関: ethopropazine、profenamine hibenzate、profenamine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/28 12:45:09」(JST)

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Profenamine (INN, trade names Parsidol, Parsidan, Parkin), also known as ethopropazine (BAN), is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

References

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English Journal

Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities.

Bahar FG1, Imai T.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2013 Jul;41(7):1450-6. doi: 10.1124/dmd.113.051805. Epub 2013 May 6.
The hydrolyzing properties of plasma esterases for aspirin were investigated in human plasma and plasma from experimental animals. The observed rates of aspirin hydrolysis were in the following order: rabbit > human > monkey > rat > mouse > dog > minipig. In human, monkey, and dog
PMID 23649702

Acetylcholinesterase and butyrylcholinesterase activities in obese Beagle dogs before and after weight loss.

Tvarijonaviciute A1, Ceron JJ, Tecles F.
Veterinary clinical pathology.Vet Clin Pathol.2013 Jun;42(2):207-11. doi: 10.1111/vcp.12032. Epub 2013 Apr 1.
BACKGROUND: Obesity is the most common nutritional disorder in today's dog population and the major risk factor for a number of related diseases. However, the exact pathogenesis of obesity-related complications is not always clear. In people, butyrylcholinesterase (BChE) is suspected to be involved
PMID 23550593

Identification of small molecules that promote human embryonic stem cell self-renewal.

Kumagai H1, Suemori H, Uesugi M, Nakatsuji N, Kawase E.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 May 17;434(4):710-6. doi: 10.1016/j.bbrc.2013.03.061. Epub 2013 Mar 27.
Human embryonic stem cells (hESCs) and induced pluripotent cells have the potential to provide an unlimited source of tissues for regenerative medicine. For this purpose, development of defined/xeno-free culture systems under feeder-free conditions is essential for the expansion of hESCs. Most defin
PMID 23541943

Japanese Journal

Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 854(1), 116-120, 2007-07-01
NAID 10025805017

「プロフェナミン」

Profenamine
Systematic (IUPAC) name
	N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Pharmacokinetic data
Protein binding	93%
Biological half-life	1 to 2 hours
Identifiers
CAS Number	1094-08-2
ATC code	N04AA05
PubChem	CID: 3290
IUPHAR/BPS	7181
DrugBank	DB00392
ChemSpider	3174
UNII	O00T1I1VRN
ChEBI	CHEBI:313639
ChEMBL	CHEMBL1206
Chemical data
Formula	C19H24N2S
Molecular mass	312.473 g/mol
	SMILES S2c1ccccc1N(c3c2cccc3)CC(N(CC)CC)C ;
	InChI InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3 ; Key:CDOZDBSBBXSXLB-UHFFFAOYSA-N ;
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