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a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/16 21:14:02」(JST)

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An eicosanoid receptor is an integral membrane protein that detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.^[1]

The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:^[2]^[3]

Leukotriene

Leukotrienes:

BLT₁ (Leukotriene B₄ receptor) - LTB4R
BLT₂ (Leukotriene B₄ receptor 2) - LTB4R2
CysLT₁ (Cysteinyl leukotriene receptor 1) - CYSLTR1
CysLT₂ (Cysteinyl leukotriene receptor 2) - CYSLTR2

Lipoxin

Lipoxins:

LXA4R (Formyl peptide receptor-like 1) - FPRL1

Oxoeicosanoid

Oxoeicosanoid:^[4]

Oxoeicosanoid (OXE) receptor 1 - OXER1

Prostanoid

Prostanoids:

PGD₂: DP-(PGD₂)
- DP₁ (Prostaglandin D2 receptor) - PTGDR
- DP₂ (GPR44) - GPR44
PGE₂:
- EP₁-(PGE₂) (PTGER1) - PTGER1
- EP₂-(PGE₂) (PTGER2) - PTGER2
- EP₃-(PGE₂) (PTGER3) - PTGER3
- EP₄-(PGE₂) (PTGER4) - PTGER4
PGF_2α: FP-(PGF_2α) (PTGFR) - PTGFR
PGI₂ (prostacyclin): IP-(PGI₂) (PTGIR) - PTGIR
TXA₂ (thromboxane): TP-(TXA₂) (TBXA2R) - TBXA2R

References

^ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). "The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers". Carcinogenesis 19 (1): 49–53. doi:10.1093/carcin/19.1.49. PMID 9472692.
^ Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). "International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors". Pharmacol. Rev. 55 (1): 195–227. doi:10.1124/pr.55.1.8. PMID 12615958.
^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665.

External links

"Leukotriene Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
"Prostanoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Eicosanoid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Regulated expression of the prostacyclin receptor (IP) gene by androgens within the vasculature: Combined role for androgens and serum cholesterol.

Eivers SB1, Kinsella BT2.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Oct;1859(10):1333-51. doi: 10.1016/j.bbagrm.2016.06.011. Epub 2016 Jun 27.
The prostanoid prostacyclin plays a key cardioprotective role within the vasculature. There is increasing evidence that androgens may also confer cardioprotection but through unknown mechanisms. This study investigated whether the androgen dihydrotestosterone (DHT) may regulate expression of the pro
PMID 27365208

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations.

Mortimer L1, Moreau F1, MacDonald JA2, Chadee K1.
Nature immunology.Nat Immunol.2016 Oct;17(10):1176-86. doi: 10.1038/ni.3538. Epub 2016 Aug 22.
Inflammasomes are positioned to rapidly escalate the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. However, negative regulation of inflammasomes remains poorly understood, as is the signaling cascade that dampens inflammasome activity. We found tha
PMID 27548431

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.

Schneider G1, Reker D2, Chen T2, Hauenstein K2, Schneider P2,3, Altmann KH2.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2016 Sep 26;55(40):12408-11. doi: 10.1002/anie.201605707. Epub 2016 Sep 8.
The cyclodepsipeptide doliculide is a marine natural product with strong actin-polymerizing and anticancer activities. Evidence for doliculide acting as a potent and subtype-selective antagonist of prostanoid E receptor 3 (EP3) is presented. Computational target prediction suggested that this memb
PMID 27605391

Japanese Journal

ダイオキシン毒性とその分子標的の解明

遠山千春
日本衛生学雑誌 69(1), 1-7, 2014
… Dioxin toxicity, which has raised a significant concern in society, was discovered to be mediated by a high-affinity receptor, aryl hydrocarbon receptor (AhR), more than three decades ago. … This receptor has been established to be essential for the manifestation of various toxicities, such as carcinogenicity, reproductive toxicity, developmental neurotoxicity, and immunotoxicity. …
NAID 130003394509

Pharmacological Evidence Showing Significant Roles for Potassium Channels and CYP Epoxygenase Metabolites in the Relaxant Effects of Docosahexaenoic Acid on the Rat Aorta Contracted with U46619

Sato Kyosuke,Chino Daisuke,Nishioka Nanako,Kanai Keisuke,Aoki Mika,Obara Keisuke,Miyauchi Seiji,Tanaka Yoshio
Biological and Pharmaceutical Bulletin 37(3), 394-403, 2014
… Docosahexaenoic acid (DHA) shows more pronounced relaxation when blood vessel is contracted with prostanoid receptor agonists than other stimulants. … The present study was carried out to obtain information on the mechanisms underlying prostanoid receptor-selective relaxant action of DHA, particularly focusing on the possible roles for K+ channels and its CYP epoxygenase (EOX) metabolites. …
NAID 130003382129

Prostaglandin E receptor subtype EP4 agonist serves better to protect cochlea than prostaglandin E1.

Hori Ryusuke,Nakagawa Takayuki,Yamamoto Norio,Hamaguchi Kiyomi,Ito Juichi
Auris nasus larynx 40(6), 539-542, 2013-12
… [Objective]The present study aimed to examine whether an E-prostanoid receptor 4 (EP4) agonist has superior protective effects to those of prostaglandin E1 (PGE1) in a guinea pig model of noise trauma. …
NAID 120005323027