English Journal

Platonin mitigates acute lung injury induced by bilateral lower limb ischemia-reperfusion in rats.

Hsu KY, Tsai PS, Lee JJ, Wang TY, Huang CJ.SourceDepartment of Anesthesiology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
The Journal of surgical research.2011 May 15;167(2):e255-62. Epub 2010 Apr 24.
PMID 20472255

Lee JJ, Liu CL, Tsai PS, Yang CL, Lao HC, Huang CJ.SourceDepartment of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Department of Pharmacology, Taipei Medical University, Taipei, Taiwan.
The Journal of surgical research.2011 May 15;167(2):e299-305. Epub 2009 Dec 22.
PMID 20338586

Japanese Journal

Platonin, a Cyanine Photosensitizing Dye, Inhibits Pyrogen Release and Results in Antipyresis

LEE Jie-Jen,HUANG Wu-Tein,SHAO Dong-Zi,LIAO Jyh-Fei,LIN Mao-Tsun
Journal of pharmacological sciences 93(3), 376-380, 2003-11-01
… When incubating the platonin with the LPS-human PBMC, both the levels of IL-1β, IL-6, or TNF-α in supernatant fluids and the pyrogenicity of supernatant fluids were significantly suppressed. … In addition, both the fever and the increased levels of either IL-1β, IL-6, or TNF-α in rabbit serum following an intravenous administration of LPS were significantly attenuated by pretreatment with an intravenous dose of platonin. …
NAID 130000073931

Platonin, a Photosensitizing Dye, Improves Circulatory Failure and Mortality in Rat Models of Endotoxemia

HSIAO George,LFE Ji-Jen,CHOU Duen-Suey,FONG Tsorng-Harn,SHEN Ming-Yi,LIN Chien-Huang,SHEU Joen-Rong
Biological & pharmaceutical bulletin 25(8), 995-999, 2002-08-01
… Platonin, a cyanine photosensitizing dye, is a potent macrophage-activating agent and an immunomodulator. … In this study, we compare the inhibitory effects of platonin with those of the three clinical drugs minocycline, clindamycin, and cyclosporin, on hypotension, tachycardia, and nitric oxide (NO) formation in a rat model of circulatory shock induced by Escherichia coli lipopolysaccharide (LPS). …
NAID 110003638862