precursor protein

• 前駆体タンパク質、前駆体タンパク、前駆タンパク質

WordNet

1. a substance from which another substance is formed (especially by a metabolic reaction)
2. a person who goes before or announces the coming of another (同)forerunner
3. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

1. (…の)前朕,前触れ《+『of』+『名』》
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/13 08:11:25」(JST)

wiki en

[Wiki en表示]

A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule. The name of the precursor for a protein is often prefixed by pro-. Examples include proinsulin and proopiomelanocortin, which are both prohormones.

Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available on short notice and/or in large quantities. Enzyme precursors are called zymogens or proenzymes. Examples are enzymes of the digestive tract in humans.

Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that targets them for secretion. Like other proteins that contain a signal peptide, their name is prefixed by pre. They are thus called pre-pro-proteins or pre-pro-peptides. The signal peptide is cleaved off in the endoplasmic reticulum. An example is preproinsulin.

Pro-sequences are areas in the protein that are essential for its correct folding, usually in the transition of a protein from an inactive to an active state. Pro-sequences may also be involved in pro-protein

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English Journal

• Partial purification and characterisation of the peptide precursors of the cocoa-specific aroma components.

• Voigt J1, Janek K2, Textoris-Taube K2, Niewienda A2, Wöstemeyer J3.
• Food chemistry.Food Chem.2016 Feb 1;192:706-13. doi: 10.1016/j.foodchem.2015.07.068. Epub 2015 Jul 17.
• Essential precursors of the cocoa-specific aroma notes are formed during fermentation of the cocoa beans by acid-induced proteolysis. It has been shown that, in addition to free amino acids, hydrophilic peptides derived from the vicilin-class(7S) globular storage protein are required for the generat
• PMID 26304401

• Potentially bioaccessible phenolics, antioxidant activity and nutritional quality of young buckwheat sprouts affected by elicitation and elicitation supported by phenylpropanoid pathway precursor feeding.

• Świeca M1.
• Food chemistry.Food Chem.2016 Feb 1;192:625-32. doi: 10.1016/j.foodchem.2015.07.058. Epub 2015 Jul 14.
• This paper presents the study on impact of elicitation and the phenylpropanoid pathway feeding on the nutritional quality, the potentially bioaccessible phenolics and the antioxidant capacity of young buckwheat sprouts. Phenolics content was increased by elicitation and feeding with tyrosine and shi
• PMID 26304392

• Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models.

• García-Osta A1, Cuadrado-Tejedor M.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1303:117-23. doi: 10.1007/978-1-4939-2627-5_5.
• The 99-amino-acid-long APP-carboxy-terminal fragment, named C99, is a membrane-bound peptide generated from the amyloid precursor protein (APP) by β-secretase cleavage and is the direct precursor of amyloid beta (Aβ). Here we describe a method for the quantification of C99. The amount of C99 is an
• PMID 26235062

Japanese Journal

• Evidence of capsaicin synthase activity of the Pun1-encoded protein and its role as a determinant of capsaicinoid accumulation in pepper

• Ogawa Kana,Murota Katsunori,Shimura Hanako,Furuya Misaki,Togawa Yasuko,Matsumura Takeshi,Masuta Chikara
• BMC plant biology 15, 93, 2015-03-29
• … The putative aminotransferase (pAMT) and Pungent gene 1 (Pun1) proteins are believed to catalyze the second to last and the last steps in the pathway, respectively, making the Pun1 protein the putative capsaicin synthase. … Results: To verify that the Pun1 protein actually plays a role in capsaicin production, we generated anti-Pun1 antibodies against an Escherichia coli-synthesized Pun1 protein and used them to antagonize endogenous Pun1 activity. …
• NAID 120005611258

• An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

• Kizuka Yasuhiko,Kitazume Shinobu,Fujinawa Reiko,Saito Takashi,Iwata Nobuhisa,Saido Takaomi C.,Nakano Miyako,Yamaguchi Yoshiki,Hashimoto Yasuhiro,Staufenbiel Matthias,Hatsuta Hiroyuki,Murayama Shigeo,Manya Hiroshi,Endo Tamao,Taniguchi Naoyuki
• EMBO Molecular Medicine 7(2), 175-189, 2015-02-01
• … The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). … Analysis of knockout mice lacking the biosynthetic enzyme for bisecting GlcNAc, GnT-III (Mgat3), revealed that cleavage of Aβ-precursor protein (APP) by BACE1 is reduced in these mice, resulting in a decrease in Aβ plaques and improved cognitive function. …
• NAID 120005549837

• Cytoplasmic Fragment of Alcadein alpha Generated by Regulated Intramembrane Proteolysis Enhances Amyloid beta-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage

• Takei Norio,Sobu Yuriko,Kimura Ayano,Urano Satomi,Piao Yi,Araki Yoichi,Taru Hidenori,Yamamoto Tohru,Hata Saori,Nakaya Tadashi,Suzuki Toshiharu
• Journal of biological chemistry 290(2), 987-995, 2015-01-09
• … The neural type I membrane protein Alcadein alpha (Alc alpha), is primarily cleaved by amyloid beta-protein precursor (APP) alpha-secretase to generate a membrane-associated carboxyl-terminal fragment (Alc alpha CTF), which is further cleaved by gamma-secretase to secrete p3-Alc alpha peptides and generate an intracellular cytoplasmic domain fragment (Alc alpha ICD) in the late secretory pathway. …
• NAID 120005567733

Related Links

• Amyloid precursor proteinとは - goo Wikipedia (ウィキペディア)

^Hynes, T. R.; Randal, M.; Kennedy, L. A.; Eigenbrot, C.; Kossiakoff, A. A. (1990). "X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor". Biochemistry 29 (43): 10018–10022. doi:10 ...

• Amyloid precursor protein | definition of amyloid precursor ...

amyloid precursor protein (APP), a large transmembrane glycoprotein expressed on the cell surface and of uncertain function; it may be cleaved on the cell surface to a soluble form. Alternatively, cleavage may follow endocytosis and ...

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★リンクテーブル★

リンク元	「前駆タンパク質」
拡張検索	「amyloid precursor protein secretase」「amyloid beta precursor protein」「amyloid precursor protein」「amyloid precursor proteins」
関連記事	「precursor」

「前駆タンパク質」

　　[★]

英

precursor protein

関

前駆体タンパク、前駆体タンパク質

「amyloid precursor protein secretase」

　　[★]

アミロイド前駆タンパク質セクレターゼ、アミロイド前駆タンパク質分泌酵素

関

alpha-secretase、beta-secretase、gamma-secretase、secretase

「amyloid beta precursor protein」

　　[★]

• アミロイドβ前駆体タンパク質

関

amyloid beta-protein precursor

「amyloid precursor protein」

　　[★] アミロイド前駆体蛋白質 APP

「amyloid precursor proteins」

　　[★] アミロイド前駆体蛋白質

「precursor」

　　[★]

• n.

• 前駆物質、前駆体、先駆物質、前駆型の

関

progenitor