プレプロペプチド
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/29 08:28:29」(JST)
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For other uses, see Precursor (disambiguation).
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by posttranslational modification. The name of the precursor for a protein is often prefixed by pro. Examples include proinsulin and proopiomelanocortin.
Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available on short notice and/or in large quantities. Enzyme precursors are called zymogens or proenzymes. Examples are enzymes of the digestive tract in humans.
Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that targets them for secretion. Like other proteins that contain a signal peptide, their name is prefixed by pre. They are thus called pre-pro-proteins or pre-pro-peptides. [1] The signal peptide is cleaved off in the endoplasmic reticulum.[1] An example is preproinsulin.
References
- ^ a b Alberts, Bruce (2002). Molecular biology of the cell. New York: Garland Science. p. 760. ISBN 0-8153-3218-1.
English Journal
- Detection of the hepcidin prepropeptide and mature peptide in liver of rainbow trout.
- Alvarez CA, Santana PA, Guzmán F, Marshall S, Mercado LA.SourceLaboratorio de Genética e Inmunología Molecular, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile; Núcleo Biotecnológico de Curauma (NBC), Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. Electronic address: claudio.alvarez.a@mail.pucv.cl.
- Developmental and comparative immunology.Dev Comp Immunol.2013 Apr 18. pii: S0145-305X(13)00091-8. doi: 10.1016/j.dci.2013.04.002. [Epub ahead of print]
- Hepcidin is a small, cationic peptide which displays antimicrobial activities and iron regulatory function. Originally identified in mammals, this peptide is also present in fish. Hepcidin mRNA is predominantly expressed in liver and is regulated by iron and pathogen infection. In this work, we char
- PMID 23603124
- Conformation propensities of des-acyl-ghrelin as probed by CD and NMR.
- De Ricco R, Valensin D, Gaggelli E, Valensin G.SourceDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, 53100 Siena, Italy.
- Peptides.Peptides.2013 Mar 5;43C:62-67. doi: 10.1016/j.peptides.2013.02.021. [Epub ahead of print]
- Des-acyl-ghrelin is a 28 amino acid peptide secreted by both human and rat stomach. Together with ghrelin and obestatin, it is obtained by post-translational modification of a 117 aminoacid prepropeptide mainly expressed in distinct endocrine cell type in the stomach. Although its receptor has not b
- PMID 23470254
- A note on the organization and expression of β-defensin genes in Polish goats.
- Bagnicka E, Prusak B, Kościuczuk E, Jarczak J, Kaba J, Strzałkowska N, Jóźwik A, Czopowicz M, Krzyżewski J, Zwierzchowski L.SourceInstitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, Postępu 1, 05-552, Magdalenka, Poland. e.bagnicka@ighz.pl
- Journal of applied genetics.J Appl Genet.2013 Feb;54(1):125-7. doi: 10.1007/s13353-012-0124-y. Epub 2012 Nov 22.
- Nucleotide (cds) and amino acids sequences of the caprine β2-defensin genes were in silico compared to search for the sequence variation and for the LAP gene sequences in the goat genome and for the presence of LAP gene transcripts in goat tissues. The comparison of the exon sequences revealed that
- PMID 23179605
Japanese Journal
- An extracellular endo-1,4-β-xylanase from Aspergillus japonicus: purification, properties, and characterization of the encoding gene
- Wakiyama Motoki,Yoshihara Koji,Hayashi Sachio,Ohta Kazuyoshi
- Journal of bioscience and bioengineering 109(3), 227-229, 2010-03
- … The xylanase gene (xynA) encoded a 42 residue prepropeptide and a 191 residue mature protein. …
- NAID 110007612427
- Purification and properties of family-10 endo-1,4-β-xylanase from Penicillium citrinum and structural organization of encoding gene
- Wakiyama Motoki,Tanaka Hidenori,Yoshihara Koji,Hayashi Sachio,Ohta Kazuyoshi
- Journal of bioscience and bioengineering 105(4), 367-374, 2008-04-25
- … An open reading frame of xynB was interrupted by nine introns and encoded a presumed prepropeptide of 25 amino acids and a mature protein of 302 amino acids. …
- NAID 110006664226
- Purification and Properties of an Extracellular Endo-1, 4-β-Xylanase from Penicillium citrinum and Characterization of the Encoding Gene
- Tanaka Hidenori,Nakamura Toshihide,Hayashi Sachio,Ohta Kazuyoshi
- Journal of bioscience and bioengineering 100(6), 623-630, 2005-12-25
- … An open reading frame of 657 bp was interrupted by two introns of 65 and 55 bp, and encoded a presumed prepropeptide of 27 amino acids and a mature protein of 190 amino acids. …
- NAID 110002978292
Related Links
- References for "Prepropeptide" online, at universities and in literature... cyclopaedia.net ... Neuropeptides comprise the most diverse group of neuronal signaling molecules. They often occur as multiple sequence-related copies within ...
- This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine ...
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- prepropeptide, prepro-peptide
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