protein farnesylation

出典: meddic

タンパク質ファルネシル化蛋白質ファルネシル化

protein geranylgeranylationprotein isoprenylationprotein prenylation

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英文文献

  • Molecular modeling, in silico screening and molecular dynamics of PfPRL-PTP of P. falciparum for identification of potential anti-malarials.
  • Patel S1, Joshi D1, Soni R1, Sharma D1, Bhatt TK1.
  • Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2015 Sep 22:1-15. [Epub ahead of print]
  • Millions of deaths occur every year due to malaria. Growing resistance against existing drugs for treatment of malaria has exaggerated the problem further. There is an intense demand of identifying drug targets in malaria parasite. PfPRL-PTP protein is PRL group of phosphatase, and one of the intere
  • PMID 26313238
  • Structure-activity analysis and antiprion mechanism of isoprenoid compounds.
  • Hamanaka T1, Nishizawa K1, Sakasegawa Y1, Teruya K1, Doh-Ura K2.
  • Virology.Virology.2015 Sep 21;486:63-70. doi: 10.1016/j.virol.2015.09.002. [Epub ahead of print]
  • The prion strain-specific mechanism by which normal prion protein is converted to abnormal prion protein remains largely unknown. This study found that insect juvenile hormone III reduced abnormal prion protein levels only in cells infected with the RML prion. We conducted a structure-activity analy
  • PMID 26402376
  • Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells.
  • Vilimanovich U1, Bosnjak M1, Bogdanovic A2, Markovic I3, Isakovic A3, Kravic-Stevovic T1, Mircic A1, Trajkovic V4, Bumbasirevic V5.
  • European journal of pharmacology.Eur J Pharmacol.2015 Sep 8;765:415-428. doi: 10.1016/j.ejphar.2015.09.004. [Epub ahead of print]
  • Statins exhibit anti-leukemic properties due to suppression of the mevalonate pathway by the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, and subsequent depletion of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate. We investigated the role of autophagy, a contro
  • PMID 26358205

和文文献

  • Lysophosphatidylcholine Increases Na^+/Ca^<2+> Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells
  • Maeda Sachiko,Sakamoto Kazuho,Matsuoka Isao [他],IWAMOTO Takahiro,KIMURA Junko
  • Journal of pharmacological sciences 109(4), 565-572, 2009-04-20
  • … Conversely, fluvastatin (Flv), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, decreased NCX1 mRNA and protein expression by inhibiting RhoB. … We conclude that geranylgeranylation, but not farnesylation, of RhoB mediates LPC-induced NCX1 mRNA increase in H9c2 cells. …
  • NAID 10025735890
  • A novel role for protein farnesylation in plant innate immunity
  • P-37 ファルネシルトランスフェラーゼ阻害剤Andrastin類の合成研究(ポスター発表の部)
  • 岡本 玲,徳山 英利,井原 正隆,豊田 真弘
  • 天然有機化合物討論会講演要旨集 (48), 349-354, 2006-09-15
  • … Ras proteins are subjected to posttranslational farnesylation at a cysteine the fourth residue from the C-terminus, in which protein farnesyltransferase (PFTase) is concerned. … Andrastins A-D are unique meroterpenoids (mixed polyketide-terpenoid) and novel protein farnesyltransferase inhibitors. … Since farnesylation is essential for the transforming activity of mutated Ras proteins, andrastins are expected to be promising antitumor agents. …
  • NAID 110006682679

関連リンク

1. Cancer Cell. 2005 Apr;7(4):297-300. Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy. Sebti SM(1). Author information: (1)Drug Discovery Program, H. Lee Moffitt ...
Protein farnesylation is a posttranslational modification that facilitates the binding of proteins to membrane surfaces. Protein farnesyltransferase catalyzes the addition of a 15-carbon farnesyl lipid to proteins containing a carboxyl ...

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★リンクテーブル★
リンク元蛋白質ファルネシル化」「protein geranylgeranylation」「protein isoprenylation」「protein prenylation」「タンパク質ファルネシル化
関連記事protein」「farnesylation

蛋白質ファルネシル化」

  [★]

protein farnesylation
タンパク質プレニル化タンパク質ファルネシル化タンパク質イソプレニル化タンパク質ゲラニルゲラニル化


protein geranylgeranylation」

  [★]

タンパク質ゲラニルゲラニル化

protein farnesylationprotein isoprenylationprotein prenylation


protein isoprenylation」

  [★]

タンパク質イソプレニル化

protein farnesylationprotein geranylgeranylationprotein prenylation


protein prenylation」

  [★]

タンパク質プレニル化

protein farnesylationprotein geranylgeranylationprotein isoprenylation


タンパク質ファルネシル化」

  [★]

protein farnesylation
蛋白質ファルネシル化


protein」

  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic

「蛋白(たんばく)質」


farnesylation」

  [★]

farnesylategeranylgeranylationisoprenylationprenylation




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