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1. 副腎ステロイド生合成 adrenal steroid biosynthesis
2. まれな先天性副腎過形成 uncommon congenital adrenal hyperplasias
3. 先天性リポイド副腎過形成症 congenital lipoid adrenal hyperplasia
4. 多嚢胞性卵巣症候群におけるステロイドホルモン代謝 steroid hormone metabolism in polycystic ovary syndrome
5. 成人における双極性障害：急性うつ病の薬物療法 bipolar disorder in adults pharmacotherapy for acute depression

English Journal

PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.

Shizu R1, Abe T2, Benoki S1, Takahashi M3, Kodama S1, Miayata M1, Matsuzawa A4, Yoshinari K5.
The Biochemical journal.Biochem J.2016 Feb 1;473(3):257-66. doi: 10.1042/BJ20150734. Epub 2015 Nov 16.
Growth factor-mediated hepatocyte proliferation is crucial in liver regeneration and the recovery of liver function after injury. The nuclear receptor, pregnane X receptor (PXR), is a key transcription factor for the xenobiotic-induced expression of genes associated with various liver functions. Rec
PMID 26574435

A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production.

Muta K1, Fukami T2, Nakajima M1.
Biochemical pharmacology.Biochem Pharmacol.2015 Dec 15;98(4):659-70. doi: 10.1016/j.bcp.2015.09.016. Epub 2015 Sep 25.
Acebutolol, a β-adrenergic receptor-blocker, occasionally causes drug-induced lupus erythematosus (DILE). Acebutolol is mainly metabolized to diacetolol. Because metabolic activation has been considered to be related to acebutolol-induced toxicity, we sought to identify the enzymes that are respons
PMID 26408002

The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans.

Hukkanen J1,2,3,4, Rysa J4,5,6, Makela KA3,4,7, Herzig KH3,4,7, Hakkola J4,6, Savolainen MJ8,2,3,4.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.J Physiol Pharmacol.2015 Dec;66(6):821-39.
We recently showed that pregnane X receptor (PXR) agonists cause hyperglycaemia during oral glucose tolerance test (OGTT) in rats and healthy volunteers (Rifa-1 study). We now aimed to determine if the secretion of incretin hormones, especially glucagon-like peptide-1 (GLP-1) and gastric inhibitory
PMID 26769831