promazine

出典: meddic

プロマジン

bromazine

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/15 17:24:12」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/07/05 22:11:35」(JST)

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英文文献

  • Field-amplified sample injection coupled with pseudo-isotachophoresis technique for sensitive determination of selected psychiatric drugs in human urine samples after dispersive liquid-liquid microextraction.
  • Dziomba S1, Kowalski P2, Słomińska A1, Bączek T1.Author information 1Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland.2Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland. Electronic address: piotr.kowalski@gumed.edu.pl.AbstractA field-amplified sample injection (FASI) technique was elaborated for fast and sensitive determination of selected central nervous system drugs in human urine samples. Factors affecting the sensitivity enhancement, such as background electrolyte (BGE) and the analytical matrix composition were optimized and discussed. Pseudo-isotachophoresis (p-ITP) mechanism contribution in preconcentration mechanism was discussed. All separations were performed in uncoated fused silica capillaries 50 μm × 57 cm at 22 kV. The optimized analytical matrix was composed of 0.25 mM HCOOH in 90% (v/v) methanol, while BGE contained 45 mM TRIS/HCl (pH 2.20). The head-column injection was performed in 0.25 mM HCOOH water solution (3s, 3.45 kPa). Sample was introduced into the capillary by electrokinetic injection (70 s, 5 kV) followed by short BGE plug (3s, 3.45 kPa). Seven psychiatric drugs (olanzapine, prochlorperazine dimaleate, trifluoperazine dihydrochloride, perphenazine, promazine hydrochloride, clomipramine hydrochloride, and chlorprothixene hydrochloride) were separated in about 6 min. The elaborated method was additionally supported with dispersive liquid-liquid microextraction (DLLME) technique which in summary with FASI provided about 8000-13,000-fold sensitivity enhancement in comparison to the capillary zone electrophoresis (CZE) method with standard hydrodynamic injection (5s, 3.45 kPa).
  • Analytica chimica acta.Anal Chim Acta.2014 Feb 6;811:88-93. doi: 10.1016/j.aca.2013.12.021. Epub 2013 Dec 26.
  • A field-amplified sample injection (FASI) technique was elaborated for fast and sensitive determination of selected central nervous system drugs in human urine samples. Factors affecting the sensitivity enhancement, such as background electrolyte (BGE) and the analytical matrix composition were opti
  • PMID 24456599
  • Structural basis of prion inhibition by phenothiazine compounds.
  • Baral PK1, Swayampakula M1, Rout MK1, Kav NN2, Spyracopoulos L1, Aguzzi A3, James MN4.Author information 1Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.2Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.3Department of Pathology, Institute of Neuropathology, University Hospital Zurich, Zurich 8091, Switzerland.4Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address: michael.james@ualberta.ca.AbstractConformational transitions of the cellular form of the prion protein, PrP(C), into an infectious isoform, PrP(Sc), are considered to be central events in the progression of fatal neurodegenerative diseases known as transmissible spongiform encephalopathies. Tricyclic phenothiazine compounds exhibit antiprion activity; however, the underlying molecular mechanism of PrP(Sc) inhibition remains elusive. We report the molecular structures of two phenothiazine compounds, promazine and chlorpromazine bound to a binding pocket formed at the intersection of the structured and the unstructured domains of the mouse prion protein. Promazine binding induces structural rearrangement of the unstructured region proximal to β1, through the formation of a "hydrophobic anchor." We demonstrate that these molecules, promazine in particular, allosterically stabilize the misfolding initiator-motifs such as the C terminus of α2, the α2-α3 loop, as well as the polymorphic β2-α2 loop. Hence, the stabilization effects of the phenothiazine derivatives on initiator-motifs induce a PrP(C) isoform that potentially resists oligomerization.
  • Structure (London, England : 1993).Structure.2014 Feb 4;22(2):291-303. doi: 10.1016/j.str.2013.11.009. Epub 2013 Dec 26.
  • Conformational transitions of the cellular form of the prion protein, PrP(C), into an infectious isoform, PrP(Sc), are considered to be central events in the progression of fatal neurodegenerative diseases known as transmissible spongiform encephalopathies. Tricyclic phenothiazine compounds exhibit
  • PMID 24373770
  • Quantification of typical antipsychotics in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring.
  • Gradinaru J1, Vullioud A, Eap CB, Ansermot N.Author information 1Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, 1008 Prilly-Lausanne, Switzerland.AbstractA selective and sensitive method was developed for the simultaneous quantification of seven typical antipsychotic drugs (cis-chlorprothixene, flupentixol, haloperidol, levomepromazine, pipamperone, promazine and zuclopenthixol) in human plasma. Ultra-high performance liquid chromatography (UHPLC) was used for complete separation of the compounds in less than 4.5min on an Acquity UPLC BEH C18 column (2.1mm×50mm; 1.7μm), with a gradient elution of ammonium formate buffer pH 4.0 and acetonitrile at a flow rate of 400μl/min. Detection was performed on a tandem quadrupole mass spectrometer (MS/MS) equipped with an electrospray ionization interface. A simple protein precipitation procedure with acetonitrile was used for sample preparation. Thanks to the use of stable isotope-labeled internal standards for all analytes, internal standard-normalized matrix effects were in the range of 92-108%. The method was fully validated to cover large concentration ranges of 0.2-90ng/ml for haloperidol, 0.5-90ng/ml for flupentixol, 1-450ng/ml for levomepromazine, promazine and zuclopenthixol and 2-900ng/ml for cis-chlorprothixene and pipamperone. Trueness (89.1-114.8%), repeatability (1.8-9.9%), intermediate precision (1.9-16.3%) and accuracy profiles (<30%) were in accordance with the latest international recommendations. The method was successfully used in our laboratory for routine quantification of more than 500 patient plasma samples for therapeutic drug monitoring. To the best of our knowledge, this is the first UHPLC-MS/MS method for the quantification of the studied drugs with a sample preparation based on protein precipitation.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2014 Jan 25;88:36-44. doi: 10.1016/j.jpba.2013.07.041. Epub 2013 Aug 7.
  • A selective and sensitive method was developed for the simultaneous quantification of seven typical antipsychotic drugs (cis-chlorprothixene, flupentixol, haloperidol, levomepromazine, pipamperone, promazine and zuclopenthixol) in human plasma. Ultra-high performance liquid chromatography (UHPLC) wa
  • PMID 24036032

