WordNet

any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia" (同)alkali
(numeration system) the positive integer that is equivalent to one in the next higher counting place; "10 is the radix of the decimal system" (同)radix
the bottom side of a geometric figure from which the altitude can be constructed; "the base of the triangle"
situate as a center of operations; "we will base this project in the new lab"
a place that the runner must touch before scoring; "he scrambled to get back to the bag" (同)bag
installation from which a military force initiates operations; "the attack wiped out our forward bases" (同)base of operations
a support or foundation; "the base of the lamp" (同)pedestal, stand
(electronics) the part of a transistor that separates the emitter from the collector
a flat bottom on which something is intended to sit; "a tub should sit on its own base"
the principal ingredient of a mixture; "glycerinated gelatin is used as a base for many ointments"; "he told the painter that he wanted a yellow base with just a hint of green"; "everything she cooked seemed to have rice as the base"
the place where you are stationed and from which missions start and end (同)home
(anatomy) the part of an organ nearest its point of attachment; "the base of the skull"
the bottom or lowest part; "the base of the mountain"
illegitimate (同)baseborn
of low birth or station (`base is archaic in this sense); "baseborn wretches with dirty faces"; "of humble (or lowly) birth" (同)baseborn, humble, lowly
not adhering to ethical or moral principles; "base and unpatriotic motives"; "a base, degrading way of life"; "cheating is dishonorable"; "they considered colonialism immoral"; "unethical practices in handling public funds" (同)immoral
having or showing an ignoble lack of honor or morality; "that liberal obedience without which your army would be a base rabble"- Edmund Burke; "taking a mean advantage"; "chokd with ambition of the meaner sort"- Shakespeare; "something essentially vulgar and meanspirited in politics" (同)mean, meanspirited
(used of metals) consisting of or alloyed with inferior metal; "base coins of aluminum"; "a base metal"
debased; not genuine; "an attempt to eliminate the base coinage"
a colorless crystalline organic base containing nitrogen; the parent compound of various biologically important substances
any of several bases that are derivatives of purine
having a base; "firmly based ice"
having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes"

PrepTutorEJDIC

《文》(人や人の行動・孝えが)『卑しい』,下劣な / (金属が)質の劣った;(貨幣が)粗悪な
『基礎』,根拠 / 『基部』,基底,土台 / 『根拠地』,基地 / (野球の)塁,ベース / 主成分;塩基(酸と反応シテ塩(官)を生じる化合物) / (数学で図形の)底;底辺;基線 / (…に)…‘の'『基礎をおく』《+『名』+『on』(『upon』)+『名』》
basisの複数形

UpToDate Contents

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1. 痛風患者への尿酸生成抑制薬の投与と痛風結節の治療pharmacologic urate lowering therapy and treatment of tophi in patients with gout [show details]
… oxypurinol are pyrazolopyrimidine analogs of the purine bases hypoxanthine and xanthine, respectively . Allopurinol has multiple effects on human purine and pyrimidine metabolism: It is a competitive inhibitor …
2. 腫瘍崩壊症候群：予防および治療tumor lysis syndrome prevention and treatment [show details]
…not a purine base analog; because of the non-purine structure, febuxostat inhibits both reduced and oxidized forms of xanthine oxidase and has minimal effects on other enzymes involved in purine and pyrimidine …
3. 単純性および混合性酸塩基障害simple and mixed acid base disorders [show details]
…disturbance of acid-base status and the appropriate degree of compensation for that disturbance. The simultaneous presence of more than one acid-base disturbance is called a mixed acid-base disorder. Mixed …
4. 出産時の臍帯血酸塩基分析umbilical cord blood acid base analysis at delivery [show details]
…acid-base status and there was efflux of bicarbonate from the placenta into the maternal circulation . The bicarbonate concentration is important in defining base deficit and base excess. A base deficit …
5. 酸塩基障害におけるカリウムバランスpotassium balance in acid base disorders [show details]
…acidosis but can also occur with metabolic alkalosis and, to a lesser degree, respiratory acid-base disorders. Acid-base disturbances cause potassium to shift into and out of cells, a phenomenon called "internal …

English Journal

Structural basis for human PRDM9 action at recombination hot spots.

Patel A1, Horton JR1, Wilson GG2, Zhang X1, Cheng X1.
Genes & development.Genes Dev.2016 Feb 1;30(3):257-65. doi: 10.1101/gad.274928.115.
The multidomain zinc finger (ZnF) protein PRDM9 (PRD1-BF1-RIZ1 homologous domain-containing 9) is thought to influence the locations of recombination hot spots during meiosis by sequence-specific DNA binding and trimethylation of histone H3 Lys4. The most common variant of human PRDM9, allele A (hPR
PMID 26833727

TA-periodic ("601"-like) centromeric nucleosomes of A. thaliana.

Nibhani R1, Trifonov EN1.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2016 Feb;34(2):448-51. doi: 10.1080/07391102.2015.1028450. Epub 2015 Apr 15.
The bulk of strong nucleosomes (SNs, with visibly periodic DNA sequences) is described by consensus pattern of 5 or 6 base runs of purines alternating with similar runs of pyrimidines - RR/YY SNs. Yet, the strongest known nucleosome positioning sequence, the 601 clone of Lowary and Widom, is rather
PMID 25761985

DNA Distortion Caused by Uracil-Containing Intrastrand Cross-links.

Churchill CD, Eriksson LA, Wetmore SD.
The journal of physical chemistry. B.J Phys Chem B.2016 Feb 1. [Epub ahead of print]
Four uracil-containing intrastrand cross-links have been detected in human cells upon UV irradiation of 5-bromouracil-containing DNA, namely 5'-G[8-5]U-3', 5'-U[5-8]G-3', 5'-A[8-5]U-3' and 5'-A[2-5]U-3'. These lesions feature unique composition and connectivity compared to other intrastrand cross-li
PMID 26830475