presomitic mesoderm

WordNet

the middle germ layer that develops into muscle and bone and cartilage and blood and connective tissue (同)mesoblast

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1. ディジョージ症候群：疫学および病因 digeorge syndrome epidemiology and pathogenesis
2. 悪性腫瘍の高カルシウム血症 hypercalcemia of malignancy
3. 先天性奇形に対するアプローチ approach to congenital malformations
4. 卵巣胚細胞腫瘍：病理学、臨床症状、および診断 ovarian germ cell tumors pathology clinical manifestations and diagnosis
5. 耳の先天異常 congenital anomalies of the ear

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.

Preuße K1, Tveriakhina L1, Schuster-Gossler K1, Gaspar C2, Rosa AI2, Henrique D2, Gossler A1, Stauber M1.
PLoS genetics.PLoS Genet.2015 Jun 26;11(6):e1005328. doi: 10.1371/journal.pgen.1005328. eCollection 2015.
Notch signalling is a fundamental pathway that shapes the developing embryo and sustains adult tissues by direct communication between ligand and receptor molecules on adjacent cells. Among the ligands are two Delta paralogues, DLL1 and DLL4, that are conserved in mammals and share a similar structu
PMID 26114479

Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity.

Shih NP1, François P2, Delaune EA3, Amacher SL4.
Development (Cambridge, England).Development.2015 May 15;142(10):1785-93. doi: 10.1242/dev.119057.
The formation of reiterated somites along the vertebrate body axis is controlled by the segmentation clock, a molecular oscillator expressed within presomitic mesoderm (PSM) cells. Although PSM cells oscillate autonomously, they coordinate with neighboring cells to generate a sweeping wave of cyclic
PMID 25968314

MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†.

Achilleos A1, Huffman NT2, Marcinkiewicyz E3, Seidah NG3, Chen Q2, Dallas SL2, Trainor PA4, Gorski JP5.
Human molecular genetics.Hum Mol Genet.2015 May 15;24(10):2884-98. doi: 10.1093/hmg/ddv050. Epub 2015 Feb 4.
Caudal regression syndrome (sacral agenesis), which impairs development of the caudal region of the body, occurs with a frequency of about 2 live births per 100 000 newborns although this incidence rises to 1 in 350 infants born to mothers with gestational diabetes. The lower back and limbs can be a
PMID 25652402

Intronic delay is essential for oscillatory expression in the segmentation clock.

Takashima Yoshiki,Ohtsuka Toshiyuki,González Aitor,Miyachi Hitoshi,Kageyama Ryoichiro
Proceedings of the National Academy of Sciences of the United States of America 108(8), 3300-3305, 2011-02-22
… The basic helix-loop-helix repressor gene Hes7 is cyclically expressed in the presomitic mesoderm (PSM) and regulates the somite segmentation. …
NAID 120002970830

伊坂弥花子,山尾将隆,作村諭一 [他],金雄,松井貴輝,別所康全,石井信
電子情報通信学会技術研究報告. NLP, 非線形問題 108(477), 71-76, 2009-03-03
体節は、脊椎動物の身体が構築される過程で形成され、背骨や骨格筋、肋骨のように分節構造をもつ器官の基礎となる。発生初期では、身体の前後軸に沿って未分節中胚葉(PSM)と呼ばれる一続きの組織が存在するが、時間が経過するにつれ、前側から逐次的に分節化していくことにより体節が形成される。分節化のタイミングが周期性を示すことから、細胞内には時を刻む機構(分節時計)が存在すると考えられている。マウスの場合、H …
NAID 110007324853