原発性進行性失語
- 関
- PPA、progressive nonfluent aphasia
WordNet
- of first rank or importance or value; direct and immediate rather than secondary; "primary goals"; "a primary effect"; "primary sources"; "a primary interest"
- a preliminary election where delegates or nominees are chosen (同)primary_election
- one of the main flight feathers projecting along the outer edge of a birds wing (同)primary feather, primary quill
- (astronomy) a celestial body (especially a star) relative to other objects in orbit around it
- not derived from or reducible to something else; basic; "a primary instinct"
- gradually advancing in extent
- a tense of verbs used in describing action that is on-going (同)progressive tense, imperfect, imperfect tense, continuous tense
- favoring or promoting reform (often by government action) (同)reformist, reform-minded
- (of a card game or a dance) involving a series of sections for which the participants successively change place or relative position; "progressive euchre"; "progressive tournaments"
- (of taxes) adjusted so that the rate increases as the amount of income increases
- advancing in severity; "progressive paralysis"
- favoring or promoting progress; "progressive schools"
- inability to use or understand language (spoken or written) because of a brain lesion
PrepTutorEJDIC
- 『第一の』,『主要な』 / 『初期の』,『初等の』,初級の / 『根本的な』,基本的な,本来の,直接的な / 《名詞の前にのみ用いて》(回路・コイル・巻き・電流などが)一次の / 原色(三原色の一つ) / 《米》=primary election
- (行列などが)『前進する』,進んで行く / (事態が)進展する,進行する / 『進歩的な』,革新的な / (病気・暴力などが)次第に悪くなる(広がる) / (課税が)累進的な / (文法で)進行[形]の / 進歩的な人,革新主義者
- 失語症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/31 08:16:01」(JST)
[Wiki en表示]
Main article: Aphasia
| Primary progressive aphasia |
| Classification and external resources |
| OMIM |
607485 |
| MeSH |
D018888 |
Primary progressive aphasia (PPA) is a group of disorders characterized by progressive language and speech difficulties.[1] It was first described as a distinct syndrome by M.-Marsel Mesulam in 1982.[2] Primary Progressive Aphasias have a clinical and pathological overlap with the Frontotemporal Lobar Degeneration (FTLD) spectrum of disorders and Alzheimer's disease.
Contents
- 1 Classification
- 2 Diagnostic criteria
- 3 Risk Factors
- 4 Treatment
- 5 See also
- 6 References
- 7 Further reading
- 8 External links
Classification
Three classifications of primary progressive aphasia have been described.[3][4][5] In the classical Mesulam criteria for primary progressive aphasia, there are 2 variants: a non-fluent type Progressive Nonfluent Aphasia (PNFA) and a fluent type Semantic Dementia (SD).[1][6] A third variant of primary progressive aphasia, Logopenic Progressive Aphasia (LPA)[7] is an atypical form of Alzheimer's disease.
Diagnostic criteria
The following diagnosis criteria were defined by Mesulam [8]
- Gradual impairment of object naming, syntax and word-processing
- Premorbid language function is usually intact
- Acalculia: inability to perform simple mathematical calculations
- Ideomotor Apraxia: loss of the ability to execute or carry out learned purposeful movements
Risk Factors
There are no known environmental risk factors for the progressive aphasias. However, one observational, retrospective study suggested that vasectomy could be a risk factor for PPA in men.[9] These results have yet to be replicated or demonstrated by prospective studies.
PPA is not considered a hereditary disease. However, relatives of a person with any form of frontotemporal lobar degeneration, including PPA, are at slightly greater risk of developing PPA or another form of the condition.[10]
Treatment
There is no approved treatment. Rapid and sustained improvement in speech and dementia in a patient with primary progressive aphasia utilizing off-label perispinal etanercept, an anti-TNF treatment strategy also used for Alzheimer's, has been reported.[11] A video depicting the patient's improvement was published in conjunction with the print article. These findings have not been independently replicated and remain controversial.
See also
- Anomic aphasia
- Aphasiology
- Apraxia of speech
- Speech and Language Pathology
- Speech disorder
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- Transcortical sensory aphasia
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References
- ^ a b Mesulam MM (April 2001). "Primary progressive aphasia". Annals of Neurology 49 (4): 425–32. doi:10.1002/ana.91. PMID 11310619.
- ^ Mesulam M (1982). "Slowly progressive aphasia without generalized dementia". Annals of Neurology 11 (6): 592–8. doi:10.1002/ana.410110607. PMID 7114808.
- ^ Gorno-Tempini ML, Hillis AE, Weintraub S et al. (March 2011). "Classification of primary progressive aphasia and its variants". Neurology 76 (11): 1006–14. doi:10.1212/WNL.0b013e31821103e6. PMC 3059138. PMID 21325651.
