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1. アンドロゲン過剰症の妊婦への対処法approach to the patient with gestational hyperandrogenism [show details]
…DNA can be detected in plasma of pregnant women as early as six weeks of gestation, and concentrations rise during pregnancy . Using quantitative polymerase chain reaction (PCR), circulating fetal DNA can …
2. 妊娠中の梅毒syphilis in pregnancy [show details]
… high risk pregnancy unit at Parkland Hospital had a Jarisch-Herxheimer reaction, including 3/3 with primary syphilis, 12/20 with secondary syphilis, and 0/10 with latent syphilis . The reaction may be more …
3. Overview of COX-2 selective NSAIDsoverview of cox 2 selective nsaids [show details]
…allergic reactions noted. As a result, sulfonamide allergy was initially not considered a contraindication to the use of valdecoxib. However, postmarketing reports of serious anaphylactoid reactions in sulfonamide-allergic… The safety of NSAIDs during pregnancy and lactation is discussed separately.…
4. トキソプラズマ症と妊娠toxoplasmosis and pregnancy [show details]
… terminate the pregnancy. Within the prenatal screening program in France, termination is discouraged unless there is definite evidence of fetal infection based on polymerase chain reaction (PCR) performed …
5. 妊娠中の風疹rubella in pregnancy [show details]
… in the United States discourages the use of rubella IgM for rubella screening in pregnancy . Polymerase chain reaction (PCR) is another option for providing presumptive diagnosis of rubella infection …

English Journal

Maternal sickle cell disease and twin pregnancy: a case series and review of the literature.

Cardosa D, Ridout A, Nanda S, Howard J, Robinson SE, Oteng-Ntim E.
Hematology (Amsterdam, Netherlands). 2019 Dec;24(1)148-158.
Maternal sickle cell disease (SCD) and multiple gestations are well known separately as causes of high-risk pregnancies, however, there is sparse information available on maternal and perinatal outcome when both conditions occur together. This case series describes the outcomes of women with materna
PMID 30345909

Prenatal exposure to thallium is associated with decreased mitochondrial DNA copy number in newborns: Evidence from a birth cohort study.

Wu M, Shu Y, Song L, Liu B, Zhang L, Wang L, Liu Y, Bi J, Xiong C, Cao Z, Xu S, Xia W, Li Y, Wang Y.
Environment international. 2019 Aug;129()470-477.
Prenatal exposure to thallium is related to adverse birth outcomes. However, little is known about the effects of prenatal exposure to thallium on the mitochondrial DNA copy number (mtDNAcn) in newborns; such knowledge might reveal a potential mechanism linking maternal thallium exposure and adverse
PMID 31158593

miR-141-5p regulate ATF2 via effecting MAPK1/ERK2 signaling to promote preeclampsia.

Wang Y, Cheng K, Zhou W, Liu H, Yang T, Hou P, Li X.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jul;115()108953.
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria. Impaired trophoblast invasion partly modulated by abnormal MAPK1/ERK2 signaling played important roles in the pathological process of preeclampsia. The objective of this study is to investigate miR-141-5p re
PMID 31075732

Japanese Journal

順天堂医学

KURODA KEIJI
順天堂醫事雑誌 65(1), 12-19, 2019
… <p>In humans, the incidence of embryo wastage and pregnancy loss is extraordinarily high; … therefore, pregnancy loss commonly occurs in reproductive women. … Furthermore, some women suffer from recurrent pregnancy loss (RPL). … 11βHSD1/GR signalling is a significant pathway for the regulation of uNK cells and inflammatory reaction upon decidualisation of HESCs, whereas the MR gene network includes retinoid metabolism. …
NAID 130007632005

妊娠・出産による女性の認知機能の変化

小谷博子
生体医工学 Annual56(Abstract), S56-S56, 2018
<p>我々は日本の妊娠・出産をした女性の認知機能を、オーストラリアの国家プロジェクトとして開発された高精度の認知機能テスト「CogHealth(コグヘルス)」を使用し、より大きな規模で長期に渡った計測を行った。すると、CogHealthにおいて、妊娠・出産による認知機能の低下は特に見られなかった。むしろ出産後の女性においては、妊娠中や未妊娠の女性よりも「記憶」に関する課題（遅延再生課題 …
NAID 130007484051

帝王切開術後に発症し,摘出子宮で子宮型羊水塞栓症と診断し得た1例

小谷知紘,堀謙輔,安藤亮介,中塚伸一,渡邉均,七堂志津香,田島里奈,伊藤公彦
産婦人科の進歩 70(1), 24-30, 2018
<p>症例は30歳の初産婦である．顕微授精にて妊娠成立し，妊娠経過に特記すべき異常は認めなかった．39週時の恥坐骨骨折による開排困難のため，40週3日に帝王切開術を実施した．術直後より性器出血が増加し，帰室時して術後1.4時間後までの総出血量は2959mlに達した．緊急に子宮動脈塞栓術を実施するも非凝固性の出血は持続し，DICの病態を呈したため，臨床的羊水塞栓症と診断し，同日に単純子宮 …
NAID 130006588880