects of 5-Fluorouracil on Mouse Myeloma Cells
- ,
- Biological and Pharmaceutical Bulletin 33(6), 1024-1027, 2010
- … 2′-Deoxycytidine (dCyd), a pyrimidine nucleoside found at high concentrations in the plasma of cancer patients with a poor prognosis after chemotherapy, is considered to be a biomarker for breast cancer. … 5-Fluorouracil (5FU) is a nucleoside analog and is used as an anti-tumor agent in patients whose plasma dCyd concentrations are increased. …
- NAID 130000247973
- Synthesis and biological evaluations of new pyrrolo〔2,3-b〕pyrimidine as SDI analogs
- Guillard Jerome,Viaud-Massuard Marie-Claude
- Heterocycles 75(5), 1163-1189, 2008-05-01
- NAID 40016001270
- バイオ高分子研究の新潮流 三本鎖形成によるDNA認識のための人工塩基の開発
- 佐々木 茂貴
- 高分子 56(4), 187-190, 2007
- 近年,高次構造を有するRNAやDNAが触媒活性や調節機能を担う例が多く見いだされている。これらは細胞の置かれた時空間に依存して遺伝子発現の調節に重要な役割を果たしており,ゲノム情報の多面性が明らかになっている。したがって情報の最上流に位置するDNAに特異的に結合する分子は,バイオツールとしてさらには医薬リードとしての発展性がある。本稿では,二本鎖DNA配列認識を目指した三本鎖DNA形成分子の開発に …
- NAID 130001445361
Related Links
- Pyrimidine analogue. From Wikipedia, the free encyclopedia. Jump to: navigation , search. Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
★リンクテーブル★
[★]
- 関
- analogue、derivate、derivative、relative
linux
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INTSEARCHWORD
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内部検索単語レポート
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k
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REDIRREF
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リダイレクトされたリンク元URLレポート
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K
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FAILREF
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不成功リンク元レポート
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B
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FULLBROWSER
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ブラウザーレポート
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b
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BROWSER
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ブラウザーの概要
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OSレポート
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VHOST
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仮想ホストレポート
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REDIRVHOST
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仮想ホストリダイレクションレポート
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ON
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FAILVHOST
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仮想ホスト不成功レポート
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ON
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u
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USER
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ユーザレポート
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ON
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j
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REDIRUSER
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ユーザリダイレクションレポート
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ON
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J
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FAILUSER
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不成功ユーザレポート
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ON
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c
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STATUS
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状態コードレポート
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ON
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[★]
- 関
- analyse、analyses、analysis、analytical、analyze、ani、anus、assay、dissect