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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/10 21:36:53」(JST)

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  • Persistent modification of Nav1.9 following chronic exposure to insecticides and pyridostigmine bromide.
  • Nutter TJ1, Cooper BY2.
  • Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2014 Jun 15;277(3):298-309. doi: 10.1016/j.taap.2014.04.005. Epub 2014 Apr 13.
  • Many veterans of the 1991 Gulf War (GW) returned from that conflict with a widespread chronic pain affecting deep tissues. Recently, we have shown that a 60day exposure to the insecticides permethrin, chlorpyrifos, and pyridostigmine bromide (NTPB) had little influence on nociceptor action potential
  • PMID 24732443
  • Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity.
  • Pohanka M.
  • International journal of molecular sciences.Int J Mol Sci.2014 Jun 2;15(6):9809-25. doi: 10.3390/ijms15069809.
  • Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows tha
  • PMID 24893223
  • Intravenous immunoglobulin for prophylaxis of acute exacerbation in Myasthenia Gravis.
  • Sorgun MH1, Sener HO, Yucesan C, Yucemen N.
  • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.Neurol Sci.2014 Jun;35(6):891-6. doi: 10.1007/s10072-013-1621-4. Epub 2014 Jan 8.
  • Intravenous immunoglobulin (IVIg) treatment for acute exacerbations of Myasthenia Gravis (MG) was shown in several open-label studies. There are only two studies demonstrating the efficiency of regular intermittent IVIg therapy on MG patients who are not in their acute attack periods. Thirteen patie
  • PMID 24399309


  • Pyridostigmine が起立性低血圧に奏功した Lewy 小体型認知症の1例
  • 陣上 直人,武山 博文,松本 理器,木原 武士,高橋 良輔
  • 自律神経 = The Autonomic nervous system 49(1), 33-38, 2012-03-15
  • NAID 10030555523
  • Design and Evaluation of an Economic Taste-Masked Dispersible Tablet of Pyridostigmine Bromide, a Highly Soluble Drug with an Extremely Bitter Taste
  • Tan Qunyou,Zhang Li,Zhang Liangke [他],Teng Yongzhen,Zhang Jingqing
  • Chemical and Pharmaceutical Bulletin 60(12), 1514-1521, 2012
  • Pyridostigmine bromide (PTB) is a highly soluble and extremely bitter drug. …
  • NAID 130002459932
  • 重症筋無力症と同時発症した胸腺原発粘表皮癌の1切除例
  • 清家 彩子,長阪 智,桑田 裕美,伊藤 秀幸
  • 肺癌 50(1), 12-14, 2010
  • 背景.粘表皮癌は胸腺癌の極めて稀な1組織亜型として知られている.また重症筋無力症と胸腺癌の同時発症も極めて稀とされている.症例.62歳女性.嚥下困難にて発症.重症筋無力症と診断された.胸部CTにて前縦隔に約4.5×6 cm大の腫瘍を指摘された.重症筋無力症に対してプレドニゾロン・臭化ピリドスチグミンの内服を開始したところ,重症筋無力症は軽快した.前縦隔腫瘍も縮小し胸腺腫を疑い,胸骨正中切開による拡 …
  • NAID 130000252398


Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood–brain barrier, except possibly in stressful conditions.


Pyridostigmine, 3-[(dimethylaminocarbonyl PyridostigmineBijwerkingen Mestinon pyridostigmineAvailable pyridostigmine brands of low Pyridostigmine Tablets BP 60 mgPyridostigmine Bromide Chemical Structure

リンク元100Cases 14」「ピリドスチグミン

100Cases 14」


☆case14 複視
diplopia n. 複視
筋力低下筋無力筋脱力 muscle weakness, muscular weakness
vt. sinkのpp.
3,4-ジアミノピリジン 3,4-diaminopyridine 3,4-DAP K+チャネル阻害薬;ランバートイートン筋無力治療
43-year-old woman
cheif complaint: diplopia
present history: diplopia and holding her head up ; more marked in the evenings, for the last 3 months. difficulty of chewing. voice has become quieter. weight loss (3kg / 6months). non-smoker. drinks about 15 units/week. no regular medication.
past history: no significant previous medical illnesses.
family history: lives with her husband and three children.
診察 examination
looks well.
organ systems: normal; cardiovascular, respiratory, and abdominal systems.
muscle power; grossly normal. decrease after testing a movement repetitively.
motor function: normal; tone, coordination, reflexes and sensation.
bilateral ptosis. exacerbated by prolonged upward gaze
eye: normal; pupillary reflexes, eye movements, and funduscopy
diagnosis: myathenia gravis
differential diagnoses:
上位and/or下位運動ニューロン motor neurone disease 運動ニューロン疾患線維束性攣縮進行例では筋力低下
muscular dystrophy 筋ジストロフィー:ある種の筋肉選択的筋力低下する。家族歴がある。
dystrophia myotonica 強直性筋ジストロフィー咬筋側頭筋胸鎖乳突筋筋萎縮四肢遠位端の筋萎縮顔貌特徴的(前頭部脱毛、無表情、窪んだ頬)。家族歴ある。筋電図診断有用(急降下爆撃音)。
polymyositis 多発筋炎普通皮疹関節痛出現CK上昇筋生検診断有用
myopathy ミオパチー:甲状腺中毒性ミオパチー甲状腺機能低下症によるミオパチークッシング症候群によるミオパチーアルコール性のミオパチー
神経筋接合部non-metastatic associations of malignancy (paraneoplastic syndrome(傍腫瘍性症候群 = 腫瘍随伴症候群)のこと):胸腺腫症例の10%に重症筋無力症がみられる。ランバートイートン筋無力症候群小細胞癌関連がある。
Treatment with penicillamine (used for scleroderma or rheumatoid arthritis) may result in true autoimmune MG, but the weakness is usually mild, and recovery occurs within weeks or months after discontinuing its use.
Aminoglycoside antibiotics or procainamide can cause exacerbation of weakness in myasthenic patients; very large doses can cause neuromuscular weakness in normal individuals.
HIM = Harrison's Principles of Internal Medicine 17th Edition
CASES = 100 Cases in Clinical Medicine Second edition
IMD = 内科診断学第2版



臭化ピリドスチグミン pyridostigmine bromide
Mestinon メスチノン