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1. HIV感染に対する曝露前予防 pre exposure prophylaxis against hiv infection
2. 肝硬変患者における静脈瘤出血に対する一次予防および静脈瘤形成予防 primary and pre primary prophylaxis against variceal hemorrhage in patients with cirrhosis
3. 癌関連疲労：治療 cancer related fatigue treatment
4. 既存の慢性肝疾患を有する女性における妊娠 pregnancy in women with pre existing chronic liver disease
5. 2型糖尿病の予防 prevention of type 2 diabetes mellitus

English Journal

The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins.

Hessle V, Björk P, Sokolowski M, González de Valdivia E, Silverstein R, Artemenko K, Tyagi A, Maddalo G, Ilag L, Helbig R, Zubarev RA, Visa N.SourceDepartment of Molecular Biology and Functional Genomics, Stockholm University, SE-10691 Stockholm, Sweden.
Molecular biology of the cell.Mol Biol Cell.2009 Aug;20(15):3459-70. doi: 10.1091/mbc.E09-01-0079. Epub 2009 Jun 3.
Eukaryotic cells have evolved quality control mechanisms to degrade aberrant mRNA molecules and prevent the synthesis of defective proteins that could be deleterious for the cell. The exosome, a protein complex with ribonuclease activity, is a key player in quality control. An early quality checkpoi
PMID 19494042

Actin-associated hnRNP proteins as transacting factors in the control of mRNA transport and localization.

Percipalle P, Raju CS, Fukuda N.SourceDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. piergiorgio.percipalle@ki.se
RNA biology.RNA Biol.2009 Apr-Jun;6(2):171-4. Epub 2009 Apr 17.
Upon nuclear export, RNP particles are either localized to polysomes or further assembled into larger RNA granules which are transported to the cellular periphery for localized translation. These mechanisms are important for asymmetric mRNA and protein distribution and have profound impact on cellul
PMID 19276667

In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences.

Raju CS, Göritz C, Nord Y, Hermanson O, López-Iglesias C, Visa N, Castelo-Branco G, Percipalle P.SourceDepartment of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm SE-171 77, Sweden.
Molecular biology of the cell.Mol Biol Cell.2008 Jul;19(7):3008-19. doi: 10.1091/mbc.E07-10-1083. Epub 2008 May 14.
Heterogeneous ribonucleoproteins (hnRNPs) have key roles in RNA biogenesis, including pre-mRNP assembly, transport and cytoplasmic localization. Here we show by biochemical fractionation of nuclear extracts and protein-protein interaction assays that the A/B-type hnRNP CBF-A is in a multiprotein com
PMID 18480411

Related Pictures

cargo with NES (leu-rich) export through Figure - Nature Structural & Molecular Figure 1 - Assembly of the U2-dependent : Splicing, Translation And mRNP Dynamics Figure 3 : Exporting RNA from the nucleus Export of mRNA-mRNPs: