probenecid

出典: meddic

プロベネシド

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「a uricosuric drug that reduces the level of uric acid in the blood; used to treat gout」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/12 16:36:25」(JST)

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英文文献

  • Fuzzy optimization for detecting enzyme targets of human uric acid metabolism.
  • Hsu KC, Wang FS.SourceDepartment of Chemical Engineering, National Chung Cheng University, Chiayi 62102, Taiwan.
  • Bioinformatics (Oxford, England).Bioinformatics.2013 Dec 15;29(24):3191-8. doi: 10.1093/bioinformatics/btt564. Epub 2013 Sep 26.
  • MOTIVATION: Mathematical modeling and optimization have been used for detecting enzyme targets in human metabolic disorders. Such optimal drug design methods are generally differentiated as two stages, identification and decision-making, to find optimal targets. We developed a unified method named f
  • PMID 24078686
  • Utilization patterns of Antihyperuricemic Agents Following Safety Announcement on Allopurinol and Benzbromarone by Taiwan Food and Drug Administration.
  • Cheng CL, Chao PH, Hsu JC, Weng MM, On AW, Yang YH.SourceInstitute of Clinical Pharmacy and Pharmaceutical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Pharmacoepidemiology and drug safety.Pharmacoepidemiol Drug Saf.2013 Dec 5. doi: 10.1002/pds.3550. [Epub ahead of print]
  • OBJECTIVE: The purpose of this study is to evaluate the utilization of four approved antihyperuricemic agents in Taiwan before and after two safety announcements rescinded an indication for allopurinol and added a warning on benzbromarone-induced hepatotoxicity in the year 2005.METHODS: An interrupt
  • PMID 24307655
  • Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.
  • Huh Y, Keep RF, Smith DE.SourceDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Dec;57(12):6171-8. doi: 10.1128/AAC.01497-13. Epub 2013 Sep 30.
  • The purpose of this study was to determine if the disposition of cefadroxil, an α-amino-containing β-lactam antibiotic, changes during lipopolysaccharide (LPS)-induced acute inflammation. Six hours after LPS or saline treatment, mice received 1 nmol/g cefadroxil intravenously along with inulin for
  • PMID 24080658

和文文献

  • A simple method to evaluate reactivity of acylglucuronides optimized for early stage drug discovery
  • Jinno Norimasa,Ohashi Shigeki,Tagashira Mizuka,Kohira Terutomo,Yamada Shizuo
  • Biological and Pharmaceutical Bulletin, 2013
  • … We evaluated the half-lives of 10 drugs: 3 safe drugs (telmisartan, gemfibrozil and flufenamic acid) and 7 withdrawn or warning drugs (zomepirac, diclofenac, furosemide, ibuprofen, S-naproxen, probenecid and tolmetin). …
  • NAID 130003361534
  • Ribosomal protein L3 mediated the transport of digoxin in Xenopus laevis oocyte
  • Kobayashi Yasuna,Kawakami Kanako,Ohbayashi Masayuki [他],KOHYAMA Noriko,YAMAMOTO Toshinori
  • Journal of toxicological sciences 35(6), 827-834, 2010-12-01
  • … The maximum velocity of the transport of [3H]digoxin via RPL3 produced at physiological pH. However, we did not observe RPL3-mediated transport of several organic solutes such as [14C]androstenedione, [3H]dexamethasone, [3H]dehydroepiandrosterone sulfate, [3H]L-tryptophan, [14C]L-ascorbic acid, [14C]α-ketoglutarate, [14C]glutarate, [3H]methotrexate, [3H]bumetanide, [3H]probenecid, [14C]salicylic acid, [14C]theophylline and [3H]valproate. …
  • NAID 10026962974
  • Interactions of Human Organic Anion Transporters With Aristolochic Acids
  • Babu Ellappan,Takeda Michio,Nishida Ritsuo [他],Noshiro-Kofuji Rie,Yoshida Masaaki,Ueda Shiro,Fukutomi Toshiyuki,Anzai Naohiko,Endou Hitoshi
  • Journal of Pharmacological Sciences 113(2), 192-196, 2010
  • … Treatment of hOAT3 with AA-I resulted in a significant reduction in viability compared with that of mock, which was rescued by the organic anion transport inhibitor probenecid. …
  • NAID 130000251925

関連リンク

Probenecid (Benuryl, Benemid, Probalan) is a uricosuric drug that increases uric acid excretion in the urine. ... During World War II, probenecid was used to extend limited supplies of penicillin, and is still currently used to increase antibiotic ...
Consumer information about the medication PROBENECID - ORAL, includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug PROBENECID - ORAL.

関連画像

 del dolor > Genérico Benemid - ProbenecidProbenecid SunwardsBencid Probenecid 500 MgPROBENECID BROMANTAN DIURÉTICOS Probenecid 500 mg-MYL douleur > Generique Benemid - Probenecid


★リンクテーブル★
リンク元薬理学」「痛風治療薬」「プロベネシド

薬理学」

  [★]

pharmacology
drug entries


定義

  • 生物系と化学物質の選択的な相互作用を研究する学問 (SPC.2)

生物系と薬の相互作用

  • 薬の生物系に対する相互作用:薬理作用 <-化学の視点
  • 生物系の薬に対する相互作用:薬物動態 <-生物の視点

関連分野

  • 薬物学 materia medica
  • 生薬学
  • 実験薬理学
  • 臨床薬理学
  • 動物薬理学
  • 人体薬理学
  • 比較薬理学
  • 薬理作用学(薬力学)
  • 薬物動態学
  • 中毒学、毒科学
  • 薬物治療学
  • 処方学

薬品の命名

Ending of the drug name Category Example
~afil Erectile dysfunction sildenafil
~ane Inhalatinal general anesthetic halothane
~azepam Benzodiaizepine diazepam
~azine Phenothiazine (neuroleptic, antiemetic) chlorpromazine
~azole Ailtifungal ketoconazole
~barbital Barbiturate phenobarbital
~caine Local anesthetic lidocaine
~cillin Penicillin methicillin
~cycline Antibiotic, protein syntlesis inhibitor tetracycline
~ipramine TCA iimipramine
~navir Protease inhibitor saquinavir
~olol β-antagonist propranolol
~operidol Butyrophenone ( neuroleptic ) haloperidol
~oxin Cardiac glycoside ( inotropic agent ) digoxin
~phylline Methylxanthine theophylline
~pril ACE inhibitor captopril
~terol β2 agonist albuterol
~tidine H2 antagonist cimtidine
~triptyline TCA amitriptyline
~tropine Pituitary hormone somatotropine
~zosin a1 antagonist prazosin

薬一覧

薬物代謝

薬理動態

神経伝達物質

神経筋接合部遮断薬(筋弛緩薬)

交感神経作動薬

アドレナリン受容体

交感神経遮断薬

アドレナリン受容体

副交感神経作動薬

アセチルコリン受容体

副交感神経遮断薬

アセチルコリン受容体

貧血治療薬

甲状腺関連物質

痛風治療薬

  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬


痛風治療薬」

  [★]

arthrifuge, gout suppressant, drug for treatment of gout, antipodagric
抗痛風薬
薬理学痛風
  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬


プロベネシド」

  [★]

probenecid
probenecidum
ベネシッド Benecidプロベネミド
高尿酸血症


禁忌

  • 腎臓結石症又は高度の腎障害のある患者:尿中尿酸排泄量の増大によりこれらの症状を悪化させるおそれがある。

無効

  • 慢性腎不全 (特に糸球体濾過値30mL/分以下) の患者




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