prostanoids

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/08/03 21:37:12」(JST)

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英文文献

  • Evidence that PGE2 in the dorsal and median raphe nuclei is involved in LPS-induced anorexia in rats.
  • Kopf BS, Langhans W, Geary N, Hrupka B, Asarian L.AbstractAnorexia is an element of the acute-phase immune response. Its mechanisms remain poorly understood. Activation of inducible cyclooxygenase-2 (COX-2) in blood-brain-barrier endothelial cells and subsequent release of prostaglandins (e.g., prostaglandin E2, PGE2) may be involved. Therefore, we sought to relate the effects of prostaglandins on the anorexia following gram-negative bacterial lipopolysaccharide treatment (LPS) to neural activity in the dorsal and median raphe nuclei (DRN and MnR) in rats. COX-2 antagonist (NS-398, 10mg/kg; IP) administration prior to LPS (100μg/kg; IP) prevented anorexia and reduced c-Fos expression the DRN, MnR, nucleus tractus solitarii and several related forebrain areas. These data indicate that COX-2-mediated prostaglandin synthesis is necessary for LPS anorexia and much of the initial LPS-induced neural activation. Injection of NS-398 into the DRN and MnR (1ng/site) attenuated LPS-induced anorexia to nearly the same extent as IP NS-398, suggesting that prostaglandin signaling in these areas is necessary for LPS anorexia. Because the DRN and MnR are sources of major serotonergic projections to the forebrain, these data suggest that serotonergic neurons originating in the midbrain raphe play an important role in acute-phase response anorexia.
  • Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2011 Sep;99(3):437-43. Epub 2011 Apr 17.
  • Anorexia is an element of the acute-phase immune response. Its mechanisms remain poorly understood. Activation of inducible cyclooxygenase-2 (COX-2) in blood-brain-barrier endothelial cells and subsequent release of prostaglandins (e.g., prostaglandin E2, PGE2) may be involved. Therefore, we sought
  • PMID 21527272
  • A profile of NSAID-targeted arachidonic acid metabolisms in human embryonic stem cells (hESCs): Implication of the negative effects of NSAIDs on heart tissue regeneration.
  • Chillar A, So SP, Ruan CH, Shelat H, Geng YJ, Ruan KH.SourceCenter for Experimental Therapeutics and Pharmacoinformatics, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, United States.
  • International journal of cardiology.Int J Cardiol.2011 Aug 4;150(3):253-9. Epub 2010 May 7.
  • INTRODUCTION: An emerging technology using human embryonic stem cells (hESCs) to regenerate infarcted heart tissue has been underdeveloped. However, because non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are taken during the infarction, it becomes critical to know whether the NSAID
  • PMID 20451268

和文文献

  • Prostanoids in allergy
  • Honda Tetsuya,Kabashima Kenji
  • Allergology International 64(1), 11-16, 2015
  • Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released in various pathophysiological conditions. … Here, we review the recent findings on the roles of prostanoids in allergy, especially focusing on atopic dermatitis and asthma. …
  • NAID 130004873121
  • Roles of Prostanoids in Regulation of Angiogenesis and Lymphatic Tissue Remodeling
  • Majima Masataka
  • Microvascular Reviews and Communications 7(1), 31-31, 2014
  • Inflammation influences the pathogenesis of cancers by induction of genome damage, proliferation in stromal cells, and generation of inflammatory mediators. Angiogenesis is also a critical step for de …
  • NAID 130004678469
  • Roles of eicosanoids in pulmonary fibrosis
  • Oga Toru,Handa Tomohiro,Mishima Michiaki,Chin Kazuo,Narumiya Shuh
  • Inflammation and Regeneration 33(2), 109-113, 2013
  • … Mice lacking cytosolic phospholipase A<SUB>2</SUB>, a key enzyme triggering the production of arachidonic acid metabolites such as eicosanoids including prostanoids and leukotrienes, did not develop bleomycin-induced pulmonary fibrosis, indicating that arachidonic acid metabolites play an important role in the pathogenesis of pulmonary fibrosis. …
  • NAID 130004943838

関連リンク

PROSTANOIDS AND RELATED COMPOUNDS A large number of fatty acid derivatives often present in tiny concentrations were discovered to have profound effects on cellular physiological or pathophysiological reactions. Because of ...
Cyclooxygenase (COX) catalyzes the conversion of the free essential fatty acids to prostanoids by a two-step process. In the first step, two molecules of O 2 are added as two peroxide linkages and a 5-member carbon ring is forged ...

関連画像

Prostanoidsactive prostanoids such as pgd2 pge2 Arachidonic Acid and the Prostanoids: Our Biosynthesis of prostanoids PPT Slide acid to biologically active prostanoidsPROSTANOIDS - PROSTAGLANDINS


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