pyridine-2-aldoxime methyl chloride

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英文文献

  • Sensitivity of the cat to delayed neurotoxicity induced by O-ethyl O-4-nitrophenyl phenylphosphonothioate.
  • Abou-Donia MB, Graham DG, Kinnes CG.AbstractDelayed neurotoxicity was produced in cats following the administration of either a single dermal dose of 22.5 to 225 mg/kg (0.2 to 5.0 times the LD50) or subchronic (90 days) administration of 0.5 to 2.0 mg/kg of technical grade O-ethyl O-4-nitrophenyl phenylphosphonothioate (EPN). The study showed three differences from the condition produced in the chicken: difficulty to protect from acute poisoning, slower progression of delayed neurotoxicity, and propensity for improvement. These animals received atropine sulfate and pyridine-2-aldoxime methyl chloride (PAM) to protect them against acute poisoning, but most developed signs of acute cholinergic neurotoxicity, the degree of severity being dose dependent. Also cats given small single doses of EPN showed only leg weakness, while those treated with large doses progressed to severe ataxia and death. In cats treated with subchronic dermal daily doses of EPN, the extent and permanence of injury and progression or improvement of neurologic deficit also depended on the dose size and duration of exposure. Histopathologic changes were present in the most distal portion of the longest tracts in both the central and peripheral nervous system. Ascending tracts were most affected in the cervical spinal cord, while change in the descending tracts was concentrated in the lumbosacral spinal cord. Recovery to a varying degree from delayed neurotoxicity was seen in all surviving cats. The recovery was demonstrated as improvement in clinical signs, increase in body weight, and regeneration of peripheral nerves.
  • Toxicology and applied pharmacology.Toxicol Appl Pharmacol.1983 Mar 30;68(1):54-65.
  • Delayed neurotoxicity was produced in cats following the administration of either a single dermal dose of 22.5 to 225 mg/kg (0.2 to 5.0 times the LD50) or subchronic (90 days) administration of 0.5 to 2.0 mg/kg of technical grade O-ethyl O-4-nitrophenyl phenylphosphonothioate (EPN). The study showed
  • PMID 6845375

関連リンク

EPAの化学物質情報: Pyridinium, 2-[(hydroxyimino)methyl]-1- methyl-, chloride(51 -15-0) ... 51-15-0 PYRIDINE-2-ALDOXIME METHOCHLORIDE PYRIDINE-2- CARBOXALDOXIME METHOCHLORIDE PYRIDINE-2-CARBALDOXIME ...

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The sequence of reactions shown in Bispyridinium oxides including blondi5858The oximes are thought to act by Let Me BuyRecently the new Hagedorn (H) oximes


★リンクテーブル★
関連記事chloride」「pyridine」「methyl

chloride」

  [★] 塩素イオン

WordNet   license wordnet

「any compound containing a chlorine atom」

WordNet   license wordnet

「any salt of hydrochloric acid (containing the chloride ion)」

PrepTutorEJDIC   license prepejdic

「塩化物」


pyridine」

  [★]

ピリジン

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「a toxic colorless flammable liquid organic base with a disagreeable odor; usually derived from coal」


methyl」

  [★]

メチル

Me

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「the univalent radical CH3- derived from methane」
methyl group, methyl radical




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