pyrazinamide

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ピラジナミド PZA

PZA


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/21 16:08:55」(JST)

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英文文献

  • Characterisation of pyrazinamide-resistant Mycobacterium tuberculosis strains isolated in Poland and Germany.
  • Napiórkowska A1, Rüsch-Gerdes S2, Hillemann D2, Richter E2, Augustynowicz-Kopeć E1.Author information 1Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.2The National Reference Centre for Mycobacteria, Forschungszentrim Borstel, Germany.AbstractBACKGROUND: Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug that is generally administered with isoniazid, rifampicin, ethambutol and streptomycin.
  • The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.Int J Tuberc Lung Dis.2014 Apr;18(4):454-60. doi: 10.5588/ijtld.13.0457.
  • BACKGROUND: Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug that is generally administered with isoniazid, rifampicin, ethambutol and streptomycin.OBJECTIVE: To analyse the correlation between phenotypic resistance to PZA and genotype to find out whether the great diversity in p
  • PMID 24670702
  • Highly sensitive and selective determination of pyrazinamide at poly-L-methionine/reduced graphene oxide modified electrode by differential pulse voltammetry in human blood plasma and urine samples.
  • Cheemalapati S1, Devadas B1, Chen SM2.Author information 1Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC.2Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC. Electronic address: smchen78@ms15.hinet.net.AbstractIn this current study we used electrochemically active film which contains poly-L-methionine (PMET) and electrochemically reduced graphene oxide (ERGO) on glassy carbon electrode (GCE) for pyrazinamide (PZM) detection. The electrocatalytic response of analyte at PMET/ERGO/GCE film was measured using both cyclic voltammetry (CV) and differential pulse voltammetry (DPV). In addition, electrochemical impedance studies revealed that the smaller R(ct) value observed at PMET/ERGO film modified GCE which authenticates its good conductivity and faster electron transfer rate. The prepared PMET/ERGO/GCE film exhibits excellent DPV response towards PZM and the reduction peak current increased linearly with respect to PZM concentration in the linear range between 0.4 μM to 1129 μM with a sensitivity of 0.266 μA μM(-1) cm(-2). Real sample studies were carried out in human blood plasma and urine samples, which offered good recovery and revealed the promising practicality of the sensor for PZM detection. The proposed sensor displayed a good selectivity, repeatability, sensitivity with appreciable consistency and good reproducibility. In addition, the proposed electrochemical sensor showed good results towards the commercial pharmaceutical PZM samples.
  • Journal of colloid and interface science.J Colloid Interface Sci.2014 Mar 15;418:132-9. doi: 10.1016/j.jcis.2013.11.084. Epub 2013 Dec 7.
  • In this current study we used electrochemically active film which contains poly-L-methionine (PMET) and electrochemically reduced graphene oxide (ERGO) on glassy carbon electrode (GCE) for pyrazinamide (PZM) detection. The electrocatalytic response of analyte at PMET/ERGO/GCE film was measured using
  • PMID 24461828
  • Salicylanilide pyrazinoates inhibit in vitro multidrug-resistant Mycobacterium tuberculosis strains, atypical mycobacteria and isocitrate lyase.
  • Krátký M1, Vinšová J2, Novotná E3, Stolaříková J4.Author information 1Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. Electronic address: martin.kratky@faf.cuni.cz.2Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. Electronic address: jarmila.vinsova@faf.cuni.cz.3Department of Biochemical Sciences, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. Electronic address: eva.novotna@faf.cuni.cz.4Laboratory for Mycobacterial Diagnostics and Tuberculosis, Regional Institute of Public Health in Ostrava, Partyzánské náměstí 7, 702 00 Ostrava, Czech Republic. Electronic address: jirina.stolarikova@zu.cz.AbstractThe development of antimicrobial agents represents an up-to-date topic. This study investigated in vitro antimycobacterial activity, mycobacterial isocitrate lyase inhibition and cytotoxicity of salicylanilide pyrazinoates. They may be considered being mutual prodrugs of both antimycobacterial active salicylanilides and pyrazinoic acid (POA), an active metabolite of pyrazinamide, in which these esters are likely hydrolysed without presence of pyrazinamidase/nicotinamidase. Minimum inhibitory concentrations (MICs) of the esters were within the range 0.5-8 μmol/l for Mycobacterium tuberculosis and 1-32 μmol/l for nontuberculous mycobacteria (Mycobacterium avium, Mycobacterium kansasii). All esters showed a weak inhibition (8-17%) of isocitrate lyase at the concentration of 10 μmol/l. The most active pyrazinoates showed MICs for multidrug-resistant tuberculosis strains in the range of 0.125-2 μmol/l and no cross-resistance with clinically used drugs, thus being the most in vitro efficacious salicylanilide esters with 4-chloro-2-{[4-(trifluoromethyl)phenyl]carbamoyl}phenyl pyrazine-2-carboxylate superiority (MICs⩽0.25 μmol/l). This promising activity is likely due to an additive or synergistic effect of released POA and salicylanilides. Selectivity indexes for the most active salicylanilide pyrazinoates ranged up to 64, making some derivatives being attractive candidates for the next research; 4-bromo-2-{[4-(trifluoromethyl)phenyl]carbamoyl}phenyl pyrazine-2-carboxylate showed the most convenient toxicity profile.
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Mar 12;53:1-9. doi: 10.1016/j.ejps.2013.12.001. Epub 2013 Dec 10.
  • The development of antimicrobial agents represents an up-to-date topic. This study investigated in vitro antimycobacterial activity, mycobacterial isocitrate lyase inhibition and cytotoxicity of salicylanilide pyrazinoates. They may be considered being mutual prodrugs of both antimycobacterial activ
  • PMID 24333643

