原核生物・訳開始因子2

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the act of starting something for the first time; introducing something new; "she looked forward to her initiation as an adult"; "the foundation of a new scientific society" (同)founding, foundation, institution, origination, creation, innovation, introduction, instauration
a formal entry into an organization or position or office; "his initiation into the club"; "he was ordered to report for induction into the army"; "he gave a speech as part of his installation into the hall of fame" (同)induction, installation
having cells that lack membrane-bound nuclei (同)procaryotic

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
〈U〉開始;創業 / 〈U〉入会,入門;〈C〉入会(入門)式 / 〈U〉手ほどき,伝授

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/21 21:07:57」(JST)

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Prokaryotic initiation factor-2 is a prokaryotic initiation factor.^[1]

IF2 binds to an initiator tRNA and controls the entry of that tRNA into the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNA_f binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and P_i, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S subunit to form.

References

^ Prokaryotic Initiation Factor-2 at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Mechanism of protein biosynthesis in mammalian mitochondria.

Christian BE, Spremulli LL.SourceDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Biochimica et biophysica acta.Biochim Biophys Acta.2012 Sep-Oct;1819(9-10):1035-54. doi: 10.1016/j.bbagrm.2011.11.009. Epub 2011 Dec 7.
Protein synthesis in mammalian mitochondria produces 13 proteins that are essential subunits of the oxidative phosphorylation complexes. This review provides a detailed outline of each phase of mitochondrial translation including initiation, elongation, termination, and ribosome recycling. The roles
PMID 22172991

Translation initiation without IF2-dependent GTP hydrolysis.

Fabbretti A, Brandi L, Milón P, Spurio R, Pon CL, Gualerzi CO.SourceLaboratory of Genetics, Department of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Macerata, Italy.
Nucleic acids research.Nucleic Acids Res.2012 Sep;40(16):7946-55. doi: 10.1093/nar/gks569. Epub 2012 Jun 20.
Translation initiation factor IF2 is a guanine nucleotide-binding protein. The free energy change associated with guanosine triphosphate hydrolase (GTPase) activity of these proteins is believed to be the driving force allowing them to perform their functions as molecular switches. We examined role
PMID 22723375

Heterogeneous pathways and timing of factor departure during translation initiation.

Tsai A, Petrov A, Marshall RA, Korlach J, Uemura S, Puglisi JD.SourceDepartment of Structural Biology, Stanford University School of Medicine, Stanford, California 94305-5126, USA.
Nature.Nature.2012 Jul 19;487(7407):390-3. doi: 10.1038/nature11172.
The initiation of translation establishes the reading frame for protein synthesis and is a key point of regulation. Initiation involves factor-driven assembly at a start codon of a messenger RNA of an elongation-competent 70S ribosomal particle (in bacteria) from separated 30S and 50S subunits and i
PMID 22722848