WordNet
- any malignant tumor derived from epithelial tissue; one of the four major types of cancer
PrepTutorEJDIC
- がん,がん腫
- 肺の;肺を冒す
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- 1. 肺癌の危険因子、病理、および臨床症状の概要 overview of the risk factors pathology and clinical manifestations of lung cancer
- 2. 肺癌の初期評価、治療、および予後の概要 overview of the initial evaluation treatment and prognosis of lung cancer
- 3. 肺癌が疑われる患者の初期評価、診断、および病期分類の概要 overview of the initial evaluation diagnosis and staging of patients with suspected lung cancer
- 4. ステージI～II非小細胞肺癌のマネージメント management of stage i and stage ii non small cell lung cancer
- 5. 進行非小細胞肺癌の治療の役割 overview of the treatment of advanced non small cell lung cancer
English Journal
- Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes.
- Gonzalez L, Lukamowicz-Rajska M, Thomassen LC, Kirschhock CE, Leyns L, Lison D, Martens JA, Elhajouji A, Kirsch-Volders M.Author information Laboratory for Cell Genetics, Vrije Universiteit Brussel , Brussels , Belgium.AbstractAbstract Serum proteins have been shown to modulate the cytotoxic and genotoxic responses to nanomaterials. The aim was to investigate the influence of serum on the induction of micronuclei (MN) by nanoparticles (NPs) of different sizes. Therefore, A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles (SNPs) were used as models. Assessment of the cell viability, cell cycle changes and induction of MN by SNPs ranging from 12 to 174 nm was performed in presence or absence of serum, applying the in vitro flow cytometry-based MN assay. Here, it has been demonstrated that serum has an influence on these end points, with a lower cell viability in absence of serum compared with the presence of serum. Further, cell cycle changes, specifically, G1 and S-phase arrest, were observed in absence of serum for four out of six SNPs tested. A size-dependent MN induction was observed: larger SNPs being more active in absence of serum. In addition, the serum influence was characterised by a size-dependency for cytotoxic and genotoxic effects, with a higher influence of serum for smaller particles. The data indicate that the in vitro micronucleus assay in presence and absence of serum could be advised for hazard assessment because it demonstrates a higher sensitivity in serum-free conditions than in conditions with serum. However, this recommendation applies only if the cell line used is able to proliferate under serum-free conditions because cell division is a prerequisite for MN expression.
- Nanotoxicology.Nanotoxicology.2014 Dec;8:876-84. doi: 10.3109/17435390.2013.842266.
- Abstract Serum proteins have been shown to modulate the cytotoxic and genotoxic responses to nanomaterials. The aim was to investigate the influence of serum on the induction of micronuclei (MN) by nanoparticles (NPs) of different sizes. Therefore, A549 human lung carcinoma cells and amorphous monod
- PMID 24040841
- Smoking and smoking cessation in relation to the development of co-existing non-small cell lung cancer with chronic obstructive pulmonary disease.
- Zhai R, Yu X, Wei Y, Su L, Christiani DC.Author information Department of Environmental Health, Harvard School of Public Health, Boston, MA.AbstractPrevious studies have identified a mixed-phenotype of non-small cell lung cancer (NSCLC) with co-existing chronic obstructive pulmonary disease (COPD). Although NSCLC and COPD share a common risk factor in smoking, whether and how smoking may contribute to the coexistence of NSCLC with COPD (NSCLC-COPD) is unclear. Our study suggests that cigarette smoking is the major risk factor for the development of NSCLC-COPD, especially in females and among patients with squamous cell carcinoma subtype.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Feb;134(4):961-70. doi: 10.1002/ijc.28414. Epub 2013 Aug 29.
- Previous studies have identified a mixed-phenotype of non-small cell lung cancer (NSCLC) with co-existing chronic obstructive pulmonary disease (COPD). Although NSCLC and COPD share a common risk factor in smoking, whether and how smoking may contribute to the coexistence of NSCLC with COPD (NSCLC-C
- PMID 23921845
- Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer.