和文文献

  • Primary Gastric Tuberculosis Presenting as Non-Healing Ulcer and Mimicking Crohns Disease
  • Ishii Naoki,Furukawa Keiichi,Itoh Toshiyuki,Fujita Yoshiyuki
  • Internal Medicine 50(5), 439-442, 2011
  • … The differential diagnosis included gastric tuberculosis, Crohns disease, and sarcoidosis and empiric antituberculous therapy consisting of isoniazid, rifampicin, ethambutol, and pyrazinamide was initiated. …
  • NAID 130000649855
  • Simultaneous Determination of Isoniazid, Pyrazinamide, Rifampicin and Acetylisoniazid in Human Plasma by High-Performance Liquid Chromatography
  • ZHOU Zhifeng,CHEN Lingyun,LIU Peng,SHEN Mei,ZOU Fei
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 26(11), 1133-1138, 2010-11-10
  • NAID 10027315955
  • Identification of Mycobacterium tuberculosis clinical isolates in Bangladesh by a species distinguishable multiplex PCR
  • Nakajima Chie,Rahim Zeaur,Fukushima Yukari,Sugawara Isamu,van der Zanden Adri G. M.,Tamaru Aki,Suzuki Yasuhiko
  • BMC Infectious Diseases 10, 118, 2010-05-15
  • … bovis is naturally resistant to a first line anti-tuberculosis (TB) drug, pyrazinamide, while most of the other MTC members are susceptible to this antimicrobial agent. … This result suggested the general TB treatment regimen including pyrazinamide to be the first choice in Bangladesh. …
  • NAID 120002232150

関連リンク

Pyrazinamide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Pyrazinamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: upset stomach fatigue
Structure, properties, spectra, suppliers and links for: pyrazinamide, 98-96-4. ... Antibacterial MedChem Express HY-B0271 Anti-infection MedChem Express HY-B0271 Anti-infection; MedChem Express HY-B0271 Enzyme TargetMol T1426

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★リンクテーブル★
リンク元ピラジナミド」「PZA

ピラジナミド」

  [★]

pyrazinamide PZA
pyrazinamidum
ピラジンカルボキサミド pyrazinecarboxamide
ピラマイド?, Pyramide
抗結核薬結核
  • 副作用:(多い)肝障害、高尿酸血症、関節痛
  • 厚労省が告示した治療法(結核#2009年に厚生労働省告示)ではA法で使用されている。おそらく副作用などでピラジナミドが使用できない場合にはB法を用いると思われる。

参考

  • 1. [charged] ピラジンアミド:概要 - uptodate [1]


PZA」

  [★] ピラジナミド pyrazinamide

pyrazinamide




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