癌原遺伝子産物B-Raf
WordNet
- in favor of a proposition, opinion, etc.
- an argument in favor of a proposal
- in favor of (an action or proposal etc.); "a pro vote"
- the 2nd letter of the Roman alphabet (同)b
- the blood group whose red cells carry the B antigen (同)type_B, group B
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 18th letter of the Roman alphabet (同)r
- ancient Egyptian sun god with the head of a hawk; a universal creator; he merged with the god Amen as Amen-Ra to become the king of the gods (同)Re
PrepTutorEJDIC
- =professional
- 賛成論;賛成票(者) / 賛成して
- 蛋白(たんばく)質
- resistance / 17歳以下父兄同伴映画の表示 / rook
- radiumの化学記号
UpToDate Contents
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English Journal
- Absence of microsatellite instability and BRAF (V600E) mutation in testicular germ cell tumors.
- Cárcano FM1,2, Lengert AH3,4, Vidal DO3,4, Scapulatempo Neto C3,5, Queiroz L6, Marques H6, Baltazar F7,8, Berardinelli GN3, Martinelli CM3, da Silva EC5, Reis RM3,7,8, Lopes LF3,4.
- Andrology.Andrology.2016 Sep;4(5):866-72. doi: 10.1111/andr.12200. Epub 2016 May 6.
- Testicular germ cell tumors (TGCT) are the most common malignant neoplasm in young men. DNA mismatch repair deficiency can lead to microsatellite instability (MSI), an important mechanism of genetic instability. A mutation of the BRAF gene has been implicated in the pathogenesis of several solid tum
- PMID 27153176
- Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
- Shen CH1, Kim SH1, Trousil S1, Frederick DT2, Piris A3, Yuan P1, Cai L1, Gu L4, Li M1, Lee JH1, Mitra D1, Fisher DE1,2, Sullivan RJ2, Flaherty KT2, Zheng B1.
- Nature medicine.Nat Med.2016 Aug 8. doi: 10.1038/nm.4155. [Epub ahead of print]
- The protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and therapeutic target in melanoma. Inhibitors of BRAF (BRAFi) have shown high response rates and extended survival in patients with melanoma who bear tumors that express mutations encoding BRAF proteins m
- PMID 27500726
- Side-effects of checkpoint inhibitor-based combination therapy.
- Kourie HR1, Klastersky JA.
- Current opinion in oncology.Curr Opin Oncol.2016 Jul;28(4):306-13. doi: 10.1097/CCO.0000000000000295.
- PURPOSE OF REVIEW: After the dramatic and often long-standing response rates of checkpoint inhibitors as single agents, the new era for checkpoint inhibitors is combined therapy (either with other checkpoint inhibitors, chemotherapies, targeted therapies or immunotherapies) that is aiming to do even
- PMID 27136134
Japanese Journal
- Genetic alterations in melanocytic tumors
- TAKATA Minoru,SAIDA Toshiaki
- Journal of dermatological science 43(1), 1-10, 2006-07-01
- NAID 10020549141
Related Links
- This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and ...
- The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. This protein is part of a signaling pathway known as the RAS/MAPK pathway, which controls ...
- This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been ...
Related Pictures
★リンクテーブル★
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- 英
- proto-oncogene protein B-Raf
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- Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する
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- 関
- oncogene product、oncoprotein
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