関: proparacaine hydrochloride、proxymetacaine

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/16 10:54:28」(JST)

wiki en

Proxymetacaine (INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester group.

Clinical pharmacology[edit]

Indications and usage[edit]

Proxymetacaine hydrochloride ophthalmic solution (eye drops) is indicated for procedures such as tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva.

Warnings[edit]

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss.

Mechanism of action[edit]

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.

How supplied[edit]

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 結膜損傷 conjunctival injury
2. 細隙灯検査 slit lamp examination
3. 角膜剥離および角膜異物 corneal abrasions and corneal foreign bodies
4. 局所麻酔剤に対するアレルギー反応 allergic reactions to local anesthetics
5. 局所化学熱傷 topical chemical burns

English Journal

Comparison of Central Corneal Thickness Measurements Obtained by RTVue OCT, Lenstar, Sirius Topography, and Ultrasound Pachymetry in Healthy Subjects.

Şimşek A1, Bilak Ş, Güler M, Çapkin M, Bilgin B, Reyhan AH.
Seminars in ophthalmology.Semin Ophthalmol.2015 Aug 21:1-6. [Epub ahead of print]
PURPOSE: To compare central corneal thickness (CCT) measurement results obtained by RTVue OCT, Lenstar, Sirius topography, and ultrasound pachymetry (UP) (OcuScan RxP Ophthalmic Ultrasound System, Alcon Laboratories) in healthy subjects.MATERIALS AND METHODS: 256 eyes of 128 healthy subjects were in
PMID 25412328

The Safety of Topical Anesthetics in the Treatment of Corneal Abrasions: A Review.

Swaminathan A1, Otterness K1, Milne K2, Rezaie S3.
The Journal of emergency medicine.J Emerg Med.2015 Aug 14. pii: S0736-4679(15)00692-7. doi: 10.1016/j.jemermed.2015.06.069. [Epub ahead of print]
BACKGROUND: Despite the fact that topical anesthetics provide superb analgesia to the painful eye, they are not prescribed routinely to patients when they are discharged from the emergency department because of concerns for delayed healing and corneal erosion.OBJECTIVE: To summarize the evidence for
PMID 26281814

Effect of cooling proparacaine 0.5% eye drops on patient's comfort during instillation.

Hu Youwei J1, Chang B1.
Eye (London, England).Eye (Lond).2015 Aug;29(8):1112-3. doi: 10.1038/eye.2015.59. Epub 2015 Apr 24.
PMID 25907208

Japanese Journal

Cytotoxicity of proparacaine to human corneal endothelial cells <i>in vitro </i>

The Journal of Toxicological Sciences 40(4), 427-436, 2015
NAID 130005087448

Effect of proparacaine on tropicamide-induced mydriasis

Optom Vis Sci 74, 1039-1043, 1997
NAID 30009496483

Related Pictures

★リンクテーブル★

リンク元	「プロパラカイン」「proxymetacaine」
拡張検索	「proparacaine hydrochloride」

「プロパラカイン」

Proxymetacaine
Systematic (IUPAC) name
	2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C (US)
Legal status	?
Routes	Topical (eye drops)
Pharmacokinetic data
Metabolism	Plasma
Identifiers
CAS number	499-67-2; 5875-06-9 (HCl)
ATC code	S01HA04
PubChem	CID 4935
DrugBank	DB00807
ChemSpider	4766
UNII	B4OB0JHI1X
KEGG	D08448
ChEMBL	CHEMBL1196
Chemical data
Formula	C16H26N2O3
Mol. mass	294.389 g/mol
	SMILES O=C(OCCN(CC)CC)c1ccc(OCCC)c(c1)N;
	InChI InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3 ; Key:KCLANYCVBBTKTO-UHFFFAOYSA-N ;
(what is this?) (verify)