・ロクサマー188
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English Journal
- Single-step preparation and deagglomeration of itraconazole microflakes by supercritical antisolvent method for dissolution enhancement.
- Sathigari SK, Ober CA, Sanganwar GP, Gupta RB, Babu RJ.SourceDepartment of Pharmacal Sciences, Auburn University, Auburn, Alabama 36849.
- Journal of pharmaceutical sciences.2011 Jul;100(7):2952-65. doi: 10.1002/jps.22524. Epub 2011 Feb 22.
- Itraconazole (ITZ) microflakes were produced by supercritical antisolvent (SAS) method and simultaneously mixed with pharmaceutical excipients in a single step to prevent drug agglomeration. Simultaneous ITZ particle formation and mixing with fast-flo lactose (FFL) was performed in a high-pressure s
- PMID 21344415
- Facilitated nanoscale delivery of insulin across intestinal membrane models.
- Woitiski CB, Sarmento B, Carvalho RA, Neufeld RJ, Veiga F.SourceCenter for Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; Chemical Engineering Department, Queen's University, Kingston, Ontario K7L 3N6, Canada.
- International journal of pharmaceutics.2011 Jun 30;412(1-2):123-31. Epub 2011 Apr 8.
- The effect of nanoparticulate delivery system on enhancing insulin permeation through intestinal membrane was evaluated in different intestinal epithelial models using cell cultures and excised intestinal tissues. Multilayered nanoparticles were formulated by encapsulating insulin within a core cons
- PMID 21501675
Japanese Journal
- Enhancement of Wettability and Dissolution Properties of Cilostazol Using the Supercritical Antisolvent Process: Effect of Various Additives
- Kim Min-Soo,Kim Jeong-Soo,Hwang Sung-Joo
- CHEMICAL & PHARMACEUTICAL BULLETIN 58(2), 230-233, 2010
- … The solid state of particles precipitated from dichloromethane containing additives, including poloxamer 188, poloxamer 407, TPGS 1000, Gelucire® … Poloxamer 188 and poloxamer 407 were superior in increasing the dissolution rate due to decreased particle size, the resulting increased surface area, and improved wettability. …
- NAID 130000161598
- Preparation, Characterization and Evaluation of Coenzyme Q10 Binary Solid Dispersions for Enhanced Solubility and Dissolution(Biopharmacy)
- BHANDARI Krishna Hari,NEWA Madhuri,KIM Jung Ae,YOO Bong Kyu,WOO Hong Soo,LYOO Won Seok,LIM Hyun Tae,CHOI Han Gon,YONG Chul Soon
- Biological & pharmaceutical bulletin 30(6), 1171-1176, 2007-06-01
- … Phase solubility behavior of coenzyme Q10 (CoQ10) at 25℃ in various molar solutions of poloxamer 188 (P188) in water was observed and their binary solid dispersions (BSD) at different weight ratios were prepared by a simple, rapid, cost effective, uncomplicated and potentially scalable low temperature melting method. … Solubility of CoQ10 increased with increasing concentrations of P188 in water. …
- NAID 110006278415
Related Links
- POLOXAMER 188 中文名称 泊洛沙姆 188 定義 本品は、ポリオキシエチレン、ポリオキシプロピレンのブロック共重合体であり、次の化学式で表される。 配合目的 抗菌剤、洗浄剤 規制分類 CAS 9003-11-6(generic) RTECS 有機性値 ...
- The Food and Drug Administration (FDA) includes Poloxymers on its list of indirect food additives. These ingredients are permitted for use in sanitizing solutions that have incidental contact with food. Poloxamer 188 is also approved ...
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