progesterone receptors

プロゲステロン受容体, PgR

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. a steroid hormone (trade name Lipo-Lutin) produced in the ovary; prepares and maintains the uterus for pregnancy (同)Lipo-Lutin

PrepTutorEJDIC

1. =sense organ / 受信装置
2. 黄体ホルモン

UpToDate Contents

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• 1. 乳癌​における​ホルモン​受容体​：​臨床的有用性​および​検査精度向上​のための​ガイドライン​の​推奨​ hormone receptors in breast cancer clinical utility and guideline recommendations to improve test accuracy
• 2. プロゲステロン​受容体拮抗剤​および​選択的​プロゲステロン​受容体​モジュレーター​の​治療使用​および​有害作用​ therapeutic use and adverse effects of progesterone receptor antagonists and selective progesterone receptor modulators
• 3. プロゲステロン​受容体​モジュレーター​（​PRM​）​の​薬理学​および​作用機序​ pharmacology and mechanism of action of progesterone receptor modulators prms
• 4. 転移性乳癌​の​全身治療​：​一般原則​ systemic treatment for metastatic breast cancer general principles
• 5. 子宮内膜間質腫瘍​の​分類​および​治療​ classification and treatment of endometrial stromal tumors

English Journal

• Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation.

• Wiebe JP1, Pawlak KJ2, Kwok A3.
• The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Jan;155(Pt A):166-76. doi: 10.1016/j.jsbmb.2015.10.021. Epub 2015 Oct 28.
• Previous studies have shown that breast tissues and breast cell lines can convert progesterone to 5α-pregnane-3,20-dione (5aP), and that 5αP stimulates breast cell proliferation and detachment in vitro, and tumor formation in vivo, regardless of presence or absence of receptors for progesterone (P
• PMID 26519986

• Estrogen Receptor Agonists and Antagonists in the Yeast Estrogen Bioassay.

• Wang S1, Bovee TF2.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1366:337-42. doi: 10.1007/978-1-4939-3127-9_26.
• Cell-based bioassays can be used to predict the eventual biological activity of a substance on a living organism. In vitro reporter gene bioassays are based on recombinant vertebrate cell lines or yeast strains and especially the latter are easy-to-handle, cheap, and fast. Moreover, yeast cells do n
• PMID 26585147

• Lipopolysaccharide enhances apoptosis of corpus luteum in isolated perfused bovine ovaries in vitro.

• Lüttgenau J1, Möller B2, Kradolfer D2, Wellnitz O3, Bruckmaier RM2, Miyamoto A2, Ulbrich SE2, Bollwein H2.
• Reproduction (Cambridge, England).Reproduction.2016 Jan;151(1):17-28. doi: 10.1530/REP-15-0281. Epub 2015 Oct 19.
• Lipopolysaccharide (LPS), the endotoxin of Gram-negative bacteria, has detrimental effects on the structure and function of bovine corpus luteum (CL) in vivo. The objective was to investigate whether these effects were mediated directly by LPS or via LPS-induced release of PGF2α. Bovine ovaries wit
• PMID 26483517

Japanese Journal

• 皮膚浸潤をきたした乳腺腺様嚢胞癌の1例

• 原田 剛佑,折田 雅彦,林 雅規,平田 健,守田 信義,星井 嘉信,濱野 公一
• 山口医学 63(1), 43-47, 2014-02-01
• … Estrogen and progesterone receptors were negative, and no HER-2 expression in this tumor. …
• NAID 120005435146

• ABSTRACT 腸管内分泌細胞膜プロゲステロン受容体の活性化は,マウスにおいてインクレチン分泌を促進し耐糖能を改善する

• Flock Grace B.,Cao Xiemin,Maziarz Marlena [他]
• Diabetes : a journal of the American Diabetes Association 6(4), 32-34, 2013-09
• NAID 40019818387

• 唾液腺導管癌の予後因子解析とHER-2およびアンドロゲン受容体発現の免疫組織化学的検討

• 大塚 邦憲,今西 順久,羽生 昇 [他],佐藤 陽一郎,重冨 征爾,藤井 良一,坂本 耕二,冨田 俊樹,藤井 正人,亀山 香織,小川 郁
• 日本耳鼻咽喉科学会会報 116(9), 1024-1032, 2013
• 背景: 唾液腺導管癌 (SDC) はその罹患率の低さゆえに多数症例による臨床像の検討が不十分なままで, 補助全身療法を含め有効な治療法の標準化がいまだ困難である. 目的: SDCの予後因子の解析と治療標的候補分子の発現の評価 方法: 1996年から2010年までの15年間に慶應義塾大学耳鼻咽喉科で初回治療を行ったSDC16症例を対象に, 臨床統計学的および免疫組織化学的検討を行った. 結果: 全体 …
• NAID 130003385779

Related Links

• Progesterone receptor - Wikipedia, the free encyclopedia

Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action.

• Progesterone receptor - Homo sapiens (Human)

Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone- dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ...

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