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1. メトトレキサートを使用した関節リウマチ治療 use of methotrexate in the treatment of rheumatoid arthritis
2. 移植片対宿主病の予防および治療に使用される免疫抑制剤の概要 overview of immunosuppressive agents used for prevention and treatment of graft versus host disease
3. ビタミンB12および葉酸欠乏症の病因および臨床症状 etiology and clinical manifestations of vitamin b12 and folate deficiency
4. 高用量メトトレキサートの治療使用および毒性 therapeutic use and toxicity of high dose methotrexate
5. ビタミンB12および葉酸欠乏症の生理学 physiology of vitamin b12 and folate deficiency

English Journal

Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin.

Zhang P1, Xu Y2, Zhu X2, Huang Y3.
International journal of pharmaceutics.Int J Pharm.2015 Nov 2. pii: S0378-5173(15)30346-X. doi: 10.1016/j.ijpharm.2015.10.078. [Epub ahead of print]
Oral administration of insulin remains a challenge due to its poor enzymatic stability and inefficient permeation across epithelium. We herein developed a novel self-assembled polyelectrolyte complex nanoparticles by coating insulin-loaded dodecylamine-graft-γ-polyglutamic acid micelles with trimet
PMID 26541299

Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications.

Duro-Castano A1, England RM1, Razola D2, Romero E2, Oteo-Vives M2, Morcillo MA2, Vicent MJ1.
Molecular pharmaceutics.Mol Pharm.2015 Oct 5;12(10):3639-49. doi: 10.1021/acs.molpharmaceut.5b00358. Epub 2015 Sep 23.
There is a need to develop new and innovative polymer carriers to be used as drug delivery systems and/or imaging agents owing to the fact that there is no universal polymeric system that can be used in the treatment of all diseases. Additionally, limitations with existing systems, such as a lack of
PMID 26355563

Kolbach-Mandel AM1, Kleinman JG1, Wesson JA2,3.
Urolithiasis.Urolithiasis.2015 Oct;43(5):397-409. doi: 10.1007/s00240-015-0781-5. Epub 2015 May 28.
Crystal growth rates have been extensively studied in calcium oxalate monohydrate (COM) crystallization, because COM crystals are the principal component in most kidney stones. Constant composition methods are useful for studying growth rates, but fail to differentiate concurrent nucleation and aggr
PMID 26016572

Role of Methotrexate Polyglutamation and Reduced Folate Carrier 1 (RFC1) Gene Polymorphisms in Clinical Assessment Indexes

Erythrocyte Methotrexate-polyglutamate Assay Using Fluorescence Polarization Immunoassay Technique: Application to the Monitoring of Patients with Rheumatoid Arthritis