protectin

関

CD59

同

CD59

関

CD59

WordNet

1. shielding (or designed to shield) against harm or discomfort; "the protecting blanket of snow"; "a protecting alibi"
2. use tariffs to favor domestic industry
3. shield from danger, injury, destruction, or damage; "Weatherbeater protects your roof from the rain"

PrepTutorEJDIC

1. (危険・損害などから)…‘を'『守る』,『保護する』《+『名』+『from』(『against』)+『名』(do『ing』)》 / 〈国内産業〉‘を'保護する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/09 23:58:37」(JST)

wiki en

[Wiki en表示]

CD59
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CDQ, 1CDR, 1CDS, 1ERG, 1ERH, 2J8B, 2OFS, 2UWR, 2UX2, 4BIK
Identifiers
Aliases	CD59, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 molecule
External IDs	OMIM: 107271 MGI: 1888996 HomoloGene: 56386 GeneCards: CD59
Gene ontology Molecular function • protein binding • complement binding Cellular component • vesicle • endoplasmic reticulum membrane • membrane • focal adhesion • Golgi membrane • plasma membrane • extracellular region • cell surface • compact myelin • anchored component of external side of plasma membrane • ER to Golgi transport vesicle membrane • anchored component of membrane • sarcolemma • extracellular exosome • endoplasmic reticulum-Golgi intermediate compartment membrane • extracellular space • specific granule membrane • tertiary granule membrane Biological process • blood coagulation • negative regulation of apoptotic process • negative regulation of activation of membrane attack complex • ER to Golgi vesicle-mediated transport • cell surface receptor signaling pathway • COPII vesicle coating • positive regulation of T cell proliferation • regulation of complement activation • cell activation • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	966	333883
Ensembl	ENSG00000085063	ENSMUSG00000068686
UniProt	P13987 Q6FHM9	P58019
RefSeq (mRNA)	NM_203331 NM_000611 NM_001127223 NM_001127225 NM_001127226 NM_001127227 NM_203329 NM_203330	NM_181858
RefSeq (protein)	NP_000602 NP_001120695 NP_001120697 NP_001120698 NP_001120699 NP_976074 NP_976075 NP_976076 NP_000602.1 NP_001120695.1 NP_001120697.1 NP_001120698.1 NP_001120699.1 NP_976074.1 NP_976075.1 NP_976076.1	NP_862906.1 NP_862906
Location (UCSC)	Chr 11: 33.7 – 33.74 Mb	Chr 2: 104.07 – 104.09 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It belongs to the LY6/uPAR/alpha-neurotoxin protein family.

CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex. It may also signal the cell to perform active measures such as endocytosis of the CD59-CD9 complex.

Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.

Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.

References

Further reading

• Tandon N, Morgan BP, Weetman AP (1992). "Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells". Immunology. 75 (2): 372–7. PMC 1384722. PMID 1372592. 
• Holmes CH, Simpson KL, Okada H, et al. (1992). "Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55)". Eur. J. Immunol. 22 (6): 1579–1585. doi:10.1002/eji.1830220635. PMID 1376264. 
• Hahn WC, Menu E, Bothwell AL, et al. (1992). "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59". Science. 256 (5065): 1805–1807. doi:10.1126/science.1377404. PMID 1377404. 
• Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9". J. Biol. Chem. 267 (19): 13675–80. PMID 1377690. 
• Petranka JG, Fleenor DE, Sykes K, et al. (1992). "Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 7876–7879. doi:10.1073/pnas.89.17.7876. PMC 49817. PMID 1381503. 
• Motoyama N, Okada N, Yamashina M, Okada H (1992). "Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene". Eur. J. Immunol. 22 (10): 2669–2673. doi:10.1002/eji.1830221029. PMID 1382994. 
• Rooney IA, Morgan BP (1992). "Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid". Immunology. 76 (4): 541–7. PMC 1421564. PMID 1383132. 
• Tone M, Walsh LA, Waldmann H (1992). "Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation". J. Mol. Biol. 227 (3): 971–976. doi:10.1016/0022-2836(92)90239-G. PMID 1383553. 
• Philbrick WM, Palfree RG, Maher SE, et al. (1990). "The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility". Eur. J. Immunol. 20 (1): 87–92. doi:10.1002/eji.1830200113. PMID 1689664. 
• Sawada R, Ohashi K, Anaguchi H, et al. (1990). "Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes". DNA Cell Biol. 9 (3): 213–220. doi:10.1089/dna.1990.9.213. PMID 1692709. 
• Yamashina M, Ueda E, Kinoshita T, et al. (1990). "Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria". N. Engl. J. Med. 323 (17): 1184–1189. doi:10.1056/NEJM199010253231707. PMID 1699124. 
• Rooney IA, Morgan BP (1991). "Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins". Immunology. 71 (3): 308–11. PMC 1384423. PMID 1702747. 
• Watts MJ, Dankert JR, Morgan EP (1990). "Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids". Biochem. J. 265 (2): 471–7. PMC 1136908. PMID 2302178. 
• Okada H, Nagami Y, Takahashi K, et al. (1989). "20 KDa homologous restriction factor of complement resembles T cell activating protein". Biochem. Biophys. Res. Commun. 162 (3): 1553–1559. doi:10.1016/0006-291X(89)90852-8. PMID 2475111. 
• Davies A, Simmons DL, Hale G, et al. (1989). "CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells". J. Exp. Med. 170 (3): 637–654. doi:10.1084/jem.170.3.637. PMC 2189447. PMID 2475570. 
• Sawada R, Ohashi K, Okano K, et al. (1989). "Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C". Nucleic Acids Res. 17 (16): 6728–6728. doi:10.1093/nar/17.16.6728. PMC 318369. PMID 2476718. 
• Sugita Y, Tobe T, Oda E, et al. (1990). "Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement". J. Biochem. 106 (4): 555–7. PMID 2606909. 
• Bora NS, Gobleman CL, Atkinson JP, et al. (1994). "Differential expression of the complement regulatory proteins in the human eye". Invest. Ophthalmol. Vis. Sci. 34 (13): 3579–84. PMID 7505007. 
• Kieffer B, Driscoll PC, Campbell ID, et al. (1994). "Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins". Biochemistry. 33 (15): 4471–4482. doi:10.1021/bi00181a006. PMID 7512825. 
• Kennedy SP, Rollins SA, Burton WV, et al. (1994). "Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59". Transplantation. 57 (10): 1494–501. doi:10.1097/00007890-199405000-00017. PMID 7515200. 

