pulmonary neuroendocrine tumor

肺神経内分泌腫瘍

WordNet

1. an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
2. of or relating to the nervous and endocrine systems (especially as they function together)

PrepTutorEJDIC

1. 肺の;肺を冒す

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2021/01/03 14:25:11」(JST)

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[Wiki en表示]

Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary parenchyma.

Pulmonary neuroendocrine tumors include a spectrum of tumors from the low-grade typical pulmonary carcinoid tumor and intermediate-grade atypical pulmonary carcinoid tumor to the high-grade pulmonary large cell neuroendocrine carcinoma (LCNEC) and pulmonary small cell carcinoma (SCLC), with significant clinical, epidemiologic and genetic differences.

Types

Pulmonary neuroendocrine tumor are classified according to tumoral grade:

• Low grade pulmonary neuroendocrine tumor: Typical pulmonary carcinoid tumour (TC; low-grade);
• Intermediate-grade pulmonary neuroendocrine tumor: Atypical pulmonary carcinoid tumour (AC; intermediate-grade)
• High-grade pulmonary neuroendocrine tumor
  • Small cell lung cancer (SCLC)
  • Large cell neuroendocrine carcinoma (LCNEC of the lung)

Low-grade nodular neuroendocrine proliferations ≥ 0.5 cm are classified as carcinoid tumors and smaller ones are called pulmonary tumorlets.

When neuroendocrine cell hyperplasia and tumorlets are extensive, they represent the rare preinvasive lesion for carcinoids known as "diffuse idiopathic pulmonary neuroendocrine cell hyperplasia".

Both LCNEC and SCLC can demonstrate histologic heterogeneity with other major histologic types of lung carcinoma, such as pulmonary adenocarcinoma or pulmonary squamous cell carcinoma, but is not characteristic of TC or AC.

Risk factor

Multiple endocrine neoplasia type I (MEN1)can be found in carcinoid tumor patients, but not those with LCNEC and SCLC.

Genetics

Genetic changes are very high in SCLC and LCNEC, but usually low for TC, intermediate for AC.

Diagnosis

The diagnosis of SCLC, TC and AC can be made by light microscopy without the need for special tests in most cases, but for LCNEC it is required to demonstrate NE differentiation by immunohistochemistry or electron microscopy.

UpToDate Contents

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• 1. 気管支神経内分泌（カルチノイド）腫瘍：疫学、危険因子、分類、組織学的検査、診断、病期分類 lung neuroendocrine carcinoid tumors epidemiology risk factors classification histology diagnosis and staging
• 2. 肺神経内分泌（カルチノイド）腫瘍：治療および予後 lung neuroendocrine carcinoid tumors treatment and prognosis
• 3. 肺悪性腫瘍の病理 pathology of lung malignancies
• 4. Practice Changing UpDates
• 5. 嚢胞性線維腺症：呼吸器症状が急性増悪した場合の治療 cystic fibrosis treatment of acute pulmonary exacerbations

English Journal

• NKX6-1 Is a Novel Immunohistochemical Marker for Pancreatic and Duodenal Neuroendocrine Tumors.

• Tseng IC1, Yeh MM, Yang CY, Jeng YM.
• The American journal of surgical pathology.Am J Surg Pathol.2015 Jun;39(6):850-7. doi: 10.1097/PAS.0000000000000435.
• NKX6-1 is a homeobox transcription factor participating in the development and regulation of endocrine function of pancreatic islets. This study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors (WDNETs). In total, 178 primary and 26 metastati
• PMID 25871618

• Solitary Choroidal Metastasis From Atypical Carcinoid of the Lung Detected by 68Ga DOTATATE PET/CT.

• Rapicetta C1, Falco F, Roncali M, Treglia G, Carbonelli C, Paci M, Marchi S, Lococo F.
• Clinical nuclear medicine.Clin Nucl Med.2015 Jun;40(6):e319-20. doi: 10.1097/RLU.0000000000000660.
• A 71-year-old woman with a history of surgically treated bronchial atypical carcinoid underwent Ga DOTATATE PET/CT for restaging. Somatostatin receptor PET/CT revealed a focal area of mild radiopharmaceutical uptake corresponding to a thickening of the right choroid. No other areas of abnormal trace
• PMID 25546202

• Neuroendocrine gastro-enteropancreatic tumors - from eminence based to evidence-based medicine - A Scandinavian view.