和文文献

  • 犬の麻酔前投薬-導入薬の組み合わせとしてのプロピオニールプロマジン-プロポフォール, -ケタミン, または-チオペンタールの効果
  • 山下 和人,伊藤 若菜,久代 季子,UMAR Mohammed Ahmed,都築 圭子,前原 誠也,瀬野 貴弘,泉澤 康晴
  • 日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 57(10), 651-656, 2004-10-20
  • NAID 10013655246
  • Thermodynamics of Partitioning of Phenothiazine Drugs between Phosphatidylcholine Bilayer Vesicles and Water Studied by Second-Derivative Spectrophotometry
  • TAKEGAMI Shigehiko,KITAMURA Keisuke,KITADE Tatsuya,KITAGAWA Ai,KAWAMURA Kikuko
  • Chemical & pharmaceutical bulletin 51(9), 1056-1059, 2003-09-01
  • … The partition coefficients (K_ps) of phenothiazine drugs (trifluoperazine, triflupromazine, chlorpromazine and promazine) between phosphatidylcholine (PC) small unilamellar vesicles (SUV) and water were determined over the temperature range of 10-40℃ by a second-derivative spectrophotometric method. …
  • NAID 110003615455

関連リンク

Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Promazine's antipsychotic effect is due to ...
promazine / ˈproʊ məˌzin / Show Spelled [proh-m uh-zeen] Show IPA noun Pharmacology. a compound, C 17 H 20 N 2 S, used as a tranquilizer. Origin: 1955–60; pro(pyl) + m(ethyl) + (thi)azine, components of its chemical name

関連画像

Promazine I P1957 Wyeth Sparine (promazine)Promazine, 10-(3-dimethylaminopropyl PromazinePromazine3d.png1959PROZINE (meprobamate and promazine


★リンクテーブル★
リンク元プロマジン」「bromazine
拡張検索chlorpromazine」「chlorpromazine phenolphthalinate」「chlorpromazine hibenzate」「chlorpromazine hydrochloride」「triflupromazine

プロマジン」

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promazine
ブロマジン


bromazine」

  [★]

ブロマジン

promazine


chlorpromazine」

  [★] クロルプロマジン

WordNet   license wordnet

「a drug (trade name Thorazine) derived from phenothiazine that has antipsychotic effects and is used as a sedative and tranquilizer」
Thorazine


chlorpromazine phenolphthalinate」

  [★]

chlorpromazinechlorpromazine hibenzatechlorpromazine hydrochloride


chlorpromazine hibenzate」

  [★]

chlorpromazinechlorpromazine hydrochloridechlorpromazine phenolphthalinate


chlorpromazine hydrochloride」

  [★]

chlorpromazinechlorpromazine hibenzatechlorpromazine phenolphthalinate


triflupromazine」

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トリフルプロマジン

triflupromazine hydrochloride




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