・リグルタミン酸
- 関
- polyglutamate
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/28 16:59:04」(JST)
[Wiki en表示]
Polyglutamic acid
Gamma PGA
|
Names |
Systematic IUPAC name
Poly[imino[1-carboxy-4-oxo-1,4-butanediyl]]
|
Identifiers |
CAS Number
|
25736-27-0 |
Properties |
Chemical formula
|
(C5H7NO3)n |
Molar mass |
variable |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Infobox references |
|
|
Polyglutamic acid (PGA) is a polymer of the amino acid glutamic acid (GA). Gamma PGA (Poly-γ-glutamic acid, γ-PGA) - the form where the peptide bonds are between the amino group of GA and the carboxyl group at the end of the GA side chain) - is a major constituent of the Japanese food natto. Gamma PGA is formed by bacterial fermentation.
Gamma PGA has a wide number of potential uses ranging from food and medicine to water treatment. It is widely being used as a drug delivery system in cancer treatment[1] and research is underway for its application in a treatment of type I diabetes and its potential use in the production of an AIDS vaccine.
References
- ^ C. Li; D.F. Yu; A. Newman; F. Cabral; C. Stephens; N.R. Hunter; L. Milas; S. Wallace (1998). "Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate". Cancer Res. 58 (11): 2404–2409. PMID 9622081.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Biocompatible anionic polyelectrolyte for improved liposome based gene transfection.
- Chen M1, Zeng Z1, Qu X1, Tang Y1, Long Q1, Feng X2.
- International journal of pharmaceutics.Int J Pharm.2015 Jul 25;490(1-2):173-9. doi: 10.1016/j.ijpharm.2015.05.046. Epub 2015 May 21.
- Cationic liposomes have been widely used as efficient gene carriers. However, the serious cytotoxicity caused by exposed positive charges restricts the further application of those kinds of gene vectors. Thus, it is challenging to develop biocompatiable non-positive charge carriers to achieve high g
- PMID 26004001
- Stereochemistry of Amino Acid Spacers Determines the Pharmacokinetics of (111)In-DOTA-Minigastrin Analogues for Targeting the CCK2/Gastrin Receptor.
- Kolenc Peitl P1, Tamma M2, Kroselj M1, Braun F3, Waser B4, Reubi JC4, Sollner Dolenc M5, Maecke HR2,3, Mansi R2,3.
- Bioconjugate chemistry.Bioconjug Chem.2015 Jun 17;26(6):1113-9. doi: 10.1021/acs.bioconjchem.5b00187. Epub 2015 May 20.
- The metabolic instability and high kidney retention of minigastrin (MG) analogues hamper their suitability for use in peptide-receptor radionuclide therapy of CCK2/gastrin receptor-expressing tumors. High kidney retention has been related to N-terminal glutamic acids and can be substantially reduced
- PMID 25971921
- Enhanced in vivo therapeutic efficacy of plitidepsin-loaded nanocapsules decorated with a new poly-aminoacid-PEG derivative.
- Lollo G1, Hervella P2, Calvo P3, Avilés P3, Guillén MJ3, Garcia-Fuentes M1, Alonso MJ1, Torres D4.
- International journal of pharmaceutics.Int J Pharm.2015 Apr 10;483(1-2):212-9. doi: 10.1016/j.ijpharm.2015.02.028. Epub 2015 Feb 11.
- The focus of this study is to disclose a new delivery carrier intended to improve the pharmacokinetic characteristics of the anticancer drug plitidepsin and to favor its accumulation within the tumor. These nanocarriers named as nanocapsules, consist of an oily core surrounded by a highly PEGylated
- PMID 25681727
Japanese Journal
- Safe and Effective Delivery of Small Interfering RNA with Polymer- and Liposomes-Based Complexes
- Kodama Yukinobu,Harauchi Satoe,Kawanabe Saki,Ichikawa Nobuhiro,Nakagawa Hiroo,Muro Takahiro,Higuchi Norihide,Nakamura Tadahiro,Kitahara Takashi,Sasaki Hitoshi
- Biological and Pharmaceutical Bulletin 36(6), 995-1001, 2013-06-01
- … Anti-luciferase siRNA was used as a model of nucleic acid medicine. … The ternary complexes were constructed by the addition of γ-polyglutamic acid (γ-PGA) to the binary complexes. …
- NAID 120005303648
- Ocular Gene Delivery Systems Using Ternary Complexes of Plasmid DNA, Polyethylenimine, and Anionic Polymers
- Kurosaki Tomoaki,Uematsu Masafumi,Shimoda Kenichiro [他],Suzuma Kiyoshi,Nakai Masato,Nakamura Tadahiro,Kitahara Takashi,Kitaoka Takashi,Sasaki Hitoshi
- Biological and Pharmaceutical Bulletin 36(1), 96-101, 2013-01-00
- … Ternary complexes were constructed by coating plasmid DNA (pDNA)/polyethylenimine (PEI) complex with anionic polymers such as γ-polyglutamic acid (γ-PGA) and chondroitin sulfate (CS). …
- NAID 120005230731
- Development of Effective Cancer Vaccine Using Targeting System of Antigen Protein to APCs.
- Kurosaki Tomoaki,Kitahara Takashi,Nakamura Tadahiro,Nishida Koyo,Fumoto Shintaro,Kodama Yukinobu,Nakagawa Hiroo,Higuchi Norihide,Sasaki Hitoshi
- Pharmaceutical Research -(-), --, 2011-09-02
- … METHODS: The novel delivery system was constructed with antigen protein, benzalkonium chloride (BK), and γ-polyglutamic acid (γ-PGA), using ovalbumin (OVA) as a model antigen protein and evaluating its immune induction effects and utilities for cancer vaccine. …
- NAID 120003457268
Related Links
- Lubon Biology Co.,Ltd major in producing Polyglutamic acid,We are looking forward to business cooperation with you on the basis of sincerity and mutual benefit ... Lubon Biology Co.,Ltd is one sub-company of Lubon Industry Co ...
- Polyglutamic Acid Cross-linked Polyglutamic Acid Glutamic acid has 2 carboxyl groups. One of them, carboxyl group is linked with amino group and PGA is formed. Cross-linked polyglutamic acid consists of mesh structure of tens ...
Related Pictures
★リンクテーブル★
[★]
- 英
- polyglutamic acid、polyglutamate
- 同
- (Glu)n
[★]
・リグルタミン酸
- 関
- polyglutamic acid
[★]
プテロイル・リグルタミン酸