- ^ Bonner MF, Ash S, Grossman M (November 2010). "The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants". Curr Neurol Neurosci Rep 10 (6): 484–90. doi:10.1007/s11910-010-0140-4. PMC 2963791. PMID 20809401.
- ^ Harciarek M, Kertesz A (September 2011). "Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship". Neuropsychol Rev 21 (3): 271–87. doi:10.1007/s11065-011-9175-9. PMC 3158975. PMID 21809067.
- ^ Adlam AL, Patterson K, Rogers TT et al. (Nov 2006). "Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?". Brain 129 (Pt 11): 3066–80. doi:10.1093/brain/awl285. PMID 17071925.
- ^ Gorno-Tempini ML, Dronkers NF, Rankin KP et al. (Mar 2004). "Cognition and anatomy in three variants of primary progressive aphasia". Annals of Neurology 55 (3): 335–46. doi:10.1002/ana.10825. PMC 2362399. PMID 14991811.
- ^ Mesulam MM: Primary progressive aphasia—a language-based dementia. N Engl J Med 2003, 349:1535–1542
- ^ Weintraub S, Fahey C, Johnson N, et al. (December 2006). "Vasectomy in men with primary progressive aphasia". Cogn Behav Neurol 19 (4): 190–3. doi:10.1097/01.wnn.0000213923.48632.ab. PMID 17159614.
- ^ Goldman JS, Farmer JM, Wood EM et al. (Dec 2005). "Comparison of family histories in FTLD subtypes and related tauopathies". Neurology 65 (11): 1817–9. doi:10.1212/01.wnl.0000187068.92184.63. PMID 16344531.
- ^ Tobinick E (2008). "Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism". Medscape Journal of Medicine 10 (6): 135. PMC 2491668. PMID 18679537.
Further reading
- Amici S, Ogar J, Brambati SM et al. (Dec 2007). "Performance in specific language tasks correlates with regional volume changes in progressive aphasia". Cognitive & Behavioral Neurology 20 (4): 203–11. doi:10.1097/WNN.0b013e31815e6265. PMID 18091068.
- Gliebus G (March 2010). "Primary progressive aphasia: clinical, imaging, and neuropathological findings". Am J Alzheimers Dis Other Demen 25 (2): 125–7. doi:10.1177/1533317509356691. PMID 20124255.
- Henry ML, Beeson PM, Alexander GE, Rapcsak SZ (February 2012). "Written language impairments in primary progressive aphasia: a reflection of damage to central semantic and phonological processes". J Cogn Neurosci 24 (2): 261–75. doi:10.1162/jocn_a_00153. PMC 3307525. PMID 22004048.
- Henry ML, Gorno-Tempini ML (December 2010). "The logopenic variant of primary progressive aphasia". Current Opinion in Neurology 23 (6): 633–7. doi:10.1097/WCO.0b013e32833fb93e. PMC 3201824. PMID 20852419.
- Reilly J, Rodriguez AD, Lamy M, Neils-Strunjas J (2010). "Cognition, language, and clinical pathological features of non-Alzheimer's dementias: an overview". J Commun Disord 43 (5): 438–52. doi:10.1016/j.jcomdis.2010.04.011. PMC 2922444. PMID 20493496.
- Rohrer JD, Knight WD, Warren JE, Fox NC, Rossor MN, Warren JD (January 2008). "Word-finding difficulty: a clinical analysis of the progressive aphasias". Brain 131 (Pt 1): 8–38. doi:10.1093/brain/awm251. PMC 2373641. PMID 17947337.