- Belmont L, Rabbe N, Antoine M, Cathelin D, Guignabert C, Kurie J, Cadranel J, Wislez M.Author information Service de Pneumologie, AP-HP, Hôpital Tenon, Paris, France; Equipe de Recherche 2, GRC UPMC-04, Université Paris 6 Pierre et Marie Curie, Service de Pneumologie, Hôpital Tenon, Paris, France.AbstractToll-like receptors (TLRs) play a crucial role in the innate and adaptive immune responses against microbial infection, tissue injury and cancer. Ligands of TLR9 have been developed as therapy in non-small-cell lung carcinoma (NSCLC). However, phase III clinical trials in metastatic NSCLC were negative. Our objective was to determine whether TLR9 affects tumor growth. We generated a mouse model of lung adenocarcinoma (ADC) mutated for K-ras (K-ras(LA1) ), with and without TLR9 inactivation (K-ras(LA1) TLR9(-/-) and K-ras(LA1) TLR9(+/+) , respectively). TLR9 was functionally expressed only in mononuclear cells of K-ras(LA1) TLR9(+/+) mice. These mice had significantly worse survival and a higher tumor burden than K-ras(LA1) TLR9(-/-) mice. Lung tumors were analyzed for 24 cytokines/growth factors using Bio-Plex multiplex bead-based assays. Factor VIII was assessed by immunochemistry. Tumors from K-ras(LA1) TLR9(+/+) mice were characterized by an angiogenic phenotype with higher concentrations of vascular endothelial growth factor (VEGF) and higher microvessel density than from K-ras(LA1) TLR9(-/-) mice. LKR13 cells, an ADC cell line derived from K-ras(LA1) mice, were subcutaneously injected into TLR9(-/-) and TLR9(+/+) mice. Syngeneic tumors regressed in TLR9(-/-) but not in TLR9(+/+) mice. Peripheral blood mononuclear cells from TLR9(-/-) mice released less VEGF than those from TLR9(+/+) mice. In 61 patients with early-stage NSCLC, TLR9 was expressed in mononuclear cells that infiltrated tumors, as assessed by immunochemistry, and contributed to worse survival. Our results suggest that TLR9 expression in mononuclear cells was associated with an angiogenic phenotype and promoted lung cancer progression. These findings may aid clinical development of TLR9 ligands to treat cancers.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Feb;134(4):765-77. doi: 10.1002/ijc.28413. Epub 2013 Sep 4.
- Toll-like receptors (TLRs) play a crucial role in the innate and adaptive immune responses against microbial infection, tissue injury and cancer. Ligands of TLR9 have been developed as therapy in non-small-cell lung carcinoma (NSCLC). However, phase III clinical trials in metastatic NSCLC were negat
- PMID 23913633
Japanese Journal
- じん肺法と産業医(第2部「職場環境と有害要因」,<特集>産業医と労働安全衛生法四十年)
- 森本 泰夫
- 産業医科大学雑誌 35(特集), 113-119, 2013-10-01
- じん肺法は,主にじん肺健診などの健康管理やその事後処置に関する項目が掲載されており,時代とともに健診項目の評価手法・解釈の変更が行われた。主な変更点は,胸部の画像としてCRやDR画像を認めたこと,肺機能障害の評価を日本人の基準値を用いて行ったこと,じん肺の合併症に肺がんが加わったことなどである。産業医は,これらの変更に柔軟に対応し,じん肺を未然に防ぐために粉じん職場における労働衛生管理を徹底するこ …
- NAID 110009674362
- 臨床と研究 腎癌肺転移巣の組織学的異型度が画像診断に及ぼす影響
- 吉田 光輝,先山 正二,梶浦 耕一郎 [他]
- 胸部外科 = The Japanese journal of thoracic surgery 66(11), 996-999, 2013-10
- NAID 40019810151
- 肺原発と思われた印環細胞型腺癌の気管・気管支内転移の1例
- 藤原 尚子,三輪 千尋,岩井 悠希,野村 基子,白石 守,渡辺 恭孝,小山 信一郎
- 気管支学 : 日本気管支研究会雑誌 35(5), 493-498, 2013-09-25
- 背景.肺原発の印環細胞癌はまれな組織型であり,その報告は少ない.症例. 55歳男性,検診の胸部単純X線写真で網状影,腹部超音波で肝腫瘤性病変を指摘され,肺の炎症性変化と肝血管腫と診断された.しかし,1年後肺および肝臓の病変が増悪したため,精査目的に来院となった.肝生検で印環細胞型腺癌と診断され,また胸部CTでは小粒状影と小葉間隔壁の肥厚よりサルコイドーシスを疑われ,気管支鏡検査を施行した.その結果 …
- NAID 110009661331
Related Links
- A pulmonary carcinoma or “neoplasm”, also referred to as lung cancer, is a malignant tumor that is associated with an abnormal growth of cells in the tissues of either one or both the lungs. It has been reported by the American ...
- Lung, cat. Neoplastic cells aggregate within pulmonary alveoli, and invade into a bronchus (white arrow) and the surrounding lung tissue (black arrows). ... Skeletal muscle, cat. Neoplastic epithelial cells with prominent atypia form ...
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★リンクテーブル★
| リンク元 | 「pulmonary cancer」「cancer of the lung」「肺がん」 |
| 拡張検索 | 「ovine pulmonary carcinoma」 |
| 関連記事 | 「pulmonary」 |
「pulmonary cancer」
- 関
- cancer of the lung、carcinoma of lung、lung cancer、lung carcinoma、lung neoplasm、pulmonary carcinoma、pulmonary neoplasm
「cancer of the lung」
- 関
- carcinoma of lung、lung cancer、lung carcinoma、lung neoplasm、pulmonary cancer、pulmonary carcinoma、pulmonary neoplasm
「肺がん」
「ovine pulmonary carcinoma」
「pulmonary」
- adj.
- 肺の、肺性の