関: proglumetacin maleate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/05 00:46:09」(JST)

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Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,^[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

English Journal

[Sports-induced acute epicondylitis of the elbow and conservative therapy].

Förster KK, Schmid K, Reichelt A.SourceAbt. Klinische Forschung, Opfermann Arzneimittel GmbH, Wiehl Orthop. Universitätsklinik, Freiburg.
Sportverletzung Sportschaden : Organ der Gesellschaft für Orthopädisch-Traumatologische Sportmedizin.Sportverletz Sportschaden.1997 Mar;11(1):16-20.
48 patients with an acute lateral and/or medial epicondylitis of the elbow, induced by sporting activities, were treated in a prospective, controlled, double-blind, and randomised clinical study over a period of one to two weeks in a standard manner, either with taping and the oral NSAID proglumetac
PMID 9213940

[Toxicity of NSAIDs].

Deleuse L.
Revue médicale de Bruxelles.Rev Med Brux.1993 Oct;14(8):262.
PMID 8272684

Possible mechanisms of gastroduodenal mucosal damage in volunteers treated with nonsteroidal antiinflammatory drugs--the usefulness of prodrugs.

Yanagawa A, Fukumura T, Matsui H, Uemura H, Endo T, Nakagawa T, Mizushima Y.SourceInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan.
The Journal of rheumatology.J Rheumatol.1992 Jul;19(7):1075-82.
A controlled double blind study on the incidence of nonsteroidal antiinflammatory drug (NSAID) gastropathy was performed in 29 healthy volunteers administered diclofenac Na (10 subjects) or a prodrug (loxoprofen Na in 10 subjects and proglumetacin maleate in 9 subjects). The incidence of NSAID gastr
PMID 1512761

Japanese Journal

疼痛克服とDDS : 経口麻薬性鎮痛薬·非ステロイド性抗炎症薬の進歩

佐伯茂
Drug Delivery System 20(5), 521-529, 2005
徐放性麻薬性鎮痛薬には, 主成分がモルヒネであるMSコンチン, MSツワイスロン, モルペス細粒, カディアン, ピーガード錠などがある. 前3者は1日2回の内服, 後2者は1日1回の内服ですむ, 一方, アヘンから抽出されるテバインを原料に合成された麻薬:オキシコドンの徐放性製剤としてオキシコンチンがある. この薬物は1日2回の内服ですむ. これらの徐放性製剤は, がん性疼痛にのみ適応が認められ …
NAID 130000747974

マレイン酸プログルメタシンの結晶多形が溶出特性および血中動態に及ぼす影響

安友照人,白井悟,佐藤利治,矢田いく代,松田芳久,大塚誠
薬剤学 = The archives of practical pharmacy 61(3), 97-108, 2001-09-20
NAID 10007945422

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リンク元	「プログルメタシン」
拡張検索	「proglumetacin maleate」

「プログルメタシン」

Proglumetacin
Systematic (IUPAC) name
	3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N2-benzoyl-N,N-dipropyl-α-glutaminate
Clinical data
AHFS/Drugs.com	International Drug Names
Pharmacokinetic data
Metabolism	Hepatic. Undergoes enterohepatic recirculation
Identifiers
CAS Number	57132-53-3 59209-40-4
ATC code	M01AB14
PubChem	CID 4921
ChemSpider	4752
UNII	FV919079LU
ChEBI	CHEBI:76263
Synonyms	3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate
Chemical data
Formula	C46H58ClN5O8
Molar mass	844.43442 g/mol
	SMILES Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5 ;
	InChI InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) ; Key:PTXGHCGBYMQQIG-UHFFFAOYSA-N ;
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