External links
- FAQ on PPA from IMPPACT, the International PPA Connection
- PPA information from the UCSF Memory and Aging Center
- Northwestern Cognitive Neurology and Alzheimer's Disease Center
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Topics related to Primary progressive aphasia
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Symptoms and signs: Speech and voice / Symptoms involving head and neck (R47–R49, 784)
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| Aphasias |
- Acute Aphasias
- Expressive aphasia
- Receptive aphasia
- Conduction aphasia
- Anomic aphasia
- Global aphasia
- Transcortical sensory aphasia
- Transcortical motor aphasia
- Mixed transcortical aphasia
- Progressive Aphasias
- Progressive nonfluent aphasia
- Semantic dementia
- Logopenic progressive aphasia
- Speech disturbances
- Speech disorder
- Developmental verbal dyspraxia/Apraxia of speech
- Auditory verbal agnosia
- Dysarthria
- Schizophasia
- Aprosodia/Dysprosody
- Specific language impairment
- Thought disorder
- Pressure of speech
- Derailment
- Clanging
- Circumstantiality
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| Communication disorders |
- Developmental dyslexia/Alexia
- Agnosia
- Astereognosis
- Prosopagnosia
- Visual agnosia
- Gerstmann syndrome
- Developmental coordination disorder/Apraxia
- Dyscalculia/Acalculia
- Agraphia
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| Voice disturbances |
- Dysphonia/Aphonia
- Bogart–Bacall syndrome
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| Nose |
- Post-nasal drip
- Epistaxis
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| Mouth |
- Orofacial pain
- Toothache
- Galvanic pain
- Barodontalgia
- Fremitus
- Tooth mobility
- Bruxism
- Trismus
- Ageusia
- Hypogeusia
- Dysgeusia
- Parageusia
- Hypergeusia
- Xerostomia
- Halitosis
- Drooling
- Hypersalivation
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| Neck |
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| Other |
- Headache
- Auditory processing disorder
- Otalgia
- Velopharyngeal inadequacy
- Velopharyngeal insufficiency
- Hypersensitive gag reflex
- Jaw claudication
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Index of psychology and psychiatry
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| Description |
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| Disorders |
- Mental and behavioral
- Mood
- Developmental
- pervasive
- dyslexia and specific
- Substance-related
- Emotional and behavioral
- Symptoms and signs
- Evaluation and testing
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| Treatment |
- Psychotherapy
- Drugs
- depression
- antipsychotics
- anxiety
- dementia
- hypnotics and sedatives
- psychostimulants, ADHD and nootropics
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Index of the mouth
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| Description |
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| Disease |
- Congenital
- face and neck
- cleft
- digestive system
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Saccadic abnormalities in frontotemporal dementia.
- Burrell JR, Hornberger M, Carpenter RH, Kiernan MC, Hodges JR.SourceFrom Neuroscience Research Australia (J.R.B., M.H., M.C.K., J.R.H.); Prince of Wales Clinical School Hospital (J.R.B., M.C.K.); University of New South Wales (J.R.B., M.H., M.C.K., J.R.H.), Sydney, Australia; and Department of Physiology, Development and Neuroscience (R.H.S.C.), University of Cambridge, Cambridge, UK.
- Neurology.Neurology.2012 May 9. [Epub ahead of print]
- OBJECTIVE: To characterize saccadic eye movements, as a marker of decision-making processes, in frontotemporal dementia (FTD).METHODS: Saccadometry was performed on a cross-section of patients with FTD, using a portable saccadometer, and results compared to matched control subjects. We used the Line
- PMID 22573637
- Primary progressive aphasia: A tale of two syndromes and the rest.
- Sajjadi SA, Patterson K, Arnold RJ, Watson PC, Nestor PJ.SourceFrom the Neurology Unit (S.A.S., K.P., R.J.A., P.J.N.), University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; and Methods Group (P.C.W.), MRC Cognition and Brain Sciences, Cambridge, UK.
- Neurology.Neurology.2012 May 9. [Epub ahead of print]
- OBJECTIVE: Primary progressive aphasia (PPA) has been proposed to comprise 3 discrete clinical subtypes: semantic, agrammatic/nonfluent, and logopenic. Recent consensus recommendations suggest a diagnostic framework based primarily on clinical and neuropsychological findings to classify these varian
- PMID 22573633
Japanese Journal
- Progressive nonfluent aphasia--近縁症候との対比 (特集 前頭側頭葉変性症)
- 楽譜を書けなくなったラヴェル--頭の中には音楽が溢れているのに,楽譜を書こうとするとそれが消えていく (特集 創造性と老年期精神神経疾患)
Related Links
- What is Primary Progressive Aphasia (PPA)? Primary Progressive Aphasia (PPA) is a rare neurological syndrome in which language capabilities become slowly and progressively impaired, while other mental functions remain ...
- Download a PDF Summary of Primary Progressive Aphasia (PPA) Primary progressive aphasia (PPA) is a form of cognitive impairment that involves a progressive loss of language function. Language is a uniquely human faculty that ...
★リンクテーブル★
[★]
- 関
- primary progressive aphasia
- 同
- pure pulmonary atresia
- 同
- pure pulmonary atresia
[★]
- 英
- primary progressive aphasia、PPA
- 関
- 進行性非流暢性失語
-PPA
- 同
- pure pulmonary atresia
[★]
進行性非流暢性失語
- 関
- primary progressive aphasia
[★]
- 一次の、第一次の、主要な、(化学)第一級の、一級の、初生の、(病名)原発性の、原発の、プライマリーの
- 関
- cardinal、chief、first-order、foremost、main、mainly、major、master、primarily、principal、principally
[★]
進行性失語症、進行性失語
- 関
- acquired aphasia、alogia、aphasia、dysphasia、global aphasia、semantic aphasia
[★]
- 関
- progressively