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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/12 13:42:03」(JST)

Polythiazide is a thiazide diuretic.^[1]^[2] A diuretic is any substance that promotes the production of urine.

References

^ O'Brien, E. T.; MacKinnon, J. (1972). "Propranolol and polythiazide in treatment of hypertension". British heart journal. 34 (10): 1042–1044. doi:10.1136/hrt.34.10.1042. PMC 458544 . PMID 5086971.
^ Monroy, A.; Plata, C.; Hebert, S. C.; Gamba, G. (2000). "Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: A new model for ions and diuretics interaction". American Journal of Physiology. Renal Physiology. 279 (1): F161–F169. PMID 10894798.

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TargetHunter: an in silico target identification tool for predicting therapeutic potential of small organic molecules based on chemogenomic database.

Wang L1, Ma C, Wipf P, Liu H, Su W, Xie XQ.
The AAPS journal.AAPS J.2013 Apr;15(2):395-406. doi: 10.1208/s12248-012-9449-z. Epub 2013 Jan 5.
PMID 23292636

Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.

Frindt G1, McNair T, Dahlmann A, Jacobs-Palmer E, Palmer LG.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2002 Oct;283(4):F717-26.
PMID 12217863

Biopharmaceutical Studies of Thiazide Diuretics. I. Determination of pK_a Values and Partition Coefficients of Thiazide Diuretics

山崎勝,鈴鹿卓美,伊東容子,伊藤壮一,北村美保子,大橋佳代子,武田美雄,鎌田皎,折田義正,中浜肇
Chemical & pharmaceutical bulletin 32(6), 2380-2386, 1984-06-25
The overlapping pK_a values of several thiazide diuretics were determined at 25±2℃ by an improved spectrophotometric method. The absorbance of the ionized form cannot be measured directly due to the o …
NAID 110003663605

Studies on Molecular Pharmacology of Thiazide Diuretics:Electron Accepting Nature of Thiazide Diuretics, Fluorescence Quenching Ability

折田義正,安東明夫,白井大禄,上田尚彦,中田一洋,福原吉典,小浜基郎,浦壁重治,阿部裕
Proceedings of the Symposium on Chemical Physiology and Pathology 12(0), 290-295, 1973
… Sulfanilamide, chlorothiazide, trichlormethiazide, polythiazide, cyclopenthiazide and diazoxide were dissolved in a pyrene (4×10-4 …
NAID 130003355176

Effect of Various Diuretics on the Activity of Mg Activated Na, K-Dependent ATPase

折田義正,高光義博,安東明夫,白井大禄,杉田実,浦壁重治,阿部裕
Ikagaku Shinpojumu 10(0), 164-168, 1971
… similarity to the electronic state of the phosphate part of ATP. This study attempted to demonstrate experimentally the metal chelation of thiazide diuretics and to investigate the effects of this metal chelating action on the activity of Na, K-dependent ATPase which had been prepared from 0.1% DOC treated microsome fragments of the rat kidney cortex. Reduction potential of a mixed solution of 2mM thiazide diuretics (hydrochlorothiazide, acetothiazide, trichlormethiazide, polythiazide and benzthiazide) with 1mM CuCl2 …
NAID 130003358498

Polythiazide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601101
ATC code	C03AA05 (WHO);
Identifiers
	IUPAC name 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;
CAS Number	346-18-9 ;
PubChem CID	4870;
IUPHAR/BPS	7274;
ChemSpider	4704 ;
UNII	36780APV5N;
KEGG	D00657 ;
ChEMBL	CHEMBL1587 ;
ECHA InfoCard	100.005.881
Chemical and physical data
Formula	C11H13ClF3N3O4S3
Molar mass	439.88 g/mol
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v t e Symporter inhibitors
Na⁺-Cl⁻	Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide; Others: Chlortalidone (chlorthalidone) Metolazone
Na⁺-K⁺-Cl⁻	Bumetanide Furosemide
See also: Receptor/signaling modulators