関: c-Raf protein、Raf-1 kinase

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
in favor of a proposition, opinion, etc.
an argument in favor of a proposal
in favor of (an action or proposal etc.); "a pro vote"
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 18th letter of the Roman alphabet (同)r
ancient Egyptian sun god with the head of a hawk; a universal creator; he merged with the god Amen as Amen-Ra to become the king of the gods (同)Re

PrepTutorEJDIC

carbonの化学記号
=professional
賛成論;賛成票(者) / 賛成して
蛋白(たんばく)質
resistance / 17歳以下父兄同伴映画の表示 / rook
radiumの化学記号

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1. 前立腺癌の分子生物学molecular biology of prostate cancer [show details]
… belongs to a family of receptors that includes the HER2 protein (c-erbB-2),… somatic alterations that result in amplification of presumed oncogenes (eg,…
2. 胃癌の病理および分子学的病因pathology and molecular pathogenesis of gastric cancer [show details]
…infection, while the relationship of many to H. pylori infection remains unresolved. Oncogenes — Several oncogenes are overexpressed in various stages of gastric carcinogenesis, although none has consistently …
3. 消化管間質腫瘍（GIST）の疫学、分類、臨床症状、予後の特徴、診断方法epidemiology classification clinical presentation prognostic features and diagnostic work up of gastrointestinal stromal tumors gist [show details]
…with the transmembrane KIT receptor tyrosine kinase, the product of the KIT protooncogene (the human homolog of the viral oncogene v-KIT, and therefore, sometimes referred to as c-KIT) . At the same time …
4. 小児の褐色細胞腫と傍神経節腫pheochromocytoma and paraganglioma in children [show details]
… Multiple endocrine neoplasia type 2A or 2B (MEN2) – Associated with mutations in the RET proto-oncogene. Approximately 50 percent of cases of MEN2 include pheochromocytoma . Neurofibromatosis type …
5. 骨髄増殖性腫瘍の概要overview of the myeloproliferative neoplasms [show details]
…JAK2, CALR, and MPL, the genes that are most commonly mutated in PV, ET, and PMF are : TET2 (TET oncogene family member 2) ASXL1 (Additional sex combs 1) DNMT3A (a DNA methyltransferase) CBL (Casitas B-lineage…

English Journal

Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.

Leontovich AA, Zhang S, Quatraro C, Iankov I, Veroux PF, Gambino MW, Degnim A, McCubrey J, Ingle J, Galanis E, D'Assoro AB.SourceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.
International journal of oncology.Int J Oncol.2012 Jun;40(6):1858-64. doi: 10.3892/ijo.2012.1407. Epub 2012 Mar 19.
Aberrant activation of the Raf/MEK/MAPK pathway plays a key role in breast cancer development and progression. Dysregulation of Raf/MEK/MAPK oncogenic signaling often results from overexpression of the HER-2/Neu tyrosine kinase receptor leading to chemoendocrine r
PMID 22447278

Interleukin-6, osteopontin and Raf/MEK/ERK signaling modulate the sensitivity of human myeloma cells to alkylphosphocholines.

Yosifov DY, Reufsteck C, Konstantinov SM, Berger MR.SourceDepartment of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria. deyanyosifov@abv.bg
Leukemia research.Leuk Res.2012 Jun;36(6):764-72. Epub 2012 Mar 14.
Alkylphosphocholines are highly active against multiple myeloma (MM) cells in vitro and are devoid of myelotoxicity. Little is known about the determinants of MM cell responsiveness or resistance to these drugs. In this study we investigated the effects of disease-relevant cytokines, such as interle
PMID 22421411

Japanese Journal

Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma

HWANG Yeo Hyeon,CHOI Jong Young,KIM Soyoun,CHUNG Eun Sun,KIM Taeuk,KOH Sang Seok,LEE Bogman,BAE Si Hyun,KIM Jin,PARK Young Min
Hepatology research : the official journal of the Japan Society of Hepatology 29(2), 113-121, 2004-06-01
NAID 10018024343

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products