WordNet

lengthen or extend in duration or space; "We sustained the diplomatic negotiations as long as possible"; "prolong the treatment of the patient"; "keep up the good work" (同)sustain, keep_up
lengthen in time; cause to be or last longer; "We prolonged our stay"; "She extended her visit by another day"; "The meeting was drawn out until midnight" (同)protract, extend, draw_out
a rope fitted with a hook and used for towing a gun carriage
transient cessation of respiration

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Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene.

Wichmann S1, Færk G, Bundgaard JR, Gätke MR.
Pharmacogenetics and genomics.Pharmacogenet Genomics.2016 Jul;26(7):351-6. doi: 10.1097/FPC.0000000000000221.
INTRODUCTION: Mutations in the butyrylcholinesterase enzyme (BChE) can result in prolonged duration of action of the neuromuscular blocking agents, succinylcholine and mivacurium, as BChE hydrolyses these drugs. Hereditary low BChE activity can cause extensively prolonged apnoea during general anaes
PMID 27031121

Cerebral oxidative metabolism is decreased with extreme apnea in humans; impact of hypercapnia.

Bain AR1, Ainslie PN1, Hoiland RL1, Barak OF2,3, Cavar M2, Drvis I4, Stembridge M5, MacLeod DM6, Bailey DM7, Dujic Z2, MacLeod DB8.
The Journal of physiology.J Physiol.2016 Jun 3. doi: 10.1113/JP272404. [Epub ahead of print]
Prolonged apnea in humans is reflected in progressive hypoxemia and hypercapnia. Here, we explore the cerebral metabolic responses under extreme hypoxia and hypercapnia associated with prolonged apnea. We hypothesized that the cerebral metabolic rate for oxygen (CMRO2 ) will be reduced near the term
PMID 27256521

Delacour H1, Dedome E1, Courcelle S1, Hary B1, Ceppa F1.
Annales de biologie clinique.Ann Biol Clin (Paris).2016 Jun 1;74(3):279-285.
Butyrylcholinesterase (EC 3.1.1.8; BChE) is a sister enzyme of acetylcholinesterase. Though BChE lacks obvious physiological functions, it is of toxicological and pharmacological importance in detoxifying or catabolising ester-containing drugs. Furthermore, individuals deficient in BChE appear asymp
PMID 27237801