proscillaridin

プロスシラリジン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/13 14:37:08」(JST)

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Proscillaridin

Systematic (IUPAC) name
5-[(3S,8R,9S,10R,13R,14S,17R)- 14-hydroxy- 10,13-dimethyl- 3-((2R,3R,4R,5R,6R)- 3,4,5-trihydroxy- 6-methyltetrahydro- 2H-pyran-2-yloxy)- 2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- 1H-cyclopenta[a]phenanthren- 17-yl]- 2H-pyran- 2-one OR 3β-Rhamnosido- 14β-hydroxybufa- 4,20,22-trienolide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	466-06-8 N
ATC code	C01AB01
PubChem	CID 5284613
ChemSpider	4447658 Y
UNII	KC6BL281EN Y
ChEMBL	CHEMBL600325 Y
Chemical data
Formula	C30H42O8
Mol. mass	530.650
SMILES O=C\1O\C=C(/C=C/1)[C@H]2CC[C@@]6(O)[C@]2(C)CC[C@H]5[C@H]6CC/C4=C/[C@@H](O[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)CC[C@@]45C
InChI InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1 Y Key:MYEJFUXQJGHEQK-ALRJYLEOSA-N Y
N (what is this?)  (verify)

Proscillaridin is a cardiac glycoside, a kind of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is of the bufanolide type and can be obtained from plants of the genus Scilla, notably Scilla maritima.

References

English Journal

• Inhibition of DNA topoisomerases I and II by G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in a cell free system.

• Winnicka K, Bielawska A, Bielawski K.SourceDepartment of Pharmaceutical Technology, Medical University of Białystok, Kilińskiego 1, 15-089 Białystok, Poland. kwin@umwb.edu.pl
• Acta poloniae pharmaceutica.Acta Pol Pharm.2010 Nov-Dec;67(6):630-4.
• Two modified glycosides--digoxin and proscillaridin A conjugated to a generation 3 of polyamidoamine dendrimer (G3 PAMAM-NH2) were evaluated as DNA topoisomerase II inhibitors. The ability of these compounds (PAMAM-Dig and PAMAM-Prosc) to inhibit topoisomerase I and II activity was quantified by mea
• PMID 21229879

• Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.

• Winnicka K, Bielawski K, Bielawska A.SourceDepartment of Pharmaceutical Technology, Medical University of Białystok, Kilińskiego 1, PL 15-089 Białystok, Poland. kwin@umwb.edu.pl
• Pharmacological reports : PR.Pharmacol Rep.2010 Mar-Apr;62(2):414-23.
• The objective of this study was to determine the cytotoxicity, antiproliferative activity, and apoptosis induction activity of two modified glycosides - digoxin and proscillaridin A - conjugated to a generation 3 polyamidoamine dendrimer (G3 PAMAM-NH(2)) in human breast cancer cells. The results sug
• PMID 20508299

Japanese Journal

• Antiproliferative Activity of Derivatives of Ouabain, Digoxin and Proscillaridin A in Human MCF-7 and MDA-MB-231 Breast Cancer Cells(Pharmacology)

• Biological & pharmaceutical bulletin 31(6), 1131-1140, 2008-06-01
• NAID 110006684329

• Inhibition of DNA Topoisomerases I and II, and Growth Inhibition of Breast Cancer MCF-7 Cells by Ouabain, Digoxin and Proscillaridin A(Pharmacology)

• Biological & pharmaceutical bulletin 29(7), 1493-1497, 2006-07-01
• NAID 110005602330

• 薬剤による高度な徐脈を誘因として右心不全が増悪した高齢者特発性右房拡張症の１例

• 日本老年医学会雑誌 38(4), 544-547, 2001
• NAID 130003444507

Related Links

• Proscillaridin | Online references | cyclopaedia.net

References for "Proscillaridin" online, at universities and in literature... cyclopaedia.net ... Many medications have been developed for one purpose but then are found to have other clinical activities. There is tremendous interest in ...

• Proscillaridin A | CAS 466-06-8 | Santa Cruz Biotech

Buy Proscillaridin A (CAS 466-06-8), a cardiac glycoside and sodium/potassium ATPase inhibitor, from Santa Cruz. Purity ≥90%, MF C30H42O8, MW 530.66 ... Synonym: 3-(6-Deoxy-α-L-mannopyranosyloxyl)-14-hydroxybufa-4,20 ...

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