WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
gonadotropic hormone secreted by the anterior pituitary; in females it stimulates growth of the mammary glands and lactation after parturition (同)lactogenic_hormone, luteotropin

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/06 20:34:40」(JST)

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The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.

Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.

The receptor is a cytokine receptor,^[1] and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway,^[2]^[3] Ras-Raf-MAPK, and PI-3K.^[4]

There may be variation among different tissue prolactin receptors.^[5]

References

^ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
^ Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
^ Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
^ The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
^ Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.

External links

Prolactin receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. 高プロラクチン血症の臨床症状および診断 clinical manifestations and diagnosis of hyperprolactinemia
2. 乳汁分泌の生理学 physiology of lactation
3. 乳腺刺激腺腫およびその他の原因による高プロラクチン血症の治療 treatment of hyperprolactinemia due to lactotroph adenoma and other causes
4. 高プロラクチン血症の原因 causes of hyperprolactinemia
5. 妊娠に対する母体の内分泌系および代謝の適応 maternal endocrine and metabolic adaptation to pregnancy

English Journal

Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort.

Tikk K1, Sookthai D1, Johnson T1, Rinaldi S2, Romieu I2, Tjønneland A3, Olsen A3, Overvad K4, Clavel-Chapelon F5, Baglietto L6, Boeing H7, Trichopoulou A8, Lagiou P9, Trichopoulos D10, Palli D11, Pala V12, Tumino R13, Rosso S14, Panico S15, Agudo A16, Menéndez V17, Sánchez MJ18, Amiano P19, Huerta Castaño JM20, Ardanaz E21, Bueno-de-Mesquita HB22, Monninkhof E23, Onland-Moret C23, Andersson A24, Sund M25, Weiderpass E26, Khaw KT27, Key TJ28, Travis RC28, Gunter MJ29, Riboli E29, Dossus L5, Kaaks R30.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO.Ann Oncol.2014 Jul;25(7):1422-8. doi: 10.1093/annonc/mdu150. Epub 2014 Apr 8.
BACKGROUND: Experimental and epidemiological evidence suggests that prolactin might play a role in the etiology of breast cancer. We analyzed the relationship of prediagnostic circulating prolactin levels with the risk of breast cancer by menopausal status, use of postmenopausal hormone replacement
PMID 24718887

Impact of subdomain D1 of the short form S1b of the human prolactin receptor on its inhibitory action on the function of the long form of the receptor induced by prolactin.

Kang JH1, Hassan SA2, Zhao P1, Tsai-Morris CH1, Dufau ML3.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jul;1840(7):2272-80. doi: 10.1016/j.bbagen.2014.04.006. Epub 2014 Apr 13.
BACKGROUND: Long-form (LF) homodimers of the human prolactin receptor (PRLR) mediate prolactin's diverse actions. Short form S1b inhibits the LF function through heterodimerization. Reduced S1b/LF-ratio in breast cancer could contribute to tumor development/progression. Current work defines the stru
PMID 24735798

Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?

Ramot Y1, Paus R.
BioEssays : news and reviews in molecular, cellular and developmental biology.Bioessays.2014 Jul;36(7):672-86. doi: 10.1002/bies.201400006. Epub 2014 May 13.
Human skin produces numerous neurohormones and neuropeptides. Recent evidence has shown that the neuroendocrine regulation of human skin biology also extends to keratins, the major structural components of epithelial cells. For example, thyrotropin-releasing hormone, thyrotropin, opioids, prolactin,
PMID 24823963

Japanese Journal

Macrophage Colony-Stimulating Factor Induces Prolactin Expression in Rat Pituitary Gland

Hoshino Satoya,Kurotani Reiko,Miyano Yuki [他]
Zoological science 31(6), 390-397, 2014-06
NAID 40020091069

Relationship between the Production Traits and three Candidate Genes in the Prolactin's In/Del×In/Del Population of Silkie Fowl

Rahman Mijanur,Matsuda Riho,Matsuda Tomoe [他]
Journal of poultry science 51(2), 138-143, 2014-04
NAID 40020045284

魚類の黄色素胞ならびに赤色素胞におけるプロラクチン(PRL)誘起の色素顆粒拡散はPRL受容体-a/Jak2/Ras/cAMP/PKA経路を介して起こる

矢野雄大,西口慶一,吉岡亨 [他]
醫學と生物學 : 速報學術雜誌 157(2), 229-238, 2013-02
NAID 40019585808

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★リンクテーブル★

リンク元	「PRL receptor」「プロラクチンレセプター」
関連記事	「prolactin」

「PRL receptor」

prolactin receptor
Identifiers
Symbol	PRLR
Entrez	5618
HUGO	9446
OMIM	176761
PDB	1RW5 (RCSB PDB PDBe PDBj)
RefSeq	NM_000949
UniProt	P16471
Other data
Locus	Chr. 5 p13-p12