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1. 肝グリコーゲン合成酵素欠損症（糖原病0型） liver glycogen synthase deficiency glycogen storage disease 0
2. 低アルドステロン症（4型RTA）の病因、診断、および治療 etiology diagnosis and treatment of hypoaldosteronism type 4 rta
3. 呼気中一酸化窒素の分析および適用 exhaled nitric oxide analysis and applications
4. ポルフィリン症：概要 porphyrias an overview
5. 虚血性脳卒中の病態生理 pathophysiology of ischemic stroke

English Journal

Effects of polydeoxyribonucleotide on the histological damage and the altered spermatogenesis induced by testicular ischaemia and reperfusion in rats.

Minutoli L1, Antonuccio P, Squadrito F, Bitto A, Nicotina PA, Fazzari C, Polito F, Marini H, Bonvissuto G, Arena S, Morgia G, Romeo C, Caputi AP, Altavilla D.
International journal of andrology.Int J Androl.2012 Apr;35(2):133-44. doi: 10.1111/j.1365-2605.2011.01194.x. Epub 2011 Jun 8.
The effects of polydeoxyribonucleotide (PDRN), an agonist of the A2A adenosine receptors which when activated positively influences sperm activity, were tested in an experimental testicular ischaemia/reperfusion injury model. Anaesthetized male Sprague-Dawley rats were subjected to testicular torsio
PMID 21651579

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.

Polito F1, Bitto A, Galeano M, Irrera N, Marini H, Calò M, Squadrito F, Altavilla D.
Journal of vascular surgery.J Vasc Surg.2012 Feb;55(2):479-88. doi: 10.1016/j.jvs.2011.07.083. Epub 2011 Nov 3.
BACKGROUND: Ischemia is a major factor contributing to failure of skin flap surgery, which is routinely used for coverage of wounds to prevent infection and to restore form and function. An emerging concept is that adenosine A(2A) receptors can improve tissue oxygenation by stimulating angiogenesis,
PMID 22051873

Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury.

Bitto A1, Galeano M, Squadrito F, Minutoli L, Polito F, Dye JF, Clayton EA, Calò M, Venuti FS, Vaccaro M, Altavilla D.
Critical care medicine.Crit Care Med.2008 May;36(5):1594-602. doi: 10.1097/CCM.0b013e318170ab5c.
OBJECTIVE: Polydeoxyribonucleotide contains a mixture of nucleotides and interacts with adenosine receptors, stimulating vascular endothelial growth factor expression and wound healing. The purpose of this study was to investigate the effect of polydeoxyribonucleotide on experimental burn wounds.DES
PMID 18434887