English Journal

De A1, Dainichi T1, Rathinam CV2, Ghosh S3.
EMBO reports.EMBO Rep.2014 May 30. pii: e201338305. [Epub ahead of print]
A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a ubiquitin-editing enzyme that removes K63-linked ubiquitin chains from adaptor proteins, such as RIP1, and then conjugates them to K48-linked polyubiquitin chains to trig
PMID 24878851

Snail1-dependent transcriptional repression of Cezanne2 in hepatocellular carcinoma.

Xu Z1, Pei L1, Wang L2, Zhang F1, Hu X3, Gui Y3.
Oncogene.Oncogene.2014 May 29;33(22):2836-45. doi: 10.1038/onc.2013.243. Epub 2013 Jun 24.
High malignancy and early metastasis are the hallmarks of hepatocellular carcinoma (HCC). Here, we report that Cezanne2 expression is downregulated in HCC cells and in HCC patients' tumorous tissues and that Cezanne2 is inversely associated with Snail1 expression in HCC patients' tumorous tissues. C
PMID 23792447

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response.

Rajsbaum R1, Versteeg GA2, Schmid S3, Maestre AM3, Belicha-Villanueva A1, Martínez-Romero C1, Patel JR1, Morrison J1, Pisanelli G4, Miorin L1, Laurent-Rolle M1, Moulton HM5, Stein DA5, Fernandez-Sesma A3, tenOever BR1, García-Sastre A6.
Immunity.Immunity.2014 May 28. pii: S1074-7613(14)00180-0. doi: 10.1016/j.immuni.2014.04.018. [Epub ahead of print]
Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of hundreds of IFN-I-stimulated genes (ISGs). The full breadth of ISG induction demands activation of a number of cellular factors including the IκB
PMID 24882218

Japanese Journal

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

Watanabe Masashi,Takahashi Hidehisa,Saeki Yasushi,Ozaki Takashi,Itoh Shihori,Suzuki Masanobu,Mizushima Wataru,Tanaka Keiji,Hatakeyama Shigetsugu
Elife 4, e05615, 2015-04-23
… Here, we show that a novel ubiquitin E3 ligase, tripartite motif protein 23 (TRIM23), stabilizes PPAR gamma protein and mediates atypical polyubiquitin conjugation. … Our results suggest that TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing PPAR gamma protein possibly via atypical polyubiquitin conjugation. …
NAID 120005617283

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

Morimoto Daichi,Walinda Erik,Fukada Harumi,Sou Yu-Shin,Kageyama Shun,Hoshino Masaru,Fujii Takashi,Tsuchiya Hikaru,Saeki Yasushi,Arita Kyohei,Ariyoshi Mariko,Tochio Hidehito,Iwai Kazuhiro,Namba Keiichi,Komatsu Masaaki,Tanaka Keiji,Shirakawa Masahiro
Nature Communications 6, 2015-01-20
… Furthermore, when expressed in cells, polyubiquitin chains covalently linked to EGFP also form aggregates depending on chain length. … We propose a novel model in which the physical and chemical instability of polyubiquitin chains drives the formation of fibrils, which then serve as an initiation signal for autophagy. …
NAID 120005528125

Iwai Kazuhiro
Biochimica et biophysica acta 1843(1), 129-136, 2014-01
… Several types of polyubiquitin chains exist and the type of chain seems to determine how ubiquitinated proteins are regulated. … Roles of non-degradable types of polyubiquitin chains such as K63, linear and K11 chains in NF-κB activation is one of the big issues in NF-κB research. … Thus, this short article discusses the differential roles of those polyubiquitin chains in NF-κB activation. …
NAID 120005359196