protein L-isoaspartyl methyltransferase

出典: meddic


protein D-aspartate-L-isoaspartate methyltransferase

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  • Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.
  • Carter WG1, Vigneswara V2, Newlaczyl A2, Wayne D2, Ahmed B2, Saddington S2, Brewer C2, Raut N2, Gerdes HK2, Erdozain AM3, Tooth D4, Bolt EL4, Osna NA5, Tuma DJ5, Kharbanda KK5.
  • Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Mar 13;458(3):626-31. doi: 10.1016/j.bbrc.2015.01.158. Epub 2015 Feb 13.
  • We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl methyltransferase (PIMT), an enzyme that triggers repair of isoaspartate protein damage. To further investigate the mechanism of isoaspartate accu
  • PMID 25684186
  • Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging.
  • Qin Z1, Dimitrijevic A1, Aswad DW2.
  • Neurobiology of aging.Neurobiol Aging.2015 Feb;36(2):1029-36. doi: 10.1016/j.neurobiolaging.2014.10.036. Epub 2014 Nov 4.
  • Isoaspartate formation is a common type of protein damage normally kept in check by the repair enzyme protein-L-isoaspartyl methyltransferase (PIMT). Mice with a knockout of the gene (Pcmt1) for this enzyme (KO, -/-) exhibit a pronounced neuropathology with fatal epileptic seizures at 30-60 days. He
  • PMID 25465735
  • Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span.
  • Amer M1, Elhefnawi M, El-Ahwany E, Awad AF, Gawad NA, Zada S, Tawab FM.
  • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2014 Nov;35(11):11301-9. doi: 10.1007/s13277-014-2445-4. Epub 2014 Aug 14.
  • MicroRNAs are small 19-25 nucleotides which have been shown to play important roles in the regulation of gene expression in many organisms. Downregulation or accumulation of miRNAs implies either tumor suppression or oncogenic activation. In this study, differentially expressed hsa-miR-195 in hepato
  • PMID 25119594


  • 異性化タンパク質修復酵素PIMTの細胞機能における役割(誌上シンポジウム)
  • 古地 壯光,本間 浩
  • 藥學雜誌 127(12), 1927-1936, 2007-12-01
  • … The formation of L-isoaspartyl (or D-aspartyl) residues, through either the deamidation of asparagine or dehydration of aspartate, is one of the most frequent types of deterioration occurring under physiological conditions. … Protein L-isoaspartate/D-aspartate o-methyltransferase (PIMT) is a conserved and ubiquitous enzyme that participates in the repair of various isomerized proteins. …
  • NAID 110006546568
  • 高度好熱古細菌Sulfolobus tokodaii由来protein L-isoaspartyl-O-methyltransferaseの多量体化による耐熱性獲得機構
  • 田中 良和
  • 生物物理 46(4), 209-213, 2006-07-25
  • … Here I describe how oligomerization contributes to the thermostability in protein L-isoaspartyl-O-methyltransferase from Sulfolobus tokodaii from its crystal structural and mutational analyses. …
  • NAID 110004751710


Protein L-isoaspartyl methyltransferase regulates p53 activity Jae-Cheol Lee 1, Sung-Ung Kang 2, Yeji Jeon 1, Jong Woo Park 1, Jueng-Soo You 1, Shin-Won Ha 1, Narkhyun Bae 2, Gert Lubec 2, So Hee Kwon 3, Ju-Seog Lee ...
1. J Neurochem. 2002 Nov;83(3):581-91. Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin. Lanthier J(1), Bouthillier A, Lapointe M ...



リンク元タンパク質L-イソアスパラギン酸メチル基転移酵素」「protein D-aspartate-L-isoaspartate methyltransferase」「タンパク質L-イソアスパルチルメチルトランスフェラーゼ



protein L-isoaspartyl methyltransferase

protein D-aspartate-L-isoaspartate methyltransferase」



protein L-isoaspartyl methyltransferase



protein L-isoaspartyl methyltransferase


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WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

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「the 12th letter of the Roman alphabet」

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