External links

• CD59 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 発作性夜間血色素尿症の病因 pathogenesis of paroxysmal nocturnal hemoglobinuria
• 2. 発作性夜間血色素尿症の臨床症状および診断 clinical manifestations and diagnosis of paroxysmal nocturnal hemoglobinuria
• 3. 補体系の制御因子および受容体 regulators and receptors of the complement system
• 4. 補体系の遺伝性疾患 inherited disorders of the complement system
• 5. 腎同種移植片のC4d染色および抗体媒介性拒絶反応の治療 c4d staining in renal allografts and treatment of antibody mediated rejection

English Journal

• Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis.

• Zhu M1,2, Wang X1,3, Hjorth E1, Colas RA4, Schroeder L1, Granholm AC5, Serhan CN4, Schultzberg M6.
• Molecular neurobiology.Mol Neurobiol.2015 Dec 9. [Epub ahead of print]
• Inflammation in the brain is a prominent feature in Alzheimer's disease (AD). Recent studies suggest that chronic inflammation can be a consequence of failure to resolve the inflammation. Resolution of inflammation is mediated by a family of lipid mediators (LMs), and the levels of these specialized
• PMID 26650044

• Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins.

• Cianci E1, Recchiuti A2, Trubiani O3, Diomede F3, Marchisio M1, Miscia S1, Colas RA4, Dalli J4, Serhan CN4, Romano M5.
• Stem cells translational medicine.Stem Cells Transl Med.2015 Nov 25. pii: sctm.2015-0163. [Epub ahead of print]
• : Unresolved inflammation and tissue destruction are underlying mechanisms of periodontitis, which is linked to dysregulated polymorphonuclear neutrophil (PMN) functions. Lipoxin A4 (LXA4) is a specialized proresolving lipid mediator (SPM) that dampens excessive inflammation, promotes resolution, an
• PMID 26607175

• Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages.

• Aursnes M1, Tungen JE1, Colas RA2, Vlasakov I2, Dalli J2, Serhan CN2, Hansen TV1.
• Journal of natural products.J Nat Prod.2015 Nov 18. [Epub ahead of print]
• The n-3 polyunsaturated fatty acids act as substrates during the resolution phase of acute inflammation for the biosynthesis of specialized pro-resolving lipid mediators. One premier example is the C22-dihydroxy-polyunsaturated fatty acid protectin D1 (1). The human 15-lipoxygenase type I, via stere
• PMID 26580578

Japanese Journal

• Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases

• Miyata Jun,Arita Makoto
• Allergology International 64(1), 27-34, 2015
• Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in …
• NAID 130004873127

• アレルギーの発症と抗炎症性脂質メディエーター (特集 アレルギーの発症への関与因子)

• 福永 興壱
• 臨床免疫・アレルギー科 61(1), 33-38, 2014-01
• NAID 40019955133

• D-10-4 ESD入力保護能力を低下させないIC間断線の電気的検査用回路(D-10.ディペンダブルコンピューテイング,一般セッション)

• 小西 朝陽,四柳 浩之,橋爪 正樹
• 電子情報通信学会総合大会講演論文集 2012年_情報・システム(1), 179, 2012-03-06
• NAID 110009461352

Related Links

• カーセキュリティー専門店 プロテクション PROTECTION

大阪の門真市にあるカーセキュリティ専門店PROTECTION、持ち込み取付もOK。まずはお気軽にご相談ください。 ... 電話番号 072-885-6123 店舗の場所はコチラです ※国産車のナビゲーションやHIDやLEDやキーレスエントリーや

• ウイルス対策ソフトウェア | シマンテック

Symantec Endpoint Protection は最高レベルのウイルス対策保護を実現します。仮想でも物理でも最強クラスのエンドポイントウイルス対策ソフトウェアについてご紹介します。 ... ネットワーク脅威防止機能は受信するデータストリームを分析 ...

Related Pictures

---

★リンクテーブル★

リンク元	「CD59」
拡張検索	「protecting color」
関連記事	「protect」

「CD59」

　　[★]

同

protectin

-HRF

同

homologous restriction factor

同

Complement protein; Membrane inhib- itor reactive lysis; Homologous restriction factor 20

同

protectin

「protecting color」

　　[★]

• 保護色

関

concealing coloration、crypsis、cryptic color、protective coloration

「protect」

　　[★]

• 保護する

関

conservation、conserve、guardian、protection、safeguard