WordNet

any tiny hole admitting passage of a liquid (fluid or gas)
any small opening in the skin or outer surface of an animal
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
of or relating to substances that are toxic to cells

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1. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
2. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
3. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis
4. 幼児の食物蛋白誘発性直腸炎/大腸炎および腸疾患 food protein induced proctitis colitis and enteropathy of infancy
5. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis

Cytotoxic activity and degradation patterns of structural proteins by corneal isolates of Acanthamoeba spp.

Sant'ana VP1, Carrijo-Carvalho LC, Foronda AS, Chudzinski-Tavassi AM, de Freitas D, de Carvalho FR.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie.Graefes Arch Clin Exp Ophthalmol.2015 Jan;253(1):65-75. doi: 10.1007/s00417-014-2783-3. Epub 2014 Aug 27.
BACKGROUND: Proteolytic enzymes secreted by trophozoites (amoebic secretome) are suggested as the main virulence factor involved in the severity of Acanthamoeba keratitis. The degradation profile of the main glycoprotein components of anterior and posterior portions of the cornea and the cytopathic
PMID 25161076

A bivalent typhoid live vector vaccine expressing both chromosome- and plasmid-encoded Yersinia pestis antigens fully protects against murine lethal pulmonary plague infection.

Galen JE1, Wang JY2, Carrasco JA2, Lloyd SA3, Mellado-Sanchez G3, Diaz-McNair J3, Franco O3, Buskirk AD3, Nataro JP3, Pasetti MF3.
Infection and immunity.Infect Immun.2015 Jan;83(1):161-72. doi: 10.1128/IAI.02443-14. Epub 2014 Oct 20.
Live attenuated bacteria hold great promise as multivalent mucosal vaccines against a variety of pathogens. A major challenge of this approach has been the successful delivery of sufficient amounts of vaccine antigens to adequately prime the immune system without overattenuating the live vaccine. He
PMID 25332120

Brennan AJ1, House IG2, Oliaro J2, Ramsbottom KM3, Hagn M3, Yagita H4, Trapani JA5, Voskoboinik I6.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.
Cytotoxic lymphocytes destroy pathogen-infected and transformed cells through the cytotoxic granule exocytosis death pathway, which is dependent on the delivery of proapoptotic granzymes into the target cell cytosol by the pore-forming protein, perforin. Despite the importance of mouse models in und
PMID 25348626

Li Qing
Journal of Nippon Medical School 74(2), 92-105, 2007
… OPs also affect the immune response, including effects on antibody production, interleukin-2 production, T cell proliferation, decrease of CD5 cells, and increases of CD26 cells and autoantibodies, Th1/Th2 cytokine profiles, and the inhibition of natural killer (NK) cell, lymphokine-activated killer (LAK) cell, and cytotoxic T lymphocyte (CTL) activities. …
NAID 130004146906

Temperature- and pH-Dependent Cytotoxic Effect of the Hemolytic Lectin CEL-III from the Marine Invertebrate Cucumaria echinata on Various Cell Lines

Oda Tatsuya,Tsuru Misao,Hatakeyama Tomomitsu [他],NAGATOMO Haruna,MURAMATSU Tsuyoshi,YAMASAKI Nobuyuki
The journal of biochemistry 121(3), 560-567, 1997-03-01
NAID 10005456238

Temperature- and pH-Dependent Cytotoxic Effect of the Hemolytic Lectin CEL-III from the Marine Invertebrate Cucumaria echinata on Various Cell Lines.

Oda Tatsuya,Tsuru Misao,Hatakeyama Tomomitsu,Nagatomo Haruna,Muramatsu Tsuyoshi,Yamasaki Nobuyuki
The Journal of Biochemistry 121(3), 560-567, 1997
… These results suggest that CEL-III exhibits cytotoxicity through damaging the plasma membrane by pore-form-ation in a temperature- and pH-dependent manner. … Different susceptibility of each cell line to CEL-III cytotoxicity may be due to differences in the processes leading to pore-formation after binding to cell-surface carbohydrates. …
NAID 130003533140