• Öberg K1.
• Scandinavian journal of gastroenterology.Scand J Gastroenterol.2015 Jun;50(6):727-39. doi: 10.3109/00365521.2015.1033001. Epub 2015 Apr 8.
• Neuroendocrine tumors (NETs) comprise a heterogenous group of neoplasms with variable clinical expression and progression. The primary tumors most frequently occur in the lungs, intestine and the pancreas. The NET incidence is approximately 6.1/100,000 per year with a prevalence higher than 35/100,0
• PMID 25855088

Japanese Journal

• 多発小腸転移により発見された肺大細胞神経内分泌癌の1例

• 片山 公実子,熊本 牧子,大屋 貴広,森田 剛平,大林 千穂,木村 弘
• 肺癌 55(2), 113-118, 2015
• 背景．肺癌の小腸転移例は,発見されにくく，発見時に全身状態が不良のため化学療法が施行可能な症例は多くない．症例．66歳男性．上腹部痛，黒色便，貧血で近医を受診しCTにて左下葉に径6 cm大の腫瘍，小腸に多発ポリープと腸重積，腸閉塞を認めた．ダブルバルーン小腸内視鏡検査を施行したところ，径5 mm～3 cmの亜有茎性隆起が多発していた．内視鏡下の生検組織とその後施行された小腸部分切除組織の病理所見は …
• NAID 130005071160

• 3つの組織型を認めた異時性多発非小細胞肺癌の1切除例

• 岡田 晃斉,佐々木 正人,左近 佳代,池田 岳史,今村 好章
• 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 27(2), 164-169, 2013-03-15
• 間質性肺炎は肺癌発症の危険因子であり，異時性に肺癌が多発することもある．しかし，3つの組織型を発症した報告は稀である．今回，異時性に3つの組織型を発症した間質性肺炎合併肺癌症例を経験した．症例は66歳，女性．初回治療から約3年の経過で，扁平上皮癌，腺癌，大細胞神経内分泌癌の3組織型を認める肺癌を発症した．3回の手術加療を行い，現在再発巣に対し加療中である．間質性肺炎に肺癌が合併した場合，間質性肺炎 …
• NAID 10031138885

• 初回治療より9年後に再発転移が疑われた喉頭原発神経内分泌腫瘍の1例

• 徳留 卓俊,嶋根 俊和,小倉 千佳,川口 顕一朗,河村 陽二郎,下鑪 裕子,中村 泰介,五味渕 寛,小林 斉,三邉 武幸,楯 玄秀
• 昭和学士会雑誌 73(1), 38-42, 2013
• 喉頭原発の神経内分泌腫瘍は比較的稀な疾患で，治療後早期にリンパ節転移，遠隔転移をきたしやすいため，長期の経過を経て再発や転移した例は報告が少ない．今回われわれは喉頭蓋に発生した神経内分泌腫瘍が外科的治療後9年経過し原発再発，肺転移をきたしたと考えられた症例を経験したので報告する．症例は65歳女性で，咽頭痛を訴え2002年2月に当科を受診した．喉頭蓋に腫瘤性病変を認めたため，2003年5月に腫瘍摘出 …
• NAID 130005056843

Related Links

• Lung Cancer: Pulmonary Neuroendocrine Tumors | Memorial ...

Neuroendocrine cells help heal the thin layer of tissue — known as the epithelium — that lines internal organs and other surfaces inside the body after injury, including injury from infection. Occasionally, however ...

• What is a pulmonary carcinoid/neuroendocrine tumor?

A pulmonary, lung or bronchial carcinoid is a rare tumor of the lung that arises from the cells lining the airways. These tumors are very different from the more common lung cancers seen in smokers and have a much better outcome in ...

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★リンクテーブル★

リンク元	「肺神経内分泌腫瘍」
関連記事	「pulmonary」「tumor」

「肺神経内分泌腫瘍」

　　[★]

英

pulmonary neuroendocrine tumor

「pulmonary」

　　[★]

• adj.

• 肺の、肺性の

関

lung、pneumo

　

「tumor」

　　[★]

• n.

• 腫瘍、腫瘤、腫脹