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- 1. 肥満細胞由来のメディエーター mast cell derived mediators
- 2. 不安定プラークの病理および病因 pathology and pathogenesis of the vulnerable plaque
- 3. 肝線維症の病因 pathogenesis of hepatic fibrosis
- 4. 再発性多発性軟骨炎の病因および発症機序 etiology and pathogenesis of relapsing polychondritis
- 5. 変形性関節症の病因 pathogenesis of osteoarthritis
- Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.
- Nigam SK, Bush KT.Author information Department of Medicine, University of California, La Jolla, San Diego, CA, 92093-0693, USA, email@example.com.AbstractThe development of branched epithelial organs, such as the kidney, mammary gland, lung, pancreas, and salivary gland, is dependent upon the involvement and interaction of multiple regulatory/modulatory molecules, including soluble growth factors, extracellular matrix components, and their receptors. How the function of these molecules is coordinated to bring about the morphogenetic events that regulate iterative tip-stalk generation (ITSG) during organ development remains to be fully elucidated. A common link to many growth factor-dependent morphogenetic pathways is the involvement of variably sulfated heparan sulfates (HS), the glycosaminoglycan backbone of heparan sulfate proteoglycans (HSPG) on extracellular surfaces. Genetic deletions of HS biosynthetic enzymes (e.g., C5-epimerase, Hs2st), as well as considerable in vitro data, indicate that variably sulfated HS are essential for kidney development, particularly in Wolffian duct budding and early ureteric bud (UB) branching. A role for selective HS modifications by enzymes (e.g., Ext, Ndst, Hs2st) in stages of branching morphogenesis is also strongly supported for mammary gland ductal branching, which is dependent upon a set of growth factors similar to those involved in UB branching. Taken together, these studies provide support for the notion that the specific spatio-temporal HS binding of growth factors during the development of branched epithelial organs (such as the kidney, mammary gland, lung and salivary gland) regulates these complex processes by potentially acting as "morphogenetic switches" during the various stages of budding, branching, and other developmental events central to epithelial organogenesis. It may be that two or more growth factor-selective HS interactions constitute a functionally equivalent morphogenetic switch; this may help to explain the paucity of severe branching phenotypes with individual growth factor knockouts.
- Pediatric nephrology (Berlin, Germany).Pediatr Nephrol.2014 Apr;29(4):727-35. doi: 10.1007/s00467-013-2725-z. Epub 2014 Feb 2.
- The development of branched epithelial organs, such as the kidney, mammary gland, lung, pancreas, and salivary gland, is dependent upon the involvement and interaction of multiple regulatory/modulatory molecules, including soluble growth factors, extracellular matrix components, and their receptors.
- PMID 24488503
- Natural and synthetic polymers for wounds and burns dressing.
- Mogoşanu GD1, Grumezescu AM2.Author information 1Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania.2Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. Electronic address: firstname.lastname@example.org.AbstractIn the last years, health care professionals faced with an increasing number of patients suffering from wounds and burns difficult to treat and heal. During the wound healing process, the dressing protects the injury and contributes to the recovery of dermal and epidermal tissues. Because their biocompatibility, biodegradability and similarity to macromolecules recognized by the human body, some natural polymers such as polysaccharides (alginates, chitin, chitosan, heparin, chondroitin), proteoglycans and proteins (collagen, gelatin, fibrin, keratin, silk fibroin, eggshell membrane) are extensively used in wounds and burns management. Obtained by electrospinning technique, some synthetic polymers like biomimetic extracellular matrix micro/nanoscale fibers based on polyglycolic acid, polylactic acid, polyacrylic acid, poly-ɛ-caprolactone, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, exhibit in vivo and in vitro wound healing properties and enhance re-epithelialization. They provide an optimal microenvironment for cell proliferation, migration and differentiation, due to their biocompatibility, biodegradability, peculiar structure and good mechanical properties. Thus, synthetic polymers are used also in regenerative medicine for cartilage, bone, vascular, nerve and ligament repair and restoration. Biocompatible with fibroblasts and keratinocytes, tissue engineered skin is indicated for regeneration and remodeling of human epidermis and wound healing improving the treatment of severe skin defects or partial-thickness burn injuries.
- International journal of pharmaceutics.Int J Pharm.2014 Mar 25;463(2):127-36. doi: 10.1016/j.ijpharm.2013.12.015. Epub 2013 Dec 22.
- In the last years, health care professionals faced with an increasing number of patients suffering from wounds and burns difficult to treat and heal. During the wound healing process, the dressing protects the injury and contributes to the recovery of dermal and epidermal tissues. Because their bioc
- PMID 24368109
- A5.5 SMOC2 modulates chondrogenesis by interfering with WNT and BMP signalling.
- Cailotto F, Luyten FP, Lories RJ.Author information Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development & Regeneration, KU Leuven, Belgium.AbstractBACKGROUND AND OBJECTIVES: A proteomic analysis of cartilage revealed an increase in SPARC-related modular calcium binding protein-2 (SMOC2) in patients with osteoarthritis (OA). SMOC2 was originally isolated from a chondrogenic extract of articular cartilage together with GDF5 and FRZB, proteins associated with OA. We investigated SMOC2 in chondrocyte differentiation.
- Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A65. doi: 10.1136/annrheumdis-2013-205124.147.
- BACKGROUND AND OBJECTIVES: A proteomic analysis of cartilage revealed an increase in SPARC-related modular calcium binding protein-2 (SMOC2) in patients with osteoarthritis (OA). SMOC2 was originally isolated from a chondrogenic extract of articular cartilage together with GDF5 and FRZB, proteins as
- PMID 24489274
- 1F34 家兎膝関節軟骨の摩擦特性と微視構造特性
- バイオエンジニアリング講演会講演論文集 2016(28), "1F34-1"-"1F34-5", 2016-01-09
- NAID 110010052099
- 日大医学雑誌 75(1), 16-21, 2016
- NAID 130005165518
- 有機合成化学協会誌 74(3), 206-218, 2016
- NAID 130005151890
- 16th Proteoglycan Forum Abstracts Special Commemorative Lectures for 15th Anniversary Abstracts Abstracts IUBMB Satellite: Extracellular Glycomatrix in Health and Disease Abstracts The Third Symposium of Japanese and ...
- Proteoglycans and Glycosaminoglycans are active regulators of cell function, participate in cell-matrix interactions and play an important biological role in fibroblasts proliferation, differentiation and migration by effectively modulating ...