関: proparacaine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/19 18:46:00」(JST)

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Proxymetacaine (INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester group.

Clinical pharmacology[edit]

Indications and usage[edit]

Proxymetacaine hydrochloride ophthalmic solution (eye drops) is indicated for procedures such as tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva.

Warnings[edit]

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss.

Mechanism of action[edit]

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.

How supplied[edit]

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

English Journal

Proparacaine hydrochloride topical drop and intracameral 0.5% lignocaine for phacotrabeculectomy in patients with primary open angle glaucoma.

Joshi RS1.
Middle East African journal of ophthalmology.Middle East Afr J Ophthalmol.2014 Jul-Sep;21(3):210-5. doi: 10.4103/0974-9233.134669.
AIM: To compare the efficacy and safety of 0.5% intracameral lignocaine to 1% intracameral lignocaine prior to phacotrabeculectomy.STUDY DESIGN: Prospective, comparative, observational, and interventional study.SETTING: Tertiary eye care center in central India.MATERIALS AND METHODS: This study was
PMID 25100903

Non-antiepileptic drugs for trigeminal neuralgia.

Zhang J1, Yang M, Zhou M, He L, Chen N, Zakrzewska JM.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2013 Dec 3;12:CD004029. doi: 10.1002/14651858.CD004029.pub4.
BACKGROUND: Trigeminal neuralgia was defined by the International Association for the Study of Pain as a sudden, usually unilateral, severe, brief, stabbing recurrent pain in the distribution of one or more branches of the fifth cranial nerve. Standard treatment is with anti-epileptic drugs. Non-ant
PMID 24297506

Assessing patient satisfaction with cataract surgery under topical anesthesia supplemented by intracameral lidocaine combined with sedation.

Fernandes MB, Souza RV, Vasconcelos GC, Ribeiro KG, Andrade BB, Fernandes CR.
Arquivos brasileiros de oftalmologia.Arq Bras Oftalmol.2013 Nov-Dec;76(6):345-9.
PURPOSE: Ocular akinesia, the use of anticoagulants, and patient collaboration are some of the factors that must be taken into consideration when choosing the appropriate anesthesia for phacoemulsification cataract surgery. The satisfaction of patients with the use of topical anesthesia and consciou
PMID 24510080

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リンク元	「proparacaine」「プロキシメタカイン」

「proparacaine」

Proxymetacaine
Systematic (IUPAC) name
	2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C (US)
Legal status	?
Routes	Topical (eye drops)
Pharmacokinetic data
Metabolism	Plasma
Identifiers
CAS number	499-67-2; 5875-06-9 (HCl)
ATC code	S01HA04
PubChem	CID 4935
DrugBank	DB00807
ChemSpider	4766
UNII	B4OB0JHI1X
KEGG	D08448
ChEMBL	CHEMBL1196
Chemical data
Formula	C16H26N2O3
Mol. mass	294.389 g/mol
	SMILES O=C(OCCN(CC)CC)c1ccc(OCCC)c(c1)N;
	InChI InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3 ; Key:KCLANYCVBBTKTO-UHFFFAOYSA-N ;
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