- 関
- procollagen N-endopeptidase、procollagen N-proteinase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/19 07:29:13」(JST)
wiki en
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 2型糖尿病の治療のためのジペプチジルペプチダーゼ4（DPP-4）阻害剤 dipeptidyl peptidase 4 dpp 4 inhibitors for the treatment of type 2 diabetes mellitus
- 2. エーラス・ダンロス症候群の臨床症状および診断 clinical manifestations and diagnosis of ehlers danlos syndromes
- 3. ACE 阻害薬誘発性血管浮腫 ace inhibitor induced angioedema
- 4. 2型糖尿病治療のためのGlucagon-like peptide-1受容体拮抗剤 glucagon like peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus
- 5. 肝線維症の非侵襲的評価：血清学的検査および画像診断 noninvasive assessment of hepatic fibrosis overview of serologic and radiographic tests
English Journal
- A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner.
- Hisanaga A, Morishita S, Suzuki K, Sasaki K, Koie M, Kohno T, Hattori M.SourceDepartment of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
- FEBS letters.FEBS Lett.2012 Sep 21;586(19):3349-53. doi: 10.1016/j.febslet.2012.07.017. Epub 2012 Jul 20.
- Reelin is a glycoprotein essential for brain development and functions. Reelin is subject to specific proteolysis at two distinct (N-t and C-t) sites, and these cleavages significantly diminish Reelin activity. The decrease of Reelin activity is detrimental for brain function, but the protease that
- PMID 22819337
- MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.
- Struglics A, Hansson M.SourceDepartment of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden. andre.struglics@med.lu.se
- The Biochemical journal.Biochem J.2012 Sep 1;446(2):213-23. doi: 10.1042/BJ20120274.
- Although it has been shown that aggrecanases are involved in aggrecan degradation, the role of MMP (matrix metalloproteinase) aggrecanolysis is less well studied. To investigate MMP proteolysis of human aggrecan, in the present study we used neoepitope antibodies against MMP cleavage sites and Weste
- PMID 22670872
- Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis.
- Wang L, Pawlak E, Johnson PJ, Belknap JK, Alfandari D, Black SJ.SourceDepartment of Veterinary and Animal Sciences, College of Natural Sciences, University of Massachusetts, Amherst, MA 01003, USA.
- American journal of veterinary research.Am J Vet Res.2012 Jul;73(7):1047-56. doi: 10.2460/ajvr.73.7.1047.
- OBJECTIVE: To determine whether increased gene expression of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) in laminae of horses with starch gruel-induced laminitis was accompanied by increased enzyme activity and substrate degradation.SAMPLE: Laminae from the forelimb h
- PMID 22738057
Japanese Journal
- Pro-gln: the procollagen peptidase cleavage site in the alpha 1 (I) chain of dermatosparatic calf skin procollagen.
- HORLEIN D.
- FEBS Lett 89, 279-282, 1978
- NAID 80014998742
Related Links
- Procollagen Peptidase; Procollagène peptidase. Aide pour diagnostic médical. Méthode automatique d'associations de symptômes pour classifier les plus de 4.000 maladies en quatre langues différentes ... Symptômes et diagnostics
- Definition of procollagen N-peptidase in the Medical Dictionary. procollagen N-peptidase explanation. Information about procollagen N-peptidase in Free online English dictionary. What is procollagen N-peptidase? Meaning of ? ...
Related Pictures
★リンクテーブル★
| リンク元 | 「コラーゲン」「プロコラーゲンペプチダーゼ」「procollagen N-proteinase」 |
| 関連記事 | 「peptidase」 |
「コラーゲン」
- first aid step1 2006 p.85,86,114,288,291,292,301,306,319,321,385,427
遺伝子
- COL1A1 17q22
- COL1A2 7q22.1
- COL2A1 12q13
- COL11A2 6p21.3
- これらの遺伝子の変異による結合組織疾患はdominant negative mutationである。
臨床関連
コラーゲンの種類
- HIS.97 NDE.5
| 場所 | |
| I型コラーゲン | 狭義の結合組織、骨、歯の象牙質とセメント質に存在 |
| II型コラーゲン | 硝子軟骨、弾性軟骨 |
| III型コラーゲン | 細網線維 |
| IV型コラーゲン | 基底板の緻密板を作る |
| V型コラーゲン | I型コラーゲンと関連。胎盤に存在 |
| VII型コラーゲン | 基底板を細網線維に付着。anchoring fibril |
| XVII型コラーゲン | ヘミデスモソームと基底板を連結 |
生合成
- first aid step1 2006 p.85
- ER：ER内でOH化(Pro, Lys)：preprocollagen
- Golgi：Lysの糖鎖付加：procollagen(triple helix of 3 collagen α chains)
- EM：procollagen －procollagen peptidase→ tropocollagen
- ：tropocollagen －covalent lysine-hydroxylysine cross-linkage by lysyl oxidase → collagen fibrils
「プロコラーゲンペプチダーゼ」
「procollagen N-proteinase」
- 関
- procollagen N-endopeptidase、procollagen